S-Cort Tablet 100mg Schnell treat stomach ulcers, gastric mucosa damage (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Rebamipide

Ingredient

Composition information	Content
Rebamipide	100mg

Uses

Indications

drugs - cort are indicated in the following cases:

Treatment of gastric ulcer.

Pharmacological group: Gastrointestinal medicine.

In animals, Rebamipid has the effect of healing or preventing stomach ulcers, increasing prostaglandin, protecting the stomach lining, increasing mucus, increasing blood flow to the stomach lining. Increasing alkali secretion in the stomach, increasing mucosal cells, reducing the amount of peroxid lipid in the gastric mucosa. Rebamipid does not change the basic gastric secretion and acid secretion due to stimulant.

Rebamipid is used orally, inhibits the production of Interleukin - 8 in the mucosa of the patient with Helicobacter pylori. Rebamipid also inhibits the activity of NF - KB, and the production of Interleukin - 8 in the cultured epithelial cells simultaneously with Helicobacter Pylori.

pharmacokinetics

Plasma concentrations: After taking a single dose of a single dose of 100 mg Rebamipid in healthy men 100 mg, Tmax is 2.4 ± 1.2 hours, cmax is 216 ± 79 ng/ml for T1/2 is 1.9 ± 0.7 hours and AUC24 is 874 ± 209 ng.

Food does not affect human bioavailability. The pharmacokinetics parameters in patients with renal failure after taking the single dose of Rebamipid 100 mg show that plasma concentrations are higher and the selling time is longer than healthy people. In a stable state, Rebamipid's plasma concentration in dialysis patients after re -use is very close to the value of one dose. So the drug is considered not accumulated.

Metabolism

Rebamipid is excreted mainly in the form of unchanged urine after taking a single dose in healthy men at a dose of 600 mg. The metabolites with a group of hydroxyl in the 8th place are found in the urine. However, the excretion of this metabolite is only 0.03% of the dose. The enzyme involves the formation of metabolites is CYP3A4.

Excretion

About 10% of the dose is excreted into urine when Rebamipid is used for a single dose of 100 mg for healthy men.

Protein cohesion: Rebamipid at a concentration of 0.05 - 5 mcg/ml is added to In vito plasma and 98.4 - 98.6% of the drug is connected to plasma proteins.

Before taking S-Cort Tablet 100mg Schnell treat stomach ulcers, gastric mucosa damage (10 blisters x 10 tablets)

How to use

Scort drugs are used orally.

Dosage

Gastric ulcer: 1 tablet (Rebamipid 100 mg) three times a day: morning, afternoon and before sleep.

Improve the damage to the gastric mucosa (erosion, hemorrhage, red and edema): Take 1 tablet (Rebamipid 100 mg), 3 times/day in adults with acute gastritis or acute attacks of chronic gastritis.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

In an effective study for stomach ulcers, one reported a case of abdominal pain among 81 patients using Rebamipid 900 mg/day (maximum dosage in this study). There are very little information about overdose in the reporting report after being marketed.

How to handle

Overdose treatment is symptomatic treatment. Should continue to monitor closely until the patient recovers.

What to do when forgetting a dose?

Side Effects

When using drugs - cort , you may experience unwanted effects (ADR):

Clinically important side effects: shock, anaphylactic reaction*: shock or anaphylactic reaction may occur. Therefore should monitor patients carefully. If an abnormal detection is detected, Rebamipid should be discontinued and have appropriate measures.

Lack of leukocytes (ratio

Liver dysfunction (ratio

Other side effects: Hypersensitivity: ratio Mental*: numb, dizziness, drowsiness. digestive: ratio liver: ratio Hematology: ratio Other: ratio

* Unknown side effects.

Instructions on how to handle ADR

Notify the physician with unwanted effects related to drug use.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

drug S - cort contraindicated in the following cases:

Patients with hypersensitivity or a history of sensitivity to rebamipid or other ingredients in this drug (excipients: crystal cellulose, hydroxypropyl cellulose, low substitulation hydroxypropyl cellulose, crossovidon, silicon dioxyd, magnesi stearate, talc, hydroxyproxyprose Polyethylene glycol 6000, titanium oxyd.).

Precautions when using

used in the elderly: It is necessary to be especially cautious in the elderly patients to minimize the risk of stomach disorders because of their physiological patients who are sensitive to Rebamipid than young patients.

Use in children: Rebamipid's safety in underweight children, infants, breastfed and children has not been proven.

The ability to drive and operate machinery

dizziness and sleep can occur. Patients should be careful when driving or operating machinery.

Pregnancy

The safety of Rebamipid in pregnant women has not been proven. Rebamipid should only be used for pregnant women or women may be pregnant when the expected treatment benefits are considered to be more than the risk.

Breastfeeding period

Rat studies show that Rebamipid is excreted in milk. Should stop breastfeeding when using Rebamipid.

Medicine interaction

Rebamipid less inhibits cytochrom p - 450 in vitro. Rebamipid is difficult to metabolize in the liver and excreted urine in a constant form; Therefore, the drug does not have much impact on the metabolism of other drugs. In terms of simultaneous use with other drugs with high protein cohesion rates (H2 and warfarin blockers), although Rebamipid has a high protein connection rate (≥ ≥ 95%), the blood level is very low of 200 ng/ml; Therefore, Rebamipid is considered to be less likely to increase concentration due to competition with other drugs.

In addition, there are reports that Rebamipid is not affected by Sericylic Acid (Human) at the time of taking aspirin, and concentration of 5 - fu in tumor tissue and plasma (mice) at the time of using UFT. There is no report on interact between Rebamipid and other drugs.

Storage

Store in closed packaging, avoid light, at temperatures below 300C.

To be out of reach of children.

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