Ritozol 40mg Bosch medicine for gastroesophageal reflux treatment (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Esomeprazole

Ingredient

Composition information	Content
Esomeprazole	40mg

Uses

Indications

Ritozol 40mg pills are indicated in the following cases:

Treatment of gastroesophageal reflux disease (GERD)

Treatment of scratched esophagitis: Ritozol is indicated for short -term treatment (4 - 8 weeks) to treat and reduce the symptoms of scratched esophagitis. For patients who do not help after 8 weeks of treatment, one more treatment can be used with Ritozol 8 more weeks. Back to the esophagus. Patients who are at risk of ulcers are over 60 years old and/or have a history of stomach ulcer. (There is a history of or being in the past 5 years) to kill H. Pylori. The eradication of H. Pylori shows a reduction in the risk of duodenal ulcer, in patients with failure, testing sensitivity should be done. If resistance to clarithromycin or testing inappropriate sensitivity, should replace treatment with other appropriate antibiotics. Learning

Esomeprazole is the isomorphic form of omeprazole, proton pump inhibitors. Esomeprazole prevents stomach acid secretion by inhibiting specific H +/K +- ATPase in the gastric cell wall. Because of the special impact on proton pump inhibition, Esomeprazole prevents the final level of acidic excretion, thus reducing the acidity in the stomach.

pharmacokinetic

absorption

After taking the peak concentration in plasma (CMAX) achieved after about 1.5 hours (TMAX). CMAX increases proportional to increase. The area under the curve (AUC) increased 3 times when using the dose of 20 to 40 mg. At the daily dose of 40 mg daily, the whole body uses about 90% when compared to the single dose of 40 mg is 64%.

The area under the curve (AUC) after taking a single -dose of 40 mg Esomeprazole decreases 43 - 53% after use with food when compared to fasting conditions. Esomeprazole should be used for at least 1 hour before meals. The food slows down and reduces the absorption of Esomeprazole, but this does not significantly change its effects and stomach acid secretion.

Distribution

Esomeprazole clings to 97%plasma proteins. The integral distribution in a stable situation on healthy volunteers is about 16L.

Metabolism

Esomeprazole is completely transformed through the Cytochrome P450 (CYP) system. The metabolite of Esomeprazole lacks anti -secret activity. The main part of Esomeprazole metabolism depends on isenzyme CYP2C19, forming Esomeprazole's hydroxy and desmethyl metabolites. The rest depends on CYP3A4 to form sulphone metabolites.

Elimination

The main semi -discharged time in the plasma of Esomeprazole is approximately 1 - 1.5 hours. Less than 1% of the drug in constant form is eliminated into the urine. About 80% of the doses of Esomeprazole are taken in the form of inactive metabolites in the urine, the rest is found in the form of inactive metabolites in the feces.

Before taking Ritozol 40mg Bosch medicine for gastroesophageal reflux treatment (2 blisters x 7 tablets)

How to use

This drug is only used as prescribed by a physician.

Esomeprazole capsules should swallow whole and drink before meals 1 hour.

Dosage

adults:

Gastroesophageal reflux (GFRD):

Healing scratches of esophagitis: 20 mg or 40 mg, once a day for 4 to 8 weeks. (NSAID): 20 mg or 40 mg, once daily for 6 months.

Esomeprazole: 40 mg, once a day for 10 days.

Amoxicillin: 1000 mg, twice a day for 10 days.

Short -term treatment of gastroesophageal reflux disease - esophagus: 20 mg or 40 mg, once a day until 8 weeks.

Elderly patients: No dose adjustment. For patients with severe liver failure (Child Pugh C), do not exceed the dose of 20 mg.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose

Side Effects

When using Ritozol 40 mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: headache, dizziness, rash.

Systemic: Insomnia, fatigue, drowsiness, itching.

Systemic body: fever, increased sweating, peripheral edema, light sensitive reaction and hypersensitivity reaction including: urticaria, angioedema and shock, anaphylactic reaction. liver enzyme, hepatitis, with or without jaundice, liver failure. guide how to handle ADR

Notify the doctor with unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Ritozol 40 mg contraindicated in the following cases:

Patients are sensitive to Esomeprazole or any ingredients of the drug or Benzinmidazole instead.

Light sensitivity reaction, for example, angels and shock or anaphylactic reactions are reported when using ritozol.

Precautions when using

When there is the presence of any alert symptoms (for example, significant weight loss, recurrent vomiting, difficulty swallowing, vomiting of blood or black defecation) and when suspected or gastric ulcer should eliminate malignant diseases because treatment with Esomeprazole may slightly reduce symptoms and delay the diagnosis. Patients with long -term treatment (especially for more than a year) should be monitored regularly.

The ability to drive and operate machinery

No observation has any impact.

Pregnancy

There has been no appropriate research on adequate control in pregnancy. Only use this medication during pregnancy when really necessary.

Breastfeeding period

There is no study of Esomeprazole excretion in breast milk. Esomeprazole ability to excrete in breast milk. Should take into account the importance of the drug for the mother when deciding to stop breastfeeding or stopping the drug.

Drug interaction

Esomeprazole is widely metabolized in the liver. Drug interaction research shows that Esomeprazole has no significant clinical interactions with Phenytoin, Warafin, Quinidine, Clarithromycin and Amoxycilin. Esomeprazole can affect the bioavailability of pH -dependent absorption drugs (for example, ketoconazole, iron salt, digoxin).

Storage

Avoid light and moist. Store at room temperature.

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