Rifampicin 300mg Mekophar medicine for tuberculosis, leprosy (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Rifampicin

Ingredient

Composition informationContent
Rifampicin

Uses

Indications

Rifampicin 300 mg drug is indicated in the following cases:

  • Treatment of tuberculosis, leprosy and severe infections caused by gram (+) and (-) bacteria.

    Rifampicin is a semi -synthetic antibiotic belonging to the Rifamycin family, with bactericidal activity against mycobacterium strains and gram -positive bacteria.

    Rifampicin also against Gram -negative bacteria at higher concentrations.

    Rifampicin's action mechanism is to prevent bacterial biosynthesis bacteria by inhibiting RNA polymerase through drug -enzyme sustainability.

    pharmacokinetic pharmacokinetics

    Rifampicin is quickly absorbed through the gastrointestinal tract, slow food and reducing drug absorption.

    Rifampicin is widely distributed into tissues and fluid fluids, metabolism in the liver and eliminated through bile, feces and urine.

    • Before taking Rifampicin 300mg Mekophar medicine for tuberculosis, leprosy (10 blisters x 10 tablets)

    How to use

    Rifampicin 300 mg is used orally. Should drink when hungry with 1 cup of full water (1 hour before eating or 2 hours after eating).

    Dosage

    Tuberculosis

    1 time, adults and children: 10 mg/kg body weight, maximum 600 mg, used in combination with other anti -tuberculosis drugs (Inh, Streptomycin, Ethambutol ...).

    leprosy

    1 -time month.

  • Children 0 - 5 years old: 150 - 300 mg.
  • Children 6 - 14 years old: 300 - 450 mg.

    Do Heamophilus Influenzae

    1 time, use for 4 consecutive days.

  • Children
  • Children ≥ 1 month of age: 20 mg/kg.

    2 times a day, take 2 consecutive days.

  • Children
  • Children ≥ 1 month of age: 10 mg/kg.
  • Children
  • Children ≥ 1 month and adults: 20 - 30 mg/kg/day, divided into 2 times.
  • 900 mg/day/1 time in combination with Doxycycline.

    • Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when using overdose?

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Rifampicin 300 mg, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • Urine, feces and tears are red orange.
  • Mild digestive disorders.
  • Body: fatigue.
  • Hematology: thrombocytopenia, leukopenia, hemolytic anemia.

    • Instructions on how to handle ADR

    Notify the doctor with unwanted effects when using the drug.

    Systemic immune response, such as cold, fever, rare during continuous treatment.

    In case of a banner or hemorrhage or suddenly reducing kidney function, rifampicin must be stopped immediately (common in interrupted treatment).

    Reduce kidney function before using rifampicin does not hinder treatment, but it is necessary to reduce the dose (apart drinks).

    For elderly patients, alcoholic or liver diseases will increase the risk of toxicity to the liver, especially when rifampicin combined with isoniazid.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Rifampicin 300 mg is contraindicated in the following cases:

  • Hypersensitivity to Rifamycin antibiotics.
  • Porphyrin metabolic disorders.

    Precautions when using

    during treatment time, blood formula and liver function must be conducted.

    The ability to drive and operate machinery

    Be careful when used for driving objects and operating machinery.

    Pregnancy

    Rifampicin for pregnant women in the last 3 months may bleed due to prothrombin reduction. Therefore, Rifampicin should only be used when considering the benefits with possible risks to the fetus.

    Breastfeeding period

    rifampicin eliminated through breast milk, but almost no risk to the baby.

    Medicinal interaction

    Rifampicin in combination with Isoniazid (Inh) and Pyrazinamid will increase the toxicity of the liver.

    Rifampicin causes Cytochrome P450 enzyme induction, increasing the metabolism of drugs: contraceptive drugs, anticoagulant drugs, digitoxin, ketoconazole, erythromycin, clarithromycin, diazepam, beta blockers, calcium blockers ... The above drugs in combination with rifampicin need to adjust the dose.

    Some drugs when used with rifampicin will reduce Rifampicin absorption: acid resistance, bentonite, clofazimine, ... overcome by separate drinks 8 - 12 hours apart.

    To avoid interactions between drugs, notify the doctor or pharmacist about the drugs being used.

    • Storage

    Store in a dry place, avoid light, temperature below 30 ° C.

    Other drugs

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    count views

    Popular Keywords