Risdontab 2 Danapha Treatment of acute and chronic schizophrenia (5 blisters x 10 tablets)

Dosage form Box of 5 blisters x 10 tablets
Specifications Risperidone

Ingredient

Composition information	Content
Risperidone	2mg

Uses

indications

Risdontab 2 5x10 Danapha is indicated in the following cases:

Acute and chronic schizophrenia treatment, which highlights positive symptoms (such as hallucinations, disorders in thought, hostile attitude, suspicion) and/or negative symptoms (such as naive, crouched, quiet).

Pharmacokinus

Risperidon is a benzisoxazol anti -psychotic drug, which has a selective antagonistic effect with tube 2 (5HT) serotonin receptor (5ht) and tube 2 (D) dopamine receptor. Risperidon is also associated with Adrenergic Alpha receptor and with H1 histamine receptors. There are very few anti -cholinergic side effects.

A balanced effect between antagonism with 5HTC and D receptor has a good effect against positive symptoms (illusion, abnormal thoughts, hostility, speculation reactions (paranoia) and anti -negative symptoms (psychotic discrete, losing sympathy, behavioral disorders, loss of speech) in the psychiatric mental effect. God, therefore, there may be drug interactions with painkillers and sedatives.

pharmacokinetics

Risperidon is well absorbed by oral. Food does not affect the speed or level of absorption. Risperidon is metabolized in the liver thanks to Cytochrom P450 2D6 into a major conversion, active as 9 - hydroxyrisperidon. This substance is valid equal to Risperidon in terms of activity associated with receptors and half -life is 20 ± 3 hours. After taking Risperidon, the plasma peak concentration is reached within 1 hour. Oral bioavailability is 66 ± 28% in strong and higher metabolic people in people with weak metabolism.

The level of plasma protein is 89% for Risperidon and 77% for active metabolites. The distribution of Risperidon is 1 - 2 liters/kg. In people with strong metabolism, the half -life of Risperidon is 3.2 ± 0.8 hours, the elimination through the urine is 3 ± 2% and the clearance is 5.5 ± 2 ml/min/kg. The metabolites are active, 9 - Hydroxyrisperidon has half a lifetime of 20 ± 3 hours.

Before taking Risdontab 2 Danapha Treatment of acute and chronic schizophrenia (5 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Following the instructions of the physician, or the average dose:

Adults

Often used initial dose 1 mg x 2 times/day. The dose may be increased with an increase of 1 mg x 2 times/day on Monday and Tuesday, until the dose of 3 mg x 2 times/day. If hypotension occurs during the dose, the dose must be reduced. The next dose adjustment is usually done at a distance of at least 7 days, with an increase or decrease of 1 mg, twice a day.

The maximum effect of Risperidon is achieved at a dose of 4 - 6 mg daily. The daily dose higher than 6 mg does not work better but also causes worse side effects, including foreign symptoms. Do not take the dose exceeding 6 mg daily.

Elderly or patients with kidney failure and liver failure

Because the elimination of Risperidon may be reduced and the risk of side effects increases in kidney failure and in the elderly, it is necessary to start treatment at a dose of 0.5 mg x 2 times/day and increase as needed, with an increase of 0.5 mg x 2 times/day; Increasing the overdose of 1.5 mg x 2 times/day must be done at a distance of at least 7 days. It is also necessary to reduce the dose in people with hepatic impairment because of the risk of increasing the amount of free risperidon in these patients.

Children

Not determined safety and effectiveness when used for children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Risdontab 2 5x10 Danapha, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: dizziness, increase in irritation, anxiety, chicken sleep, pagoda symptoms, headaches, Parkinson's syndrome.

digestive: constipation, nausea, vomiting, indigestion, abdominal pain, anorexia, increased salivation, toothache.

Respiratory: rhinitis, cough, sinusitis, sore throat, shortness of breath.

Skin: ban, dry skin, increase sebum secretion.

Neurological - muscle - bone - joints: joint pain.

Cardiovascular: tachycardia, hypotension with vertical posture.

Eyes: blurred vision.

Other: back pain, chest pain, fever, fatigue, upper respiratory infection, genital dysplasia.

Rare, ADR

Central nervousness: decreased concentration, depression, indifferent, reaction to increase tone, refreshment, sexual increase, memory loss, hard -to -speak, dizziness, stunning state, paresthesia, confusion.

digestive: flatulence, diarrhea, increased appetite, stomatitis, black stool, difficulty swallowing, hemorrhoids, gastritis.

Respiratory: rapid breathing, bronchospasm, pneumonia, hissing.

skin: increase or decrease sweat, acne, hair loss.

Cardiovascular: Hypertension, lower blood pressure, edema, atrial block, myocardial infarction.

Eye: regulating disorders, dry eyes.

Endocrine and metabolism: Reduce sodium - blood, increase or lose weight, increase creatin phosphokinase, thirst, diabetes, non -periodic milk secretion, loss of menstruation, menstrual pain, big breasts.

Urinary - genital: bedwetting, hematuria, difficulty, female breast pain, mid -menstrual bleeding, vaginal bleeding.

Hematology: Nosebleeds, hemorrhage, anemia.

Other: Cold, discomfort, symptoms like influenza.

Notify the doctor with unwanted effects when using the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Risdontab 2 5x10 Danapha contraindicated in the following cases:

Patients with overdose of Barbiturat, opium or alcoholic preparations.

Hypersensitivity to the ingredients of the drug.

Caution when using

can minimize the risk of lowering and fainting blood pressure during treatment with risperidon by limiting the initial bureaucracy at 1 mg x 2 times/day for normal adults and 0.5 mg x 2 times/day for elderly people or depression, people with impaired renal or liver function and people are at risk of lowering blood pressure.

In people with cardiovascular disease (severe arteriosclerosis, heart failure, conduction disorders), cerebrovascular disease or states that are prone to hypotension (dehydration, reduce blood flow, anti -hypertension therapy at the same time) and in people with a history of epilepsy, muscle spasm or Parkinson syndrome, it is necessary to use lower doses and start treatment at low doses.

Because Risperidon can disturb the ability to judge, think and move, patients should not drive or operate machines until sure that Risperidon does not have the above unwanted effect.

The ability to drive and operate machinery

No report.

Pregnancy

Do not use Risperidon for pregnant women.

The period of breastfeeding

is not sure whether the Risperidon is excreted in breast milk, so the person who is using Risperidon should not breastfeed.

Drug interaction

quinidine may increase the effect of the atrial - ventricular effect of Risperidon. Risperidon may increase the hypotension of anti -hypertension drugs. Risperidon may be opposed to the effect of levodopa and dopamine agreement. Long -term use of carbamazepin along with risperidon can increase the effect of risperidon. Due to the main effects on the central nervous system of Risperidon, risperidon doses must be used lower when combined with other medications on other central nervous systems and alcohol. In all these cases, the dosage needs to be adjusted.

Storage

Leave the medicine in a dry place, avoid light, temperature 15 ° C-25 ° C.

Expiry date: 36 months from the date of manufacture. Do not use overdue drugs stated on the packaging.

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