Safola Avisure treat anemia, iron deficiency during pregnancy (2 blisters x 15 tablets)

Dosage form Capsule
Specifications Box of 2 blisters x 15 tablets
Ingredient Fe (III), folic acid

Ingredient

Composition informationContent
Fe (III)166.67mg
Folic acid0.35mg

Uses

indications

Sfoli drugs are indicated in the following cases: To prevent and treat folic iron and folic acid during pregnancy when the supplement is not enough in the last 2 quarters of pregnancy (or from the 4th month). The drug is only used for pregnant women.

Pharmacokic

iron (III) Hydroxyd Poly Maltose (IPC)

iron is a component of hemoglobin molecule. IPC is composed of many polymaltose molecules surrounding the iron core (III) hydroxyd by linking the same structure as Ferritin - a iron iron plan of the body so IPC has a large molecular weight of about 52300 Dalton its diffusion through the mucosal membrane less than iron salt (II) about 40 times. When at high doses, iron exists in ionic state that easily causes harmful side effects such as intestinal disorders, iron poisoning, enamel color variables.

IPC is different from iron form (II) sulfate thanks to its safety and low toxicity due to no free iron ions. IPC ionized ionization of the IPC reduces the stomach irritation, helping patients tolerate better when treating iron deficiency anemia symptoms for a long time. The effectiveness of IPC in preventing and treating iron deficiency anemia has been proven in clinical trials. Hemoglobin value increases faster when using IPC compared to conventional iron salts. When using IPC, the hemoglobin value increased to 0.8 mg/dL per week. In addition, there is a faster increase than hematocrit, average cell mass, serum iron and ferritin.

Folic acid

Folic acid is group B vitamins B in the body of folic acid is reduced to tetrahydro folat is the coenzyme of many metabolic processes including synthesis of nucleotides with Purin or Pyrimidine nuclei; Therefore, it affects the synthesis of DNA. Folic acid also participates in some amino acid transformations. Folic acid is an indispensable factor for nucleoprotein synthesis and normal red blood cells. Folic acid deficiency causes huge red blood cell anemia like anemia due to vitamin B12 deficiency.

pharmacokinetics

iron (III) Hydroxyd Poly maltose (IPC)

The absorption of iron (III) from iron (III) Hydroxyd Polymaltose is a physiological process.

When the IPC complex is exposed to the positions associated with iron on the mucosal surface, it releases iron ions (III) and is actively transported into the mucosal cell thanks to a carrier protein and then linked to Ferritin or Transferrin. The carrier proteins include mucin, integrin and mobilferrin. Iron is released from carrier proteins and is stored in mucosal cells in the form of ferritin or carried by the carrier proteins and there is released to combine with transferrin.

Birth of IPC when taken is not affected by food ingredients such as phytic acid, oxalic acid, tannin, sodium alginate, cholin salt, vitamin A, D3, E, soybean oil and flour. The iron in the IPC complex enters the serum thanks to endogenous proteins, with a selling time of about 90 minutes, then entering the liver's endothelium or combined with transferrin, apoferritin, bone marrow or spleen to create red blood cells.

When iron passes through the intestinal velvet fence, it is associated with the transferrin, each transferrin molecule can be attached to two iron atoms. Normally about 20 - 45% of the locations are cohesive. The specific receptors of the cell membrane recognize the transferrin, allowing this complex to enter the cell and release iron into the cytoplasm.

iron in regular iron preparations, iron II ions, will easily irritate the stomach. The absorption of iron ions II is passive and uncontrolled, which can cause excess iron and toxic to the body. IPC has little pharmacokinetic interactions with other substances such as conventional iron salts.

Folic acid

Folic acid in nature exists in the form of polyglutamat into the body hydrolyzed by carboxypeptidase, reduced by DHF Reductase in the intestinal mucosa and Melyl chemicals to create mdihf, this substance is absorbed into the bloodstream. The drug is quickly distributed into the tissues in the body, cerebrospinal fluid, placenta and breast milk. The drug is accumulated mainly in the liver and in cerebrospinal fluid. After that, folic acid is eliminated by urine.

Before taking Safola Avisure treat anemia, iron deficiency during pregnancy (2 blisters x 15 tablets)

How to use

Sfoli is an oral medication. Swallow the tablet. Do not smoke, chew, take the pill in the mouth, take medicine with a large cup of water. Drink before meals or during meals.

Dosage

1 tablet/day during the last 2 quarters of pregnancy (or from the 4th month).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? The overdose symptoms include: irritating signs, gastrointestinal necrosis of the gastrointestinal pain, vomiting, bleeding diarrhea, accompanied by shock due to acute renal failure, impaired liver function, convulsions, coma.

Overdose treatment should be started as soon as possible by performing a stomach with 1%sodium bicarbonate solution.

Depending on the concentration of iron in the blood, the use of an artificial agent may be recommended, namely deferoxamin. If necessary, please refer to the product information of this drug.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

related to iron

Classification by organ system

Common

Less

Unknown frequency (not estimated from existing data)

immune system

Respiratory system

Constipation, diarrhea, bloating, abdominal pain, pale stool, nausea.

Abnormal reaction, indigestion, vomiting, gastritis.

Dental discoloration, mouth ulcers, gastrointestinal infections.

Elderly patients and patients have problems in swallowing may be damaged or bronchial necrosis if they use the drug improperly.

Related to folic acid

Classification by organ system

Unknown frequency (not estimated from existing data)

immune system

Anaphylactic reaction.

Gastrointestinal disorders.

Evaluation, atopic dermatitis, urticaria.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Iron overload, especially in cases of anemia such as Thalassemia, persistent anemia, anemia due to myelosuppression.

Hypersensitivity to any ingredient of the drug.

Be cautious when used

Reduce iron concentration in blood is associated with an iron -sensitive inflammatory syndrome. Iron supplements should be combined with treatment of causes within possible range.

Due to the risk of mouth ulcer and tooth color change, do not chew, suck, suck the whole pill in the mouth, but should take whole pills with water.

According to the literature, the formation of dark brown pigment in the gastrointestinal mucosa has been observed in some patients with iron supplements. These pigments can affect the process of digestive surgery. Therefore, this risk should be warned with a doctor if surgery during iron supplementation.

Using a large amount of tea can inhibit the absorption of iron.

The ability to drive and operate machinery

has not recorded the adverse reaction report on the effect of the drug on the ability to drive and control machinery.

Pregnancy

iron supplements are known to be safe and beneficial for both mother and child.

Lactation period

The ability to pass through the breast milk of iron salt has not been evaluated. However, due to its nature in the form of molecules, this drug can be used in nursing women.

Drug interaction

related to iron

Uncountable coordination:

  • iron (salt forms) injecting: fainting or shock due to rapid release of iron from complex form and transferrin saturation.

    • Coordination should be considered:

  • Acetohydroxamic acid: Reducing the absorption of both drugs due to chelate complex formation with iron ion.

    • Collaborate in need of kidneys during use:

  • Biphosphonats: Reduce the absorption of biphosphonate when used with oral iron salts. Use iron salts away from time to use biphosphonate (from at least 30 minutes to over 2 hours, if possible, depending on each type of biphosphonate).

    • Calcium: Reduce the absorption of oral iron salts. Use iron salts away from meals and do not use calcium.

    Cyclin (oral): Reduce the absorption of oral cyclins (due to complex formation). Use iron salts away from the time to use cyclins (over 2 hours if possible). Entacapon: Reducing Entacapon absorption due to the chelate formation between two substances. Use salts away from the time to use Entacapon (over 2 hours, if possible).

    Fluoroquinolon antibiotics, thyroid hormones, levodopa/carbidopa, penicillamin, zinc: reduce the absorption of these drugs. Use iron salts away from the time to use these drugs (over 2 hours, if possible).

  • methyldopa: reducing methyldopa absorption (due to complex formation). Use iron salts away from methyldopa (over 2 hours, if possible).

    • Salt, oxyd and hydroxid forms of magnesium, aluminum and calcium (used on the gastrointestinal tract): reduce the absorption of iron salts. Use iron salts away from the time to use these drugs (over 2 hours, if possible).

  • Cholestyramin: Reduce the absorption of iron salts. Use iron salts away from the time to use cholestyramin (1-2 hours before or after 4 hours).

    • Related to folic acid

    Phenobarbital, Primidon, Phenytoin, Fosphenytoin: Reduce the plasma concentration of anti -convulsions due to increased metabolism of these drugs through the liver, in which folic acid is a combined substrate. Clinically monitored and monitor the concentration of anti -convulsions in plasma and calibration of these drugs if necessary, during the time the folic acid coach and after the drug stopped.

    Storage

    Put in a dry place, avoid light, temperature below 30⁰C.

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