Rofcal OPC drug prevents and treats osteoporosis (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Calcitriol

Ingredient

Composition information	Content
Calcitriol	0.25mcg

Uses

indications

Rofcal drug are indicated in the following cases:

Prevent and treat osteoporosis including osteoporosis caused by corticosteroids.

rickets due to nutrition, rickets due to metabolism (rickets respond to vitamin D, rickets resistant to vitamin D, accompanied by reduction of blood phosphate), bone puree.

The parathyroid defect (primary or after surgery), minimizing parathyroid gland.

Kidney dysplasia in patients chronic kidney failure , especially patients treated with artificial dialysis.

In patients with rickets that do not respond to vitamin D (rickets decrease in primary blood phosphate), in combination with low calmcitriol levels in plasma, calcitriol helps reduce the elimination of phosphate through the renal tubules and normalize bone formation.

In people with renal failure, rickets depend on vitamin D: endogenous calcitriol synthesis is limited, Calcitriol is considered as an alternative treatment.

In people with parathyroidism and hypoglycemia, which causes blood calcium: additional calcitriol supplements will mitigate clinical manifestations.

Dynamic pharmacokinetics

absorption: Calcitriol is quickly absorbed in the intestine. After taking the only dose of 0.25mcg to 1mcg Calcitriol, the maximum concentration achieved after 3-6 hours. After repeated drink, Calcitriol's concentration in serum reaches equilibrium in 7 days. Calcitriol has an exogenous origin through the placenta fence and excreted through breast milk. Calcitriol's excretion half-life is about 3-5 days, and 40% of treatment dose is excreted within 10 days.

Elimination: Calcitriol is excreted through bile and influenced by the liver - intestinal cycle, excreted through feces and urine.

In patients with nephrotic syndrome or in people who undergo dialysis, calciiol content decreases in the serum and time to achieve the peak content also prolonged.

Before taking Rofcal OPC drug prevents and treats osteoporosis (3 blisters x 10 tablets)

How to use

Take medicine with water.

Dosage

should be carefully determined based on the calcium concentration in the serum of each patient. During treatment, it is necessary to try the calcium concentration in serum at least 2 times per week. If the hypercalcemia occurs, the medication should be discontinued to return the serum calcium concentration to normal, then it may continue to treat with lower calcitriol dose than the dose that causes hypercalcemia.

osteoporosis:

Take 1 tablet at a time, twice a day. After 2-4 weeks, if the therapy is not effective, the dose can be increased to 2 capsules each time, twice a day.

Armor and fake disabilities with parathyroidism, rickets, bone puree:

The starting dose is 1 tablet daily in the morning. After 2-4 weeks, if there is no good response to biochemical parameters and the clinical manifestations of the disease remain, it can increase the dose to 1 tablet, 2 times a day.

Kidney dysplasia (artificial dialysis patients):

The starting dose is 1 tablet per day. After 2-4 weeks, if there is no good response to biochemical parameters and the clinical manifestations of the disease remain, it can increase the dose to 1 tablet, 2 times a day. For patients with normal calcium concentration or slight decrease, the starting dose is 1 tablet every 2 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

The overdose treatments caused by the wrong oral intake include: Stomach was immediately or caused to avoid absorbing the drug into the bloodstream. Use paraffin oil to increase the elimination of the drug. Conduct multiple blood calcium tests. If blood calcium is still high, can use phosphate or corticosteroids and use appropriate urinary measures.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Rofcal , you may experience unwanted effects (ADR).

There is no side effects when taking the right dose.

If using a high -dose Rofcal can cause adverse effects similar to vitamin D overdose (blood calcium hypercactive syndrome or calcium poisoning, depending on the degree and time of hypercalcemia).

Symptoms such as: weak, tired, sleeping, headache , anorexia, dry mouth, metal flavor, nausea, vomiting, cramps in the abdomen, constipation , diarrhea , dizziness, tinnitus , loss of air conditioning, foreign rash, reduced muscle tongue, muscle pain, bone pain, and ease of stimulation. In patients with normal renal function, when serum calcium levels increase for a long time, there may be an increase in serum creatinine levels. If there is also hypercalcemia and blood phosphate, which may be calculated with soft tissues.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Rofcal medicine contraindicated in the following cases:

All disorders are associated with increased serum calcium concentration.

Patients with symptoms of Vitamin D. poisoning symptoms

Be cautious when used

Be cautious when used for sarcoidosis or parathyroidism (which can cause increased sensitivity to vitamin D), renal function (the risk of calcification calcification caused by inorganic phosphate in serum), heart disease, kidney stones, atherosclerosis.

Pay attention to the risk of hypercalcemia in people with immobile illness (such as after surgery), who is using non -control preparations containing calcium.

People with normal kidney function when using Calcitriol: Need to avoid dehydration, maintain appropriate fluid supply.

During pregnancy and lactation, children under 3 years old, children are being treated with artificial kidneys: Caution when using.

The ability to drive and operate machinery

does not affect.

Pregnancy

Although there is no evidence that Calcitriol causes deformities in the fetus, even at very high doses, should only be used when they have considered benefits and harm to the fetus.

breastfeeding period

Calcitriol is excreted through breast milk. The mother can breastfeed when used, but need to closely monitor serum calcium in both mother and child.

Interactive drug

Do not use pharmacological doses of vitamin D and its derivatives, or use without control of calcium -containing preparations while using calcitriol to avoid synergistic effects and increase blood calcium.

Use in combination with thiazide diuretic: increased blood calcium hypercalcium risk.

Use in combination with digitalis: It is necessary to consider because of hypercalcemia causing arrhythmia.

Use in combination with corticosteroids: antagonistic effects caused by corticosteroids reduces calcium absorption.

Mg -containing medications (such as antacids): can cause increased mg content in the blood, so it is not used for people who are being treated with Calcitriol with chronic kidney disease to be fertilized.

Use in combination with preparations containing phosphate may increase excess phosphate.

Vitamin D -resistant rickets (reducing blood phosphate): it is necessary to continue taking phosphate but must check the serum phosphate concentration if using Calcitriol.

Phenytoin, phenobarbital (liver enzyme induction): increases metabolism, reduces the level of calcitriol in serum, so it is necessary to increase the dose of calcitriol.

Cholestyramin, Colestipol hydrochloride, excessive mineral oil can hinder the absorption of Calcitriol in the intestine.

Storage

Keep the drug in a closed box, leave a cool dry place, temperatures below 30 ° C, avoid light.

OPC Pharmaceutical Joint Stock Company was established from 1977, with the mission:

Providing high quality, breakthrough products, meeting the needs of public health care and protection.

Create meaningful jobs, educate workers with respect, love and responsibility for life, people and society.

Bring added value and practical benefits to customers, shareholders and consumers.

contribute to enhancing the position of traditional medicine and pharmaceutical industry in Vietnam.

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