Remebentin Remedica Treatment of pain caused by neuropathy and epilepsy (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Gabapentin

Ingredient

Composition information	Content
Gabapentin	100mg

Uses

indications

Remebentin 100 drugs are indicated in the following cases:

Remebentin is indicated for treatment of pain caused by neuropathy and epilepsy. The drug is also prescribed partially and partially accompanied by partial epilepsy in patients who have not achieved adequate control, or in non -tolerated people, standard epilepsy medications used alone or in combination.

For children 6 - 12 years old: Remebentin can be used for partial epilepsy and partial epilepsy accompanied by secondary all epilepsy in patients who have not achieved adequate control, or in non -tolerated people with standard epilepsy medications used alone or in combination. If the benefit is more than the risk, Remebentin must be started and monitored by a neurologist.

Pharmacology

Gabapentin is structured in terms of structure with gamma nerve transmission - Aminobutyric Acid (GABA) but its impact mechanism is different from many drugs interacting with GABA systems. The qualitative and function of the binding points with Gabapentin must still be clarified and the suitability of its various effects with anti -epileptic effects must be determined.

Angel activity has been shown in animal models that pain caused by inflammation and neuropathy. A randomly indicated study of a placebuarin was conducted in 247 children from 3 to 12 years old with difficult epilepsy. Participants receive 25 - 35 mg/kg/day or placebo as added. The effect has not been established in children under 6 years old.

Dynamic pharmacokinetics

Average Gabapentin concentration in plasma (CMAX) reached about 3 hours (TMAX) after taking single dose of Gabapentin regardless of the dose or dosage form. The average TMAX values after using multiple doses are about 1 hour shorter than the single dose. The value of cmax and auc increases when the dose increases; However, the increase is less than the dose increase rate. The deviation is very small to 600 mg for both parameters and therefore at least at 300 mg - 400 mg daily daily, it is usually the dose that has anti -epileptic effects. After repeated gabapentin doses, the concentration in a constant state is achieved within 1-2 days after starting to use many doses and maintained during the medication period.

The concentration data - Plasma gabapentin time is the same between capsules and solutions after single doses of 300 and 400 mg. Absolute bioavailability of oral doses of 300 mg of gabapentin is about 60%, at 300 mg and 400 mg, gabapentin does not change after many doses.

Based on the results of the bioavailing results are conducted with Gabapentin capsules, biology with 2 x 300 mg capsules have been circulated on the market with the same speed and level of absorption. Similar to biological equivalent 800 mg capsules with 2x 400 mg capsules circulating on the market with the same speed and level of absorption. The presence of food does not affect the bioavailability of gabapentin.

Gabapentin is not metabolized in humans and does not induce the oxidation enzymes of the liver's mixed function, the excretion of gabapentin after intravenous injection has also been carefully described by linear pharmacokinetics. Gabapentin's waste sale time (T1/2) is from 5 to 7 hours. Gabapentin elimination parameters, kidney clearance (CLCR) and T1/2 apparently independent of the dose. The renal removal is the only emissions of gabapentin. Because gabapentin is not metabolized in humans, the amount of drugs in urine is a biochemical indicator of gabapentin. After taking the single dose of 200 mg [C14] the radioactive activity of Gabapentin found about 80% and 20% in urine and feces respectively.

Because the kidney function (measured by creatinine clearance) decreases with age, oral gabapentin clearance, kidney clearance and the corresponding reduction rate constant.

Gabapentin pharmacokinetics are measured in a single dose study and a child research group from 1 to 13 years old. Gabapentin clearance is based on children over 4 years old in adults. Children from 2 - 4 years old seem to have higher clearance in weight. Under 2 years of age, gabapentin has changed strongly.

Before taking Remebentin Remedica Treatment of pain caused by neuropathy and epilepsy (5 blisters x 10 tablets)

How to use

Dosage

According to the instructions of the treating doctor.

Pain due to neuropathy

Adults over 18 years old:

To treat pain due to neuropathy, the dosage should be increased gradually until the maximum dose of 1800 mg daily with the starting dose is 300 mg daily.

Elderly:

Elderly patients may need to treat the dose due to impaired renal function by age.

epilepsy

Adults and children over 12 years:

For regular dose treatment is 900 - 1200 mg/day. Starting from 300 mg gradually increased to effective dose. Maximum of 2400 mg a day divided into several times.

Children from 6 to 12 years old:

The recommended dose is 25 - 35 mg/kg/day divided into several times (3 times a day).

Elderly:

Elderly patients may need to treat the dose due to impaired renal function by age.

Patients with kidney failure or dialysis patients:

Should use attack dose is 300 - 400 mg, then 200 - 300 mg after 4 hours of fertilizer.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Deliberately overdose or accidents with Gabapentin up to 49 g have no poisoning results, life threats, acute for patients. Overdose symptoms may include dizziness, but stuttering, drowsiness, slow and mild diarrhea, patients recover completely when treated support.

Although, gabapentin can be eliminated by dialysis, but not necessary. However, in patients with renal failure, dialysis can be appointed.

What to do when forgetting a dose? However, if it is almost time for the next dose, skip this dose and return to the normal medication schedule. Do not use double the dose. If you forget many doses, please consult a doctor.

Side Effects

When using Remebentin 100 you can experience unwanted effects (ADR).

Like all other drugs, Remebentin can cause unwanted effects. In the case of this medication to treat pain due to neuropathy, side effects are dizzy and drowsiness. Can be encountered: diarrhea, dry mouth, peripheral edema, weight gain, memory loss, loss, abnormal thinking, rash. Rarely: damage, weakness, back pain, constipation, flatulence, nausea, confusion, increased cold, dizziness, shortness of breath and laryngitis.

In the case of medication to treat epilepsy, the most common adverse effect is drowsiness and dizziness. In addition, other common side effects are loss, fatigue, vibration of the eyeball, trembling, but difficult to pronounce, dementia, weakness, abnormalities, joint pain, hemorrhage rash, shortness of breath, anxiety, weight gain, urinary tract infection and sore throat.

The more rare side effects are leukopenia, frustration, sore throat, and helplessness. More rare is urinating many times, pancreatitis, increased liver function tests, diverse roses and Stevens - Johnson syndrome.

Rarely confusion, depression, emotional, aggressive, abnormal thinking and mental/hallucinations, changing blood glucose in diabetics, muscle aches, headaches, nausea and/or vomiting.

In the case of children 3 - 12 years old, the most common side effects are easy to emotion, frustration, abnormal thinking and more rare is sleepiness, fatigue, weight, aggressive, dizzy, increased movement, nausea, vomiting, viral infection, bronchitis, respiratory infections.

may also be acute renal failure, allergic reactions, including urticaria, hair loss, angioior, chest tightening, hallucinations, movement disorders, muscle disorders, chest drums, platelets and tinnitus. Sudden remebentin stops can increase anxiety, insomnia, nausea, pain and sweat.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Remebentin 100 contraindications in the following cases:

Too hypersensitivity to Remebentin or any ingredient of the drug.

Should not be used for children under 6 years old.

Be cautious when using

If you do not tolerate some types of sugar, notify your doctor before taking this medication.

Although there is no evidence of epilepsy backwards to Remebentin, stopping sudden anti -epileptic drugs in epilepsy patients can cause seizures. Any decrease in the dose, stopping or anti -epileptic drugs must be done gradually for at least a week.

Remebentin is often not considered to have the effect of treating epilepsy without consciousness. Patients using Remebentin may suffer from personality and personality disorders.

Should be especially cautious for patients with a history of mental disorders and patients with dialysis.

The ability to drive and operate machinery

gabapentin affects the central nervous system and can cause drowsiness, dizziness or other relevant symptoms, although mild, but also affects the ability to drive and operate the machine. For this reason, avoid driving and operating the machine at least until establishing experience with drugs in each patient.

Pregnancy

Do not take drugs during pregnancy. Consult with the doctor when using any medicine.

breastfeeding period

gabapentin through breast milk so do not use medication for nursing women.

Interactive drug

many drugs interact with gabapentin and should not be used simultaneously. However, some drugs can be used simultaneously under special caution. In this case, your doctor may change the dose and apply other steps if needed.

It is important to notify your doctor what the medicine you are taking, especially the following drugs: antacids containing aluminum and magnesi, Morphin.

Other forms of interactions: Positive positive with protein in urine Testing - Metabolism - Elimination, n - multistix, SG8 embedded stick when Remebentin is used with other anticonvulsants.

Storage

Store at temperatures below 25 ° C. Avoid light and damp.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.