RULID 150mg Aventis treats all kinds of infections, diphtheria, and pertussis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Roxithromycin

Ingredient

Composition information	Content
Roxithromycin	150mg

Uses

indications

Rulid drug are indicated in the following cases:

Priority is used to treat bacterial infections caused by Mycoplasma Pneumoniae and Legionella diseases.

Pharmacokology

Roxithromycin is a macrolide antibiotic, has a broad spectrum with Gram -positive bacteria and a few Gram -negative bacteria.Roxithromycin clinically is often effective for Streptococcus Pyogenes, S. Viridans, S. Pneumoniae, Staphylococcus Aureus Aureus sensitive Methicilin, Bordetella Pertussis, Branhamella CatVrhalis, Coryenebacterium Diphteriae, Mycoplasma Pneumoniae, Chlamydia Trachomatis, Legionella Pneumophilia, Helicobacter Pylori and Borrelia Burgdorferi.

Due to the resistance of drug development in Vietnam, it is necessary to carefully evaluate the effect of the drug on each bacterium.

Roxithromycin can be considered as Erythromycin replacement drugs with more reliable biological available when drinking, and less problems with the digestive system.

Dynamic pharmacokinetics

absorption

Roxithromycin absorbs after oral for birth with about 50%. The peak concentration of plasma is about 6 - 8 mg/ml reaches 2 hours after a single dose of 150 mg. The absorption of the drug is reduced when taken after meals.

distribution

The drug is widely distributed in tissue and body fluid. The combination with plasma proteins is about 96% (mainly α1 - glycoprotein). Roxithromycin penetrates well into cells and body compartments. In particular, reaching high concentrations in the lungs, tonsils, sinuses, prostate, uterus. Roxithromycin does not pass the blood -brain barrier.

Elimination

Because Roxithromycin is excreted mainly through metabolism in the liver and the metabolites are discharged through bile and fertilizer, the normal dosage can be used for kidney disabled people.

Before taking RULID 150mg Aventis treats all kinds of infections, diphtheria, and pertussis (1 blister x 10 tablets)

How to use

Rulid 150mg drug preparation of film tablets for drinking before meals.

Dosage

Adults: Daily dose is 150 mg, taken 2 times/day before meals. Do not use for more than 10 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

No specific antidote.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Rulid , you may experience unwanted effects (ADR).

Digestive: Nausea, vomiting, stomach pain, diarrhea .

dizziness, headache , abnormal tactile.

Infold with some liver enzymes (ASAT, ALAT)

Rarely cholestatic hepatitis (liver damage is not caused by bacterial super bacteria).

Finished expression of serious allergies: urticaria , angioedema (face and neck edema suddenly combined with hives and/or shortness of breath), short breath allergic reactions: rash, urticaria, rarely have hemorrhage (small spots on red or blue skin)

Instructions on how to handle ADR: notify the doctor or pharmacist all unwanted effects when using this drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Rulid drug contraindicated in the following cases:

Already allergic to macrolid (erythromycin and drugs of the same group)

in combination with ergotamine and dihydroergotamine (medications for migraine).

Coordinate with Cisaprid (anti-reflux drugs)

Collaborate with terfenadin or astemisol due to the risk of life -threatening arrhythmia.

breastfeeding women are using Cisaprid.

Be cautious when using

must be especially cautious when using Roxithromycin for people with severe liver disabled. Due to glucose, this drug should not be used in the case of poorly absorbent glucose and galactose syndrome, caution in diabetics.

The ability to drive and operate machinery

can endanger the driver and use machines due to dizziness.

Pregnancy

only used for pregnant women when really necessary, although there is no document that mentions Roxithromycin causing birth defects.

breastfeeding period

Roxithromycin excreted milk with very low concentrations.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Combining Roxithromycin with one of the following drugs: Astenisol, Terfenadin, Cisaprid, capable of causing severe arrhythmia. Therefore, these drugs are not coordinated for treatment.

There is no significant interaction with Warfarin, Carbamazepin, Ciclosporin and oral contraceptives.

Increase the concentration of theophylin or ciclosporin in plasma, but there is no need to change the usual dose.

may increase the concentration of non -linked disoperamid concentration in serum.

Do not coordinate with bromocriptin because Roxithromycin increases the concentration of this drug in plasma.

To avoid interactions that may occur with many drugs, always inform the doctor or pharmacist of all other drugs.

Storage

In a dry place, temperatures below 30 ° C, avoid light.

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