Remoclar 500 Remedica treats respiratory infections (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Clarithromycin

Ingredient

Composition information	Content
Clarithromycin	500mg

Uses

Indications

Remoclar 500 pills are indicated in the following cases:

Remoclar is indicated to treat infections caused by sensitive strains. Remoclar is also indicated to kill H. pylori in patients with peptic ulcer.

Pharmacokological study

Clarithromycin is the semi -synthetic substance of erythromycin A. Anti -bacteria by attaching to the ribosom 50s of sensitive bacteria and inhibiting protein synthesis. A strong antibiotic antibiotic against many G-- GR+ aerobic and anaerobic bacteria. The minimum inhibitory concentration (MICS) of Clarithromycin is generally 2 times lower than that of Erythromycin's microphone. Clarithromycin's 14-hydroxy metabolism also has antibacterial activity. The microphone of this type of metabolism is equivalent to or 2 times higher than the mother subtract to H. Influenzae (14-hydroxy metabolites have twice as strong as the mother).

On In vitro, Remeclar usually works on the following bacteria strains:

GR+: Staphylococcus aureus (methicillin sensitive); Streptococcus Pyogenes (Beta blood soluble streptococcus group A), Alpha-Hemolytic Streptococci (Viridans Group); Streptococcus (diplococcus) pneumoniae; Streptococcus Agalactiae; Listeria monocytogenes.

GR- bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella (Branhamella) Catrhalis, Neisseria Gonorrhoeae; Legionella Pneumophila, Bordetella Pertussis, Helicobacter Pylori; Campylobacter Jejuni.

Mycoplasma: Mycoplasma pneumoniae; Ureaplasma Urealyticum.

Other strains: Chlamydia trachomatis; Mycobacterium avium; Mycobacterium leprae.

Anaerobic bacteria: Bacteroides Fragilis sensitive to macrolide; Clostridium perfringens; Peptococcus species; Peptostreptococcus species; Propionibacterium acnes.

Clarithromycin has bactericidal effects on some bacterial strains such as: Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Moraxella (Branhamella) CatVrhalis, Neisseria Gonorrhoeea, H. Pylorae, H. Pylorae and H. Pylorie Campylobacter spp. The anti -pylori effect of clarithromycin in the neutral pH environment is greater than the acid pH environment.

pharmacokinetic

Clarithromycin is absorbed quickly and well through the digestive tract after drinking. Metabolic agent 14-hydroxyclarithromycin, after metabolism, still acts on bacteria. The time to use Remeclar does not depend on the meal because the food does not affect the bioavailability of the remeclar tablet. Food slows down the initial absorption and metabolism formed into a 14-hydroxy metabolic form of clarithromycin. The pharmacokinetics of Clarithromycin are not linear; Stable state achieved within 2 days of medication. With a dose of 250 mg 2 times/day, 15-20% of the drug is in the form of the urine. With a dose of 250 mg x 2 times/day daily use, the amount of drug excreted in urine is larger (about 36%). 14 -Hydroxyclarithromycin is the main form of metabolism found in urine and accounts for about 10-15% of the dose. Most of the remaining parts are eliminated through feces, mainly through bile. 5 - 10% of original pure drugs were found in the feces.

When using Clarithromycin 250 mg 3 times/day, the clarithromycin concentration in plasma increases corresponding to the dose of 250 mg x 2 times/day.

The remoclar concentration is achieved in a few times higher than the concentration of drugs in the blood. Increased concentration is also seen in tonsils and lung tissue. At the treatment dose, 80% Clarithromycin binds to plasma proteins.

Remeclar penetrates into the stomach mucous membrane. Clarithromycin concentration in stomach mucous membranes and in the stomach tissue when used in combination with clarithromycin with omeprazole is higher when using only clarithromycin.

Before taking Remoclar 500 Remedica treats respiratory infections (2 blisters x 7 tablets)

How to use

can use Remoclar medicine with or not with food.

Treatment period

To completely cure the infection, the time to use the drug should follow the doctor's instructions even though you may feel better after a few days of taking the drug.

If the drug is stopped earlier than prescribing symptoms may reappear.

The effect of Clarithromycin will be better if maintaining the concentration of constant drug in the blood, so the distance between the drug use should be fixed. For example, if the drug is taken 2 doses in 24 hours, the distance between the doses must be 12 hours. Please consult a doctor or pharmacist if the medication time affects sleep or the activities of your day or you want to advise to arrange the medication schedule.

Dosage

According to the doctor's instructions.

Respiratory infections, skin infections and soft tissue

Adults

250 mg x 2 times/day x 7 days, can increase the dose to 500 mg/time x 2 times/day and can be used up to 14 days in case of severe infection.

Children greater than 12 years old

Dosage and usage like adults.

To kill H. pylori in patients with peptic ulcer (for adults):

The course consists of 3 drugs (7 - 14 days): 500 mg Clarithromycin/time x 2 times/day and lansoprazole 30 mg/time x 2 times/day should be used with amoxycillin 1000 mg/time x 2 times/day for 7 to 14 days. 30 mg/time x 2 times/day should be used with metronidazole 400 mg/time x 2 times/day for 7 days. Clarithromycin x 2 times/day should be used with amoxycillin 1000 mg 2 times/day and omeprazole 20 mg/day for 10 days. Remoclar should be used with omeprazole oral 40 mg/day for 28 days.

Elderly people

Like young adults.

kidney failure

250 mg x 1 time/day or 250 mg x 2 times/day in case of severe infections.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

Symptoms of overdose: Symptoms on the gastrointestinal tract and rarely change mental state, paranoia behavior, hypotension, hypoxemia. Overdose reactions should be treated with stomach and supportive measures.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? If the time to remember is near the time of taking the next dose, not using the forgotten dose but taking the drug in accordance with the old schedule. Do not drink double the dose. Advice your doctor if you forget to take more than 1 dose because you may have to start a new course.

Side Effects

When using Remeclar 500 , you may experience unwanted effects (ADR).

Unwanted unwanted effects are: Nausea, vomiting, indigestion, diarrhea, urticaria and other allergic reactions, deaf when using large doses and recovery when stopping the use of drugs, jaundice, hepatitis, headache, sensory disorders of taste, changing color of teeth and tongue, stomach inflammation, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, dizziness, irritation mixed, mental disorders, hypoglycemia, syndrome, Stevens-Johnson tachycardia.

Instructions on how to handle ADR

Stop using the drug. With minor adverse reactions, usually just stop the drug. In case of severe sensitivity or allergic reactions, supportive treatment (airy keeping and using epinephrin, oxygen breathing, antihistamine, corticoid ...).

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Remoclar 500 contraindications in the following cases:

Patients with hypersensitivity to macrolide antibiotics. There has been a report that shows that the concentration of cisapride, pimozide and terfenadine increases in patients when using the same drugs on the same clarithromycin, which can cause QT interval and arrhythmia, including ventricular tachycardia, ventricular vibration and Torsade de pointes. The same effects have been seen when using Astemizole in combination with other macrolides.

Precautions when used

The ability to drive and operate machinery

Be careful because Clarithomycin can cause dizziness.

Pregnancy

should not use clarithromycin for patients during pregnancy. Refer to the advice of a doctor or pharmacist before using any drug.

Breastfeeding period

should be cautious while breastfeeding because it is not known whether the drug is excreted in breast milk. Refer to the advice of a doctor or pharmacist before using any drug.

Drug interaction

Some drugs interact with Clarithromycin. Do not use simultaneously with interactive drugs with clarithromycin.

However, some medications interact with Clarithromycin can still be used simultaneously but should be especially careful. In this case, your doctor may change the dose or some other carefully if needed.

It is important that you notify your doctor or pharmacist if you are taking other drugs, especially the following drugs: Theophylline, carbamazepine, Midazolam, Triazolam, Alprazolam, Sildenafil, Quinidine, Tacrolimus, Warfarin, Digoxin, Ergotamine or Dynhotamine, Phenytoin, Phenytoin, Phenytin, PhenytoTo, PhenytoTo, Phenytin, Phenytin, Phenytoin, Phenytine, Phenytine, PhenytoTo, Phenytine, Phenytine, PhenytoTo Disopyramide, Symvastatin or Lovastatin, Cyclosporine, Zidovudine, Rifabutin, Ritonavir, Ranitidine, Colchicine, Omeprazole, Maalox.

Storage

Store at temperatures below 25 ° C. Avoid moisture and light.

To be out of reach of children.

Expiry date: 36 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

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