Safaria Farmaprim vaginal gauge treats mixed infections in the vagina (2 blisters x 5 tablets)

Dosage form Box of 2 blisters x 5 tablets
Specifications Metronidazole, chloramphenicol, nystatin

Ingredient

Composition information	Content
Metronidazole	225mg
Chloramphenicol	100mg
Nystatin	75mg

Uses

indications

Safaria 400 mg is indicated in the following cases:

Treatment of mixed infections in the vagina, vaginitis with white blood, itching caused by bacterial and fungal, vaginitis caused by trichomonas. Vaginitis due to many different causes.

This effect is due to the combination of:

metronidazole

Metronidazole is a substance with a wide bacterial activity on the protozoa such as amoeba, Giardia Lambia and in anaerobic bacteria. Metronidazole has bactericidal effects on bacteroides, fusobacterium and other compulsory anaerobic bacteria but does not work on noni bacteria. Metronidazole is only resistant to a few cases.

However, when using Metronidazole alone to treat Campylobacter, Helicobacter pylori, the drug resistance is growing too fast. When infected with both aerobic and anaerobic bacteria, Metronidazole must be combined with other antibacterial drugs.

Trichomonas vaginalis infection can be treated with Metronidazole or localized. Both women and men must be treated, because men can carry pathogens without symptoms. In many cases, it is necessary to treat vaginal drugs and tablets.

When bacterial/vaginal inflammation is caused by bacterial/vaginal infections, Metronidazole will make the vaginal bacteria return to normal. In the vast majority of patients taking medicine, Metronidazole does not affect the normal vaginal bacteria.

chloramphenicol

Chloramphenicol is antibiotic, originally isolated from the Venezuelae Streptomyces, which is now produced by synthetic methods. Chloramphenicol usually has bactericidal effects, but can kill bacteria at high concentrations or for highly sensitive bacteria.

chloramphenicol inhibits protein synthesis in sensitive bacteria by attaching to the mini of the ribosom 50s. The drug has the same location with erythromycin, clindamycin, lincomycin, oleandomycin and troleandomycin.

Chloramphenicol also inhibits protein synthesis in rapid proliferation cells of mammals; Chloramphenicol may cause bone marrow inhibition and may not recover. Chloramphenicol has immunosuppressive activity if the whole body is used before the antigen stimulates the body. However, antibodies may not be significantly affected when using chloramphenicol after antigen.

Many bacteria have high drug resistance with chloramphenicol in Vietnam; This drug has almost no effect on Escherichia Coli, Shigella Flexneri, Entobacter spp. Chloramphenicol has no effect on mushrooms.

In general, chloramphenicol inhibits in vitro sensitive bacteria at a concentration of 0.1 - 20 micrograms/ml.

Drug resistance:

The anti -drug ratio for chloramphenicol, In vitro testing in Vietnam in 1998: Shigella Flexneri (85%), Escherichia Coli (83%), Entobacter spp. (80%), Staphylococcus aureus (64%), Salmonella Typhi (81%), Streptococcus Pneumoniae (42%), Streptococcus Pyogenes (36%), Haemophilus Influenzae (28%).

In vitro test shows that the drug resistance for chloramphenicol gradually increases gradually. This resistance is due to excessive use and is spread through plasmid. Anti -drug for some other antibacterial drugs, such as aminoglycosides, sulfonamid, tetracyclin, can also be spread on the same plasmid.

nystatin

Nystatin is an anti -fungal antibiotic extracted from streptomyces noursei mushroom culture, yellow powder, very little soluble in water. Nystatin has the effect of restraining or killing fungi depending on the concentration and sensitivity of the fungus, not affecting the normal limb bacteria on the body. The most sensitive is the yeast and has a very good effect on Candida Albicans.

Mechanism of action:

Due to the associated with the sterol of the cell membrane sensitive fungi, nystatin changes the permeability of the mushroom membrane. Nystatin tolerates well even when long -term treatment and does not cause drug resistance.

Dynamic pharmacokinetics

metronidazole

Put a single dose of 5 g of vaginal gel (equal to 37.5mg of metronidazole), the average serum metronidazole concentration is 237 nanogam/ml. This concentration is about 2% of Metronidazole concentration maximum moderate in serum after drinking once 500 mg of metronidazole (average CMAX is 12,785 nanogam/ml). These peak concentrations reached 6 - 12 hours after using the gel in the vagina.

nystatin

Do not absorb through the skin or mucosa when used on the spot, excreted mainly in the fertilizer in the form of unprocessed.

Before taking Safaria Farmaprim vaginal gauge treats mixed infections in the vagina (2 blisters x 5 tablets)

How to use

use vagina.

Before placing, put the pill in the freezer compartment for 5-10 minutes, wash the vagina, put deep into the vagina every night before going to bed.

To get the best treatment results, use your fingers to push the pills as deep as the vagina as possible.

Dosage

Adults

With acute vaginitis: 1 tablet each time, 1-2 times a day (morning and evening). Then maintain 1 tablet in the evening within 6 - 8 days. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

When using an overdose, leukopenia and peripheral sensory neuropathy, recovery when stopping treatment. Nausea, vomiting, diarrhea , dyeing urine (dark due to metronidazole overdose).

Handling

Overdose treatment: Stop medication and symptomatic treatment.

Side Effects

Local reactions (> 1%) include minor burns, irritation, vaginal irritation, vaginal itching. Especially when there is an open damage. Itching especially when starting treatment, but no treatment.

Allergic reactions include rash.

If the symptoms are mild, unclear, there is no need to stop the drug.

Notify the doctor the side effects occur when taking the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Safaria 400 mg Contraindicated for cases of sensitivity to one of the ingredients of the drug: History of hypersensitivity to metronidazol or other nitro-imidazol conductors, hypersensitivity to nystatin, patients with hypersensitivity and toxic reactions caused by chloramphenicol.

Be cautious when using

avoid sex during treatment. To prevent re -infection, it is necessary to treat your partner simultaneously.

Must treat the drug enough time despite symptoms. After 4 weeks of treatment, if not supported again.

Avoid sources of infection or re -infection.

may reduce the reliability of mechanical contraception measures ( condoms , vaginal diaphragm) due to the interaction of bullets and rubber membranes.

Be cautious when used for people with severe liver dysfunction.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Cloramphenicol does not have enough research data on pregnant people for the first 3 months. Only used for pregnant women in the first 3 months when the doctor is clearly indicated.

Metronidazole through the placenta is quite fast, achieving a proportion of concentrations between the stem of the placenta and the mother's plasma is approximately 1. Although thousands of pregnant women have taken the drug, there has not been notice of teratogenic causing. However, there are also a number of studies that have announced the risk of monsters increasing when taking the drug in the first 3 months of pregnancy. Therefore, it should not be used in the first time during pregnancy, unless required.

Nystatin has no risk of notice.

Breastfeeding period

Cloramphenicol still does not know whether the drug is excreted through milk, cautious when used for nursing mothers.

Nystatin does not excrete on breast milk.

Metronidazole is excreted in the breast milk quite quickly, breastfed babies may have a plasma medication concentration of about 15% of the mother concentration. Should stop breastfeeding with Metronidazole.

Drug interactions

Sperm kills: Do not coordinate (the risk of disabling the trichomonas killers on the spot contraceptive effect of spermicide).

Do not coordinate with alcohol, disulfiram (causing acute paranoia, and mental).

Metronidazole increases anticoagulant oral effects, especially warfarin, so avoid use at the same time.

metronidazole has a disulfiram -style effect. So do not use these two drugs simultaneously to avoid nervous effects such as psychosis, confusion.

Simultaneous use of metronidazole and phenobarbital increases metronidazole metabolism so Metronidazole is faster. Use Metronidazole for patients with high blood lithium concentrations (because they are using lithium) will increase the concentration of lithium lithium increased, toxic.

metronidazole increases the effect of vecuronium is a non -reducing muscle relaxant.

Storage

Store in closed packaging, avoid light, temperature below 30⁰C.

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