Richstatin medicine 10mg Getz lower blood lipid (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Rosuvastatin

Ingredient

Composition information	Content
Rosuvastatin	10mg

Uses

Indications

Richstatin medicine 10mg is indicated in the following cases:

Treatment in coordination with a diet to reduce total cholesterol levels, LDL-Cholesterol, Apolipoprotein B, Triglycerides and HDL-cholesterol growth in primary hypercholesterol patients (family and non-family-tempered heterosexuals), combined blood lipid disorders (Lipoprotein Lipoprotein IIA and IIBROIN Fredrickson).

coordinates with diets in the treatment of increased plasma triglycerides (hyperglycerary disease of type IV blood according to Fredrickson classification).

Reduces total cholesterol, LDL-Cholesterol and Apolipoprotein B in patients with homosexual cholesterol, to support diets and non-drug lipid reducing treatments or other methods of lipid reduction treatment, or when these treatments are not appropriate or inadequate. The learning force

Rosuvastatin is a selective and competitive inhibitor HMG-Coa Reductase, is the catalyst of the conversion process 3 -Hydroxy-3-methylglutarart coenzyme A into Meovalonate, a precursor of cholesterol. The main effect of rosuvastatin is the liver, the target organs reduce cholesterol.

Studies on Vivo and In Vitro show that RosuVastatin works in two ways: First, increase the number of LDL receptors on the cell surface in the liver, thus increasing LDL absorption and catabolism. Secondly, the drug inhibits VLDL synthesis in the liver, thus reducing the number of VLDL and LDL components.

pharmacokinetic

absorption

Rosuvastatin's peak plasma concentration is about 5 hours after drinking. Absolute bioavailability is about 20%. Both CMAX concentration and area under the AUC curve increasing in the dose. Using rosuvastatin with food reduces the absorption rate of about 20% in CMAX, but does not affect the level of absorption according to AUC.

Distribution

Rosuvastatin widely distributed in the liver is the main place for cholesterol and LDL-C clearance. The distribution of rosuvastatin is about 134L. About 88% of rosuvastatin associated with plasma proteins, mainly albumin. This cohesion may be reversed and regardless of plasma concentrations.

Metabolism

Rosuvastatin is less metabolized (about 10%). The main metabolic substance is N -De -Methyl (which is about 50% weaker than RosuVastatin) - made up of Cytochrome P450 2C9 - and lactone metabolites (without clinical activity). Rosuvastatin accounts for more than 90% of HMG-COA Reductase inhibitors in circulation.

Elimination

After drinking, about 90% of the dose of rosuvastatin and metabolites are deducted through feces and about 5% are secreted into urine in the form of constant. Selling time is about 19 hours. Sell waste time does not increase when using higher doses.

Before taking Richstatin medicine 10mg Getz lower blood lipid (1 blister x 10 tablets)

How to use

Take oral use.

Dosage

recommendation to start treatment with the lowest dose that the drug works, then if necessary, can adjust the dose according to the needs and response of each person by increasing the dose of each span of no less than 04 weeks and monitoring the harmful reactions of the drug, especially harmful reactions to the muscle system.

Related between rosuvastatin's dose and muscle elimination should be noted: All patients start at 10mg doses/day and only increase to 20mg if necessary after 4 weeks. Closely monitoring for 40mg dose.

According to the pharmacokinetic research in the US in Asians, the ability to absorb Rosuvastatin in Asians is twice as increased compared to white people, so it should be considered the starting dose of 5mg for Asians.

Patients need to follow a diet that reduces cholesterol as prescribed before taking richstatin (rosuvastatin) and continues this diet during the use of drugs, Richstatin (Rosuvastatin) is used for single doses at any time of the day, along with or not with food.

Hypermathed blood cholesterol (heterozygo is family and unmarried) and combined blood lipid disorders (type IIA and IIB according to Fredrickson classification)

Rosuvastatin dose from 5 - 40mg, taken once a day, depending on the patient's therapeutic and response purposes. The normal starting dose recommends for Richstatin (Rosuvastatin) is 10mg, 1 time/day. The starting dose of 5mg/time/day is applied to patients who do not have a positive LDL-cholesterol reduction requirement or patients with muscle disease. For patients with significant hypercholesterol hyperplasia (LDL-Cholesterol content> 190mg/dL) and requires positive lipid reduction, may consider the starting dose of 20mg. After the starting dose or simultaneously with quantitative richstatin (rosuvastatin), test blood lipid concentration should be tested for 2-4 weeks to adjust the appropriate dose. The dose of 40mg is only for patients who do not achieve the goal of reducing LDL-cholesterol as expected when using a dose of 20mg/day.

Increased plasma triglyceride levels (hyperglyceride disease/ type IV Fredrickson)

Rosuvastatin dose is used from 5 - 40mg, taken 1 time/ day. The normal starting dose is 10mg/day, adjusted based on blood lipid concentration, daily monitoring for 2-4 weeks until the desired level is reached.

Hypermathed blood cholesterol is family -owned.

The recommended starting dose for Richstatin (Rosuvastatin) is 20mg, 1 time/day in patients with hypertension hyperplasia. The maximum dose of the day is 40mg.

Richstatin (Rosuvastatin) is used in these patients to support other treatments that reduce blood lipids.

Can refer to the following instructions to set treatment goals:

ADDITIONAL CONTROLLING BY NCEP (National Cholesterol Education Program - USA)

Risk factors

LDL target (mg/dl)

Drugs CHD*or the risk equivalent to CHD (risk in 10 years> 20%)

≥ 100 ≥ 130 (100 - 129 is not required to use drugs **) ≥ 130 ≥ 130 and risk 10 years 10-20% 160 ≥ 160

≥ 190 (169 - 189 is not required to use LDL reduction pills)

** Some authors recommend using LDL medications in case LDL-cholesterol levels

*** Most patients with 0 -1 risk factors are at 10 years at risk

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Richstatin 10mg , you may experience unwanted effects (ADR).

Rosuvastatin is often well tolerated. The side effects are usually light and transient.

Popular

headache, dizziness, constipation , nausea, abdominal pain, muscle aches and weakness.

Less popular

Itching, erythema, urticaria.

Rarely occurs hypersensitive reactions including muscle disease, muscle urinary, arthritis, and hyperplayer liver transaminase.

Very rare

jaundice , hepatitis, polygoma.

Abnormalities in testing

proteinuria occurs in patients treated with rosuvastatin. This happens more often in patients with high doses of Rosuvastatin 40mg. Other abnormalities reported include increased creatinine phosphokinase, hygiene of transaminase associated with dosage, hyperglycemia, glutamyl transpeptidase, alkalin phosphatase, bilirubin and thyroid function abnormalities.

In addition, there are the following side effects:

Cognitive decline (such as memory loss, confusion ...).

Hyperglycemia .

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Richstatin 10mg drug contraindicated in the following cases:

Rosuvastatin is contraindicated in patients with hypersensitivity to any ingredients of the drug.

Patients with liver disease, including increased plasma transaminase for unknown reasons and cases of increased transaminase more than 3 times the above limit.

Pregnant and lactating women, women who have suspected pregnancy and do not use appropriate contraception before.

Patients with severe renal impairment (Creatinine clearance

Patients with muscle disease.

Patients are using cyclosporin.

High doses of 40mg Rosuvastatin contraindicated in patients with risk factors for muscle disease/muscle disease include:

Average renal failure (Creatinine clearance

Alcohol abuse.

Precautions when used

Caution with statin medications: It is necessary to consider when taking drugs in the statin group for patients with risk factors leading to muscle damage. The statin is at risk of harmful reactions to the muscle system such as muscle atrophy, muscleitis, especially for patients over 65 years old, patients with untreated thyroid diseases, patients with kidney disease. Need to closely monitor the harmful reactions during the use of the drug.

Patients should immediately report to the doctor to treat signs or symptoms of muscle pain, fatigue, fever, dark urine, nausea or vomiting during the use of the drug.

Before starting treatment with rosuvastatin, patients need to make efforts to control hyperchemical cholesterol with diet, exercise and weight loss appropriate in obese patients, and treat other basic disorders.

At the beginning of the treatment therapy with statin or transferred from other statin therapy to using rosuvastatin, the starting dose of rosuvastatin must be adjusted appropriately and depending on the goals of treatment in each patient.

HMG-CAA Reductase inhibitors, as well as other hypoglycemic therapies, are related to liver function abnormalities.

Recommended the liver enzyme test before starting statin treatment and in case of clinical indications for testing later.

Consider monitoring Creatin Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic muscle disease, a history of muscle disease due to statin or fibrat before, a history of liver disease or drinking lots of alcohol, elderly patients (> 70 years old) with risk factors for muscle pattern, special patients with drug interactions. In these cases, the benefits/risks should be considered and monitor patients on the clinic when treated with statin. If the test results CK> 5 times the upper limit of the normal level, do not start treating with statin.

During statin treatment, patients need to notify when there are muscle manifestations such as muscle pain, stiffness, muscle weakness ... When there are these manifestations, patients need to test CK to take appropriate interventions.

Used in children: Effective and safe when using drugs in children has not been established.

The ability to drive and operate machinery

Rosuvastatin can cause dizziness during treatment. Therefore, it is necessary to be cautious when driving and operating machinery.

Pregnancy

Rosuvastatin is contraindicated in pregnant women. Women are at reproductive age should use appropriate contraception. Because cholesterol and other products of the cholesterol biosynthesis are necessary for the development of the fetus, the potential risk from HMG-Coa Coenzyme A inhibitors will be higher than the benefits of treatment during pregnancy.

Breastfeeding period

Rosuvastatin is contraindicated in pregnant and lactating women. It is not known whether rosuvastatin is secreted into breast milk or not, need to be cautious when taking medicine in nursing women.

Drug interaction

Increased risk of muscle lesions when using statin simultaneously with the following drugs:

gemfibrozil.

Statin lipid medications with HIV and hepatitis C (HCV): The simultaneous use of statin lipid medications with HIV and hepatitis C (HCV) can increase the risk of muscle damage, the most serious pattern, kidney damage leading to kidney failure and may cause death.

recommendations on drug interactions between statins and protease inhibitors of HIV and HCV:

Coumarin: In patients using simultaneously anticoagulant drugs Coumarin and Rosuvastatin, Inr must be determined before using rosuvastatin and regularly in the beginning to ensure that the Inr change is negligible.

Antacislets: Sharing antacids (Aluminum and Magnesi Hydroxyd) with rosuvastatin (dose of 40mg) reducing plasma concentrations of rosuvastatin about 50%. Equity should be taken at least 2 hours after drinking rosuvastatin.

Cyclosporin: combining cyclosporin and rosuvastatin, resulting in an increase in cmax concentration and an area under the AUC curve of Rosuvastatin is 11 and 7 times compared to healthy people. Contraindicated to share cyclosporin and rosuvastatin.

Gemfibrozil: Gemfibrozil combination (600mg, 2 times/day) and single dose rosuvastatin leads to an increase in cmax concentration and area under the AUC curve of Rosuvastatin 2.2 and 1.9 times.

Oral contraceptives: Sharing oral contraceptives (Ethinyl estradiol and Norgestrel) and Rosuvastatin increases the plasma concentrations of Ethinyl estradiol and Norgestrel to 26% and 34% respectively.

erythromycin: Sharing Erythromycin and Rosuvastatin reduces 20% of the area under the curve and 30% of the plasma concentration of CMAX plasma of Rosuvastatin.

Storage

At temperatures below 30 ° C, avoiding light and moisture.

Expiry date: 36 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

to be out of reach of children.

Read the instructions carefully before use.

If you need more information, please consult your doctor.

This drug is only used as prescribed by a physician.

Manufacturer: Getz Pharma Company (PVT) Ltd.

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