Rohcerine drugs 50mg Windlas Biotech treat hip degeneration, knee (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Diacerein

Ingredient

Composition information	Content
Diacerein	50mg

Uses

indications

Rohcerine drugs are indicated in the following cases:

Symptomatic treatment for patients with hip or knee osteoarthritis, with slow effects.

It is not recommended for diacerein treatment for patients with degenerative osteoarthritis that progresses rapidly because these patients can respond weakly with diacerein. Good in the stomach because the drug does not inhibit the synthesis of prostaglandin.

Diacerein is a drug that can affect both assimilation and catabolism of cartilage cells and reduce inflammatory factors.

The results of some studies in-vitro and in-vivo showed that Diacerein and Rhein, a metabolic substance with its activity, inhibit the production and activity of Cytokine Il-1β inflammation and money, both in the shallow layer and deep layer of cartilage, in the epidemic membrane and the epidemic membrane while stimulating the production factor of the form of growth. Proteoglycan, Aggrecan, Hyaluronic Acid and Type II glue.

In addition, these substances also show inhibition of macrophages and movement of macrophages.

Studies in some animal osteoarthritis models show that diacerein reduces cartilage degeneration compared to untreated groups.

pharmacokinetic

absorption

After using a single dose of 50mg of diacerein, the peak plasma concentration is achieved after 2.5 hours, about 3 mg/l. The pharmacokinetics parameters do not depend on the dose when using Diacerein dose in the range of 50mg - 200mg. Used with food increases 25% of the absorption capacity. Therefore, should share diacerein with food.

Distribution

Rhein (Diacerein's active metabolites) connect 99% with plasma albumin, a smaller amount associated with lipoprotein and immunoglobulin gamma. The epidemic concentration reaches 0.3 to 3.0 mg/l.

Metabolism

Diacerein is strongly metabolized (100%) in the liver after oral, diacerein will be reduced to acetyl to form an active metabolic substance.

Elimination

Diacerein excreted urine in the form of metabolism in the range of 35% - 60%, of which about 20% in the form of free Rhein and 80% are compounds of Rhein.

Before taking Rohcerine drugs 50mg Windlas Biotech treat hip degeneration, knee (3 blisters x 10 tablets)

How to use

Rohcerine drugs are taken orally.

Should take the medicine with the meal (one pill at breakfast and the other for dinner). The drug must be swallowed intact (do not break the drug) with 1 glass of water.

Dosage

The use of diacerein should be started by a doctor who has experience in treating osteoarthritis.

Because some patients may have loose or diarrhea, Diacerein's recommended starting dose is 50 mg once a day at dinner for the first 2-4 weeks. Then can increase to 50 mg x 2 times/ day.

Special subjects

Patients with creatinine clearance

Diacerein recommendations for patients over 65 years old.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no specific antidote. If there is a prolonged diarrhea, see a doctor.

Emergency treatments include restoration of water - electrolytes if necessary.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Rohcerine, you may experience unwanted effects (ADR).

Signs and symptoms after overdose diacerein include:

diarrhea, nausea, vomiting, rash, itching, epigastric pain, urine discoloration. If you become serious, need symptom treatment.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Rohcerine drugs contraindicated in the following cases:

In patients with hypersensitivity to the drug or before that has been hypersensitively to Anthraquinon's derivatives. intestinal tract (ulcerative colitis, Crohn disease).

Precautions when using

diarrhea

Diacerein taken regularly can cause diarrhea, thereby leading to dehydration and hypokalemia. Patients should stop using diacerein when diarrhea and exchange with the doctor for treatment of alternative treatments.

Diacercin should not be prescribed for children under 15 years old because there is no clinical research that has been conducted at this age.

Liver system disorders

Cases of acute liver lesions, including liver enzyme hyperplasia and cases of hepatitis related to diacerein have been reported during after -sales. Most of these cases occur in the first months at the beginning of treatment. Need to closely monitor the signs and symptoms of liver damage in patients.

Children

Diacerein pharmacokinetics have not been studied in children, so it is not recommended for children under 15 years old.

Older people

Diacerein micro can be used with food, so there is no need to adjust the dose in the elderly even though the clearance may be slower.

The ability to drive and operate machinery

does not affect the ability to drive and operate machinery.

Pregnancy

should not use diacerein for pregnant women.

Lactation period

Diacerein pharmacokinetics have not been studied in nursing women, so it is not recommended to use.

Drug interaction

Diacerein is known to be interacting with other drugs such as aluminum hydroxide and aluminum oxid, psyllium.

The drug is reduced when combined with aluminum and/or antacids such as Magnesi Hydroxid.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Other drugs

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