Risperstad 2 Stella medicine for acute and chronic mental disorder (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Risperidone

Ingredient

Composition information	Content
Risperidone	2mg

Uses

indications

Risperstad 2 drug is indicated in the following cases:

Treatment of schizophrenia and other mental disorders. Resistance on dopamine type 2 (d2) and serotonin type 2 (5ht2). The antagonistic effect at other receptors D2 and 5HT2 can explain some other effects of Risperidon.

Risperidon is a selective antagonist Monoaminergic with high affinity for Type Serotonin 2 (5HT2) and Dopamine Typ 2 (D2), A1 and A2 Adrenergic, and H2 Histaminergic. Risperidon works as a countervailing for other receptors but at lower validity, Risperidon has a medium -sighted affinity with 5HT1C, 5HT1D and 5HT1A Sarotonin receptors, 5HT1D and 5HT1A, weak affinity with Dopamin D1 receptor and Haloperidol sensitive site, no affinity for Cholinergic Musolgic Muscarinic or B1 and B1 and B1 and B1 and B1 and B1 and B1 and B1 Adrenergic.

Pharmacokinetics

absorption

Risperidon is well absorbed. Absolute bioavailability of about 70% (CV = 25%). After drinking, the average peak concentration of Risperidon is achieved after about 1 hour. Food does not affect the ratio as well as the absorption level of Risperidon.

Distribution

Risperidon is quickly distributed. The integral distribution is from 1 - 2 l/kg. In plasma, Risperidon binds albumin and alpha acid - glycoprotein. Risperidon binds to plasma proteins about 90%, and its main metabolites 9 - hydroxyrisperidon is about 77%.

Metabolism

Risperidon is metabolized mainly in the liver. The main metabolic path of risperidon is hydroxylated into 9 - hydroxyrisperidon by enamel CYP2D6. The secondary metabolic path is through the process N - Dealylation. The main metabolites are 9 - hydroxyrisperidon has the same pharmacological activity similar to Risperidon.

Elimination

Risperidon and its metabolites are eliminated in the urine and partly more than in the feces. Risperidon's apparent sale time is 3 hours in strong metabolic and 20 hours in weak metabolic people. The apparent selling time of 9 - Hydroxyrisperidon is 21 hours in rapid metabolic and 30 hours in slow metabolic people. The pharmacokinetics of the substance are active, after using single or multi -dose with the average selling time of about 20 hours.

Before taking Risperstad 2 Stella medicine for acute and chronic mental disorder (6 blisters x 10 tablets)

How to use

Risperstad is used by oral, not affected by food; Use 1 time/day or divided into 2 times/day.

Dosage

Adults

schizophrenia: The usual oral dose of risperidon is 2 mg/day, can be increased to 4 mg/day on the 2nd day, and adjust the dose later if needed with a dose of 1 mg or 2 mg if tolerated and after a period of not less than 24 hours. Most patients respond well at a dose of 4 - 6 mg/ day. Risperidon can be used once a day or divided into 2 ease/day. The maximum dose is 16 mg/day.

Halfy in bipolar disorder: The recommended starting dose is 2-3 mg/time/day. The dose can be increased by 1 mg/day after a period of not less than 24 hours to a total dose of 6 mg/day.

Children

Smen schizophrenia treatment in teenagers aged 13-17, short -term treatment for acute mania or a mixture of bipolar disorders in children and teenagers aged 10-17 years old, treatment to be stimulated related to autism disorders in children from 5 to 16 years old.

schizophrenia and revival: The starting dose of 0.5 mg x 1 time/day in the morning or evening. The dose can be increased with a dose of 0.5 mg or 1 mg if tolerated, after a period of not less than 24 hours, to a dose of 3 mg/day for schizophrenia or 2.5 mg/day for Hung Giac disease. The maximum dose recommended for both indicated above is 6 mg/day. The total daily dose can be divided into 2 doses for patients with long -term drowsy.

Sales of irritation is easy to be related to autism: Use 1 time/day or 2 times/day based on weight:

20 kg: The starting dose is usually 0.5 mg/day, can increase to 1 mg/day after at least 4 days and adjust the dose later if needed with a dose of 0.5 mg, usually no less than 2 weeks. The maximum recommended dose is 2.5 mg/day in children over 20 kg and 3 mg/day in children over 45 kg.

Pediatric patients have long -lasting drowsy, should be used once before sleeping or divided into 2 times/day, or reducing the dose.

Older patients or weak patients

Starting dose 0.5 mg x 2 times/day, if necessary, increase the dose slowly 0.5 mg/2 times/day to 1-2 mg/2 times/day. Dosage of over 1.5 mg/2 times/day, increased dose should be done after at least 1 week.

Hepatic failure and kidney failure

Risperidon's recommended starting dose for patients with renal impairment or liver failure is 0.5 mg/2 times/day, if necessary, the dose should be increased slowly 0.5 mg/2 times/day to 1 - 2 mg x 2 times/day. Dosage over 1.5 mg x 2 times/day, the increase in the dose should be done after at least 1 week.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Consider gastric lavage and active carbon use with a lottery only when taking the medicine for no more than 1 hour earlier. Cardiovascular should be monitored immediately and electrocardiograms to detect the possibility of arrhythmia.

There is no specific detoxification for Risperidon should apply appropriate support measures.

Lagging blood pressure and circulatory failure should be treated with appropriate measures such as infusion and/or using sympathetic drugs. In the event of a severe symptom of outsider, anti -cholinergic drugs.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Risperstad 2, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Insomnia, anxiety and headache.

Uncommon, 1/1000

Indigestion, nausea and vomiting, abdominal pain, constipation, blurred vision, sexual dysfunction including penis, uncontrolled urination, skin rash and other allergic reactions, chicken sleep, difficulty focusing, dizziness, fatigue and rhinitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Risperstad 2 drugs are contraindicated in the following cases:

sensitive to Risperidon or any ingredients of the drug.

Be cautious when using

Serious side effects, including an increase in the risk of death, has been reported in older patients using Risperidon or other typical anti -psychotic drugs in clinical trials in mental disorders related to intellectual dementia. Risperidon is not used to treat mental disorders related to dementia.

Due to the possibility of posture hypotension, caution should be used in patients with cardiovascular disease, cerebrovascular disease, which can lead to hypotension in patients and patients who are taking antihypertensive drugs.

Due to the risk of serious hyperglycemia, sometimes accompanied by keto acid infection, coma due to osmosis, or death has been reported in patients using Risperidon. Patients with diabetes earlier when treated with typical anti -psychotic drugs should be closely monitored by the deterioration of blood glucose control at the beginning of treatment; Patients with risk factors for diabetes should check blood sugar at hunger at the beginning of periodic treatment later.

Patients with Parkinson's symptoms or intellectual decline can use anti -psychotic drugs, including RisParidon, which has been reported to increase the sensitivity of anti -psychotic drugs.

Be careful to use Risperidon for patients with cardiovascular disease, including conditions associated with extending T, or conditions that lead to hypotension. It is recommended that patients should be cautious if there is a history or risk of progression of cerebrovascular disease, patients with Parkinson's or epilepsy, and patients with liver or renal failure. It is advisable to stop risperidon slowly due to the risk of symptoms of stopping drugs, including sweating, nausea and vomiting, and mental rebellion when the drug is stopped suddenly. Lactose -containing film tablets, which should not be used for patients with rare genetic problems such as galactose intolerance, Lapp Laclase deficiency or Glucose - Galaclose.

The ability to drive and operate machinery

Risperidon can reduce the ability to judge, think or motor skills, patients should be cautious when operating dangerous machinery, including motorbikes, until sure that Risperidon does not cause the above unwanted effect.

Pregnancy

There is no adequate and controlled research on pregnant women. Risperidon is only used during pregnancy when the potential benefits are superior to the possibility of fetal harm.

Breastfeeding period

In animal studies, Risperidon and 9 - Hydroxyrisperidon is excreted in milk, Risperidon and 9 - Hydroxyrperidon are also excreted into breast milk. Therefore, women are treating with Risperidon should not breastfeed.

Medicinal interaction

should be cautious when taking Risperidon along with other drugs that affect the central nervous system and Alcohol.

Due to the risk of hypotension, Risperidon may increase the hypotension of drugs that can cause hypotension.

Risperidon can fight the action of IEVodopa and dopamine homogeneous substances. Long -term use of clozapin along with risperidon can reduce the clearance of risperidon.

Risperidon sharing with carharnazepin and other liver carved drugs (such as phenytoin, rifampicin, phenobarbital) can reduce the coordination concentration of risperidon and 9 - hydroxylididon in plasma, so it can reduce the treatment effect of risperidon.

Fluoxetin and paroxelin increases the levels of risperidone in plasma 2.5 - 2.8 times and 3-9 times respectively. Fluoxetin does not affect the concentration of 9 - hydroxylpleridon in plasma. Paroxetin reduces the concentration of 9 - Hydroxyrisperidon average about 13%. When shared with fluoxetin or paroxetin at the beginning or discontinue treatment should re -evaluate the dose of risperidon.

Storage

In closed packaging, dry place, avoid light, temperature not exceeding 30 ° C.

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