Rostor medicine 10mg Pymepharco treatment for increased cholesterol (2 blisters x 14 tablets)

Dosage form Box of 2 blisters x 14 tablets
Specifications Rosuvastatin

Ingredient

Composition information	Content
Rosuvastatin	10mg

Uses

indications

Rostor 10 mg drug is indicated in the following cases:

Increasing cholesterol primary (type IIA including hyperlested hyperlyonic blood cholesterol) or mixed blood lipid disorders (type IIB): is a supportive therapy for diet when the patient does not fully respond to diets and other non -drug therapies (exercise, weight loss).

Hyperlipitium hyperlested hypertension: Use to support diets and other lipid reducing treatments (blood ldl excerpts) or when these therapies are not appropriate.

Pharmacokology

Rosuvastatin is a selective and competitive inhibitor HMG - CoA Reductase, a catalyst of conversion process 3 - hydroxy - 3 - methylglutaryl coenzyme A into Mevalonate, the precursor of cholesterol. The main acting position of rosuvastatin is the liver, the target organs reduce cholesterol.

Rosuvastatin increases the number of LDL receptors on the surface of liver cells, thus increasing the absorption and catabolism of LDL, inhibiting VLDL synthesis in the liver, reducing VLDL and LDL components.

pharmacokinetics

absorption:

Rosuvastatin's peak plasma concentration is about 5 hours after drinking. Absolute bioavailability of about 20%.

Distribution:

Rosuvastatin is widely distributed in the liver, which is the main place to synthesize cholesterol and LDL - C. The distribution volume is about 134L. About 90% of rosuvastatin combined with plasma proteins, mainly with albumin.

Metabolism:

Rosuvastatin is less metabolized (about 10%). The main metabolites are identified as N - Desmethyl and Lacton. N - Desmethyl metabolites have a weaker activity about 50% than rosuvastatin while lacton form is not clinically active. Rosuvastatin accounts for more than 90% of HMG inhibitors - CoA Reductase in circulation.

Era:

About 90% of the dose of rosuvastatin is eliminated in a constant form, the rest is excreted into urine. Selling time for plasma is about 19 hours. The average plasma clearance is about 50 l/hour.

Like other HMG - Coa Reductase inhibitors, the transportation of rosuvastatin through the liver requires the transportation through Oatp - C. This transportation is important in eliminating rosuvastatin through the liver.

Before taking Rostor medicine 10mg Pymepharco treatment for increased cholesterol (2 blisters x 14 tablets)

How to use

Take pills with filtered water.

Dosage

Before the beginning of treatment, the patient must follow the standard diet to reduce cholesterol and continue to maintain this diet during treatment.

The recommended starting dose is 5 mg or 10 mg, once a day. The starting dose depends on the cholesterol level of each patient, the future of cardiovascular risk as well as the possibility of unwanted side effects.

Can adjust the dose every 4 weeks if needed. The 40 mg dosage should be considered only in patients with severe hypercholesterolemia that is at high risk of cardiovascular disease (especially patients with hypertonic blood cholesterol), without achieving treatment goals at the dose of 20 mg and should be monitored regularly in these patients.

The elderly: Should start the starting dose of 5 mg/day.

Patients with renal failure:

Creatinine clearance (cc) 30 - 60 ml/minute: initial dose 5 mg/time/day and a maximum dose of 20 mg/day/day.

Creatinine clearance (cc)

Children: Safety and effectiveness have not been established.

Combined treatment: Rososvastatin dose limit up to 10 mg/time/day when used simultaneously with Atazanavir, combined Atazanavir and Ritonavir, combined Lopinavir and Ritonavir.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

There is no specific treatment for overdose.

When an overdose, patients should be treated with symptoms and apply supportive measures when necessary. Should monitor liver function and ck concentration. Blood decomposition may not benefit.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Rostor 10 mg , you may experience unwanted effects (ADR).

Common, ADR> 1/100:

headache , dizziness, nausea, abdominal pain, muscle pain, weakness .

Rare, 1/10000

Hypersensitivity including angioedema, muscle disease, muscle pilot, joint pain, hyper enzyme, multiple nerve disease, cognitive impairment (memory loss, confusion ...), hyperglycemia, HBA1C.

Notice immediately to the doctor the unwanted effects when taking the drug.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Rostor 10 mg contraindicated in the following cases:

Patients with hypersensitivity to the ingredients of the drug.

Patients with progressive liver disease, including prolonged increase in serum transaminase and unknown cause and when serum transaminase concentration increases more than 3 upper limits of normal levels (ULN).

Severe renal failure (Creatinine clearance

Patients with muscle disease.

are using cyclosporin.

Pregnant and lactating women.

Be cautious when used

Nose reduction in patients with renal failure and monitoring kidney function during monitoring of patients who have been treated at a dose of 40 mg.

Caution for elderly patients.

Do not use rosuvastatin in patients with acute serious condition, suspicion due to muscle disease or lead to secondary renal failure due to muscle prize (blood pressure, hypotension, surgery, trauma, metabolic disorders, hormonal, and severe conversion, uncontrolled convulsions).

do liver enzyme test before treatment and in case of clinical indications for testing later.

Consider monitoring Creatin Kinase (CK) in the case:

Before treatment, CK tests should be conducted in the following cases: impaired renal function, hypothyroidism, self -history or family history of genetic diseases, a history of disease due to statin or fibrat before, a history of liver disease and/or drinking a lot special.

In these cases should consider benefits/risks and monitor patients clinically when treated with statin. If the results of CK test> 5 times the upper limit of normal levels, do not start treatment with statin.

During statin treatment, patients need to notify when there are muscle manifestations (muscle pain, muscle stiffness, muscle weakness ...). When there are these manifestations, patients need to test CK to take appropriate interventions.

The ability to drive and operate machinery

Dizziness can occur so cautious when driving and operating machinery.

Pregnancy

Contraindicated in this object.

Breastfeeding period

Contraindicated in this object.

Drug interaction

antagonistic substances vitamin K (warfarin): can increase Inr when used simultaneously.

Increased risk of muscle damage when used simultaneously with the following drugs: Gemfibrozil, other fibrat blood cholesterol medications, high -dose niacin (> 1 g/day), Colchicin.

Anti -acid drugs: Concomitance with aluminum anti -aluminum oral mixture and Magnesi Hydroxid reduces about 50% of plasma rosuvastatin levels.

Simultaneous use of rosuvastatin with erythromycin reduces about 20% AUC and 30% cmax of rosuvastatin, may be due to erythromycin, which increases intestinal motility.

Hormonal contraceptives/ hormone replacement therapy: will increase 26% AUC of Ethinyl Estradiol and 34% AUC of Norgestrel when used simultaneously.

Simultaneously used with protease inhibitors of HIV and hepatitis C (HCV) can increase the risk of muscle damage, the most serious is muscle pattern, kidney damage leads to renal failure and can be fatal: limit Rosuvastatin dose maximum 10 mg/time/day when using Atazanavir simultaneous Ritonavir.

Storage

In a cool dry place (below 30 ° C), avoid light.

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