Resilo 25 Dr.Reddy's medicine for high blood pressure (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	25mg

Uses

Indications

Resilo drug is indicated in the following case:

High blood pressure treatment, single or coordinated with other anti -blood pressure.

Pharmacokological

Losartan selectively connects and competes with Angiotensin II receptors at the secondary tube 1, thus preventing the physiological effects caused by Angiotensin II.

Losartan and its main metabolites inhibit vascular shrinkage and inhibit the excretion of angiotol's aldosterol secretion by inhibiting Angiotensin II's cohesion selection with AT receptors, in many different types of tissue.

The metabolites are mainly Losartan - E3147, which has a significant lowering effect of prolonged low voltage during 24 hours after a single dose of the day.

pharmacokinetics

After drinking, Losartan is absorbed well and undergo an important metabolic process. Born to learn all over 33% and about 14% of Losartan's oral doses are transformed into active metabolites. The average peak concentration of Losartan in plasma is reached for about 1 hour and of its active metabolites is 3-4 hours.

Food slows down the absorption and reduces the maximum concentration of Losartan, but only has a slight effect on the area under the curve of Losartan and the main metabolite (10%reduction).

Losartan and metabolites are strongly connected to plasma proteins (mainly albumin). About 4% of Losartan's oral dose is excreted in the urine in the form of constant and 6% excreted in the urine in the form of active metabolites. Part of the Losartan and its active metabolites are excreted through the bile. After the dose, about 35% found in urine and 60% in feces.

Before taking Resilo 25 Dr.Reddy's medicine for high blood pressure (2 blisters x 10 tablets)

How to use

Losartan can take or taken once or divided into 2 times on 25 - 100 mg. Losartan can be taken at the same time as food or not food.

Dosage

The usual dose of Losartan is 50 mg/time/day.

The starting dose of 25 mg can be used for patients being treated with diuretics or patients with a history of liver failure.

Losartan should be used simultaneously with other antihypertensive drugs if the blood pressure level is not controlled by a single therapy mode.

Older patients:

For patients ≤ 75 years old: No dose adjustment. For patients with medium to severe kidney failure or patients who are hemolysis, should start at a dose of 25 mg.

For example, patients being treated with diuretics are very high, so start at a dose of 25 mg.

Patients with liver failure:

Should reduce the dose in these patients.

Children:

The effectiveness of Losartan's efficiency in pediatric patients has not been set up.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Slow heart rate may also occur due to sympathetic stimulation. If the hypotension has symptoms, it is recommended to be treated with supportive measures. Losartan and its active metabolites cannot be fertilized.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Resilo, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, diarrhea, digestive disorders.

muscle, bone, joint: muscle contraction, musculoskeletal pain.

nerve: dizziness, insomnia.

Respiratory: cough, stuffy nose.

Systemic: Fengshedling (including swelling of the face, lips and/or tongue).

Unknown frequency ADR:

Metabolism: hyperkalemia, slightly increased bun or serum creatinine, slightly increased liver enzyme or serum bolirubin.

Hematology: Mitigating haemoglobin and haematocrit.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Resilo drugs contraindicated in the following cases:

Pregnant women.

Patients with hypersensitivity to any ingredients in the drug.

Precautions when used

In the state of intravascular volume exhaustion (for example, patients being treated with diuretic drugs in very high doses), hypotension may occur. This condition must be adjusted before starting treatment with Losartan or the starting dose must be reduced.

Kidney artery stenosis: Drugs that act on the Renin - Angiotensin - Aldosterone system may increase blood urea and creatinine in serum in patients with narrowed kidney stenosis on both sides or artery stenosis in patients with a unique kidney, which is thought that Angiotesin II receptor inhibitors can also cause the above -mentioned effects.

Resilo should not be used with diuretics that cause potassium loss.

Should reduce the dose for patients with liver failure because there is an increase in Losartan concentration in plasma.

Losartan treatment for patients with congestive heart failure is associated with urinary disorders, increased blood urea and rarely causes kidney failure and/or death.

The ability to drive and operate machinery

There is no research on the effects of drugs on driving ability and using machines.

However, when driving or operating machines, it should be noted that sometimes dizziness or drowsiness can occur when taking antihypertensive drugs, especially when starting treatment or when increasing the dose.

Pregnancy

must not use Losartan for pregnant women. If you find pregnancy, you must stop taking the medication immediately.

When using drugs for pregnant women in the last 6 months of pregnancy, the drug has a direct impact on the Renin - Angiotensin system that may hurt, even the fetal death is developing. When detecting pregnancy, it must immediately stop taking Losartan as soon as possible. For children who are more likely to have been exposed to angiotensin receptor inhibitors when they are still in the uterus, careful monitoring of hypotension, hyperactical hyperkalemia (patients need to be infused or fertilizer to regulate blood pressure and/or disorders of renal function).

Breastfeeding period

Because people still do not know whether the drug is excreted through breast milk or not, so it is necessary to stop breastfeeding or stop using Losartan after considering the benefits of the mother's use and the harm if there is the drug caused to the child.

Drug interaction

Pharmacokinetics, Losartan does not have significant drug interactions for drugs such as Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine and Phenobarbital. Interactions with strong Cytochrome P450 3A4 (ketoconazole, troleandomycin) or P450 2C9 (sulfaphenazole) significantly inhibit the formation of active and almost completely inhibited metabolites when combined with sulfaphenazole and ketoconazole. The pharmacodynamics of the use of these inhibitors simultaneously with Losartan have not been checked.

Storage

Store in a cool dry place, under 30 ° C, avoid light.

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