Sadapron 300 Remedica medicine for hyperuricemia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Allopurinol

Ingredient

Composition information	Content
Allopurinol	300mg

Uses

Indications

Sadapron 300 mg remedica 3x10 is indicated in cases of treatment of primary and secondary hyper Uric acid hyperemia accompanied by gout, kidney disease with uric acid, uric acid recurrence, blood and cancer or cancer chemotherapy.

Pharmacokic

allopurinol is a xanthin-oxydase inhibitor. Allopurinol and its main metabolites oxipurinol reduce uric acid levels in plasma and urine by inhibiting xanthin oxydase, this enzyme catalyzes hypoxanthin oxidation into xanthin and xanthin into uric acid. The new purin biosynthesis is reduced by inhibition of Hypoxanthin-Guanin Phosphoribosyltransferase. Other metabolites of allopurinol are allopurinol-riboside and oxipurinol-7 ribosid.

pharmacokinetics

allopurinol is active when taken and quickly absorbed in the digestive apparatus. Studies have found that Allopurinol in the blood after taking 30-60 minutes. Bioions vary from 67 - 90%. The peak plasma concentration of Allopurinol is usually about 1.5 hours after drinking, but falls rapidly and almost no longer after 6 hours. Oxipurinol's peak blood concentration is usually about 3-5 hours after drinking allopurinol and lasts much longer.

Allopurinol is not significantly attached to plasma proteins and therefore the change in binding with plasma does not significantly change the waste coefficient. The apparent volume of Allopurinol distribution is about 1.6 l/kg, showing a relatively strong distribution in tissue. Human tissue has not been seen in human tissue, but may have the highest concentration in the liver and intestinal mucosa in which high xanthin oxidase activity. About 20% of Allopurinol has been deducted from the feces. The main metabolite of allopurinol is oxipurinol is also a Xathin oxidase inhibitor that has a half -life of plasma waste in about 15 hours or more in patients with normal kidney function.

oxipurinol inhibits xanthine oxidase weaker than allopurinol, but the time for the sale of plasma of oxipurinol is much longer. From 13 - 30 hours in humans. Therefore, the effective inhibition of xanthin oxidase is maintained for 24 hours with a single dose of Allopurinol. Patients with normal renal function accumulate oxipurinol gradually until a stable state concentration is reached. Such patients, using 100 mg of Allopurinol per day often have a plasma oxipurinol concentration 5 - 10 mg/l.

Dynamic pharmacokinetics in patients with renal impairment: Allopurinol and oxipurinol clearance coefficient in patients with renal impairment leads to higher plasma content when long -term treatment. Patients with renal impairment, in which the evaporation value of creatinine is from 10 to 20 ml/min, shows that plasma oxipurinol concentration is about 30 mg/l after long -term treatment with 100 mg of Allopurinol/day. This concentration can be achieved at a dose of 600 mg/day in people with normal renal function. Therefore, it is necessary to reduce the dose in patients with renal impairment.

Pharmacokinetics in elderly patients: This drug is not different because of the impaired renal function (please read the pharmacokinetic part in patients with renal impairment).

Before taking Sadapron 300 Remedica medicine for hyperuricemia (3 blisters x 10 tablets)

How to use

oral drugs. The best drink is after meals with a little water.

Dosage

Adults: The usual dose is 100 - 300 mg once a day. Then adjust the dose according to the concentration of uric acid in the blood. In cases weighing 600 - 900 mg daily are divided into several times.

Children: 10 - 20 mg/kg per day. The maximum dose of 400 mg. Little for children except for malignant cancer cases.

Elderly: In the absence of specific data, the lowest dose should be used to reduce Urat adequate.

renal failure: reduce the dose.

For severe renal failure: less than 100 mg per day or a single dose of 100 mg longer than a day. If you have to appraise 2-3 times/week, use immediately 300 - 400 mg immediately after each appraisal.

Hepatic failure: Dosage should be reduced in patients with liver failure. Recommended testing of liver function in the early stages of therapy. Continuous drugs even when you feel better. Your disease may get worse. Do not drink alcohol.

High doses of vitamin C can increase kidney stones. Consult your doctor before taking vitamin C.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? Symptoms include nausea, diarrhea, vomiting and dizziness. Should treat general support. Water compensation is just enough to maintain optimal diuretic to help excrete allopurinol and its metabolites. The dialysis can be necessary in severe cases.

What to do when forgetting a dose? However, if near the next dose, skip the forgotten dose and return to the normal medication schedule. Do not use double the dose.

Side Effects

When using Sadapron 300 mg Remedica 3x10, you may experience unwanted effects (ADR).

The most common side effect of Allopurinol is rash (rash or itching). The more severe hypersensitivity reactions such as scales, Stevens-Johnson syndrome and toxic skin necrosis. Allopurinol should be stopped if rash. Fever, cold tremor, leukemia or leukemia, acidic leukemia, joint pain and vasculitis.

Very rare peripheral neuritis, hair loss, nausea, vomiting, abdominal pain, diarrhea, headache, drowsiness and dizziness.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sadapron 300 mg remedica 3x10 contraindicated in the following cases:

Patients who know hypersensitivity to the active ingredient or excipients of the drug.

Exacentality of gout.

Be cautious when using

Treatment should stop immediately if any skin reaction or other signs of sensitivity. Do not reuse drugs in patients who are sensitive to the drug.

Monitor regularly liver, kidney and blood function. Reduce the dose in patients with liver or renal failure. Note that patients who are treating hypertension, heart failure or diabetes, elderly people and can also fail.

To reduce the risk of xanthin deposits in the kidneys, make sure to drink 2-3 liters a day. If during treatment you experience severe gout, continue to treat Sadapron 300 mg Remedica 3x10 and should use additional anti -inflammatory or colchicin drugs for at least a month.

Effect of kidney stones: Complete treatment with Sadapron 300 mg Remedica 3x10 will dissolve a large block of kidney stones that can affect the urine pipe.

If you do not tolerate some types of sugar, notify your doctor before taking this medication.

The ability to drive and operate machinery

Despite having adverse effects such as drowsiness, dizziness and loss in patients using Sadapron 300 mg Remedica 3x10, patients may still perform work with caution while driving, operating machine or participating in dangerous operations until Sadapron 300 mg remedica 3x10 their energy.

Pregnancy

There is no toxic effect on the fetus. Only used when indicated clearly.

Breastfeeding period

Allopurinol is excreted through human milk. Use carefully when breastfeeding.

Medicinal interaction

Many drugs interact with Sadapron 300 mg Remedica 3x10 and should not be used simultaneously. However, some can be used simultaneously with special caution. In this case, your doctor may change the dose or apply preventive measures. If you are about to use Sadapron 300 mg Remedica 3x10, you should notify your doctor or pharmacist you are taking other drugs and especially the following drugs: Mercaptopurin, Azathioprin, Vidarabin, Salicylate, Uric acid increase drugs, chlorpropramid, anticoagulants, phenytoin Cyclosphosphamide, doxorubicin, processbazin, mechloroethamine, cyclosporin, bheomycin.

Storage

Store at room temperature, avoid moisture, avoid light. Do not store in the bathroom. No storage in the freezer. Each drug may have different storage methods. Read carefully storage instructions on the packaging, or ask the pharmacist. Keep pills out of reach of children and pets.

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