Samarin 140 Paradigm treatment for hepatitis, cirrhosis, alcoholic liver disease, liver damage (10 blisters x 10 tablets)

Thanks to the phenolic structure, flavonoids (including silymarin) have very good antioxidant activity. In addition, it also has the ability to stabilize cell membranes.

Silymarin neutralizes free radicals and has antioxidant activity. This is considered the main mechanism to explain the liver protection effect of Silymarin. Silymarin protects the liver by changing the liver cell membrane to reduce the penetration of toxins into the liver cells and lock the positions combined with the poison. Silymarin affects cell membranes, prevents the penetration of toxins into cells such as amanitin and phalloidin as well as the loss of cell components (transaminase, potassium) to the outside environment. The stability of cell membrane is supported by the anti -peroxidization of silymarin related to the neutralization of free radicals. Since then, the peroxid cycle lipid causes interrupted cell membrane damage.

Silymarin increases intracellular glutathion levels, which is essential in detoxification systems in liver cells.

Silymarin inhibits the lipid peroxidization process of liver cells, microsom and red blood cells; At the same time increases protein synthesis through stimulating ribosom RNA and increases the regeneration ability of liver cells. Moreover, Silymarin increases the synthesis of ribosom RNA by stimulating the activity of RNA enzyme-polymerase I in the nucleus.

The number of ribosom increases as genetic information is decoded with higher frequency.

This leads to an increase in biosynthesis of functional substances (enzymes). Clinical Silymarin treatment effects are reflected by reducing the concentration of liver enzymes in the rod and normalizing plasma proteins.

Silymarin also has anti -inflammatory properties due to inhibition of Leukotrien synthesis. This anti -inflammatory effect is useful in the treatment of cirrhosis.

Silymarin is used in the treatment of many liver diseases such as functional failure and degenerative necrosis. Clinical trials recorded Silymarin capable of improving liver function.

pharmacokinetics

Silymarin insoluble in water, poor absorption through the gastrointestinal tract. In humans, the absorption rate from the intestine, based on the excretion of the kidneys and biliary tract, is about 20-40% when using Samarin 140 mg only dose. The rapid absorption at the time is most excreted in the tester from 2 - 4 hours. After repeated doses of treatment (Samarin 140 mg x 3 times/day), the concentration of Silibinin in the bile recorded unchanged compared to the case of a single dose. This shows that Silibinin is not accumulated in the body.

The peak concentration of plasma is achieved within 4 - 6 hours.

Silymarin is excreted mainly through bile (-80% of absorption) and less in urine.

Selling time is about 6 - 8 hours. Silymarin and other Silymarin compounds combine quickly with sulphat and glucorunic in the liver. These forms of coordination will be transferred to plasma and bile, about 80% of the total dose. The metabolites found in the face are sulphate and glucorunie.

Caution when using

Read the instructions carefully before use. For more information, please consult a doctor.

Silymarin inhibits Cytochrom P450 2C9 and Cytochrom P450 3A4; In human studies show that Silymarin does not affect the pharmacokinetics of Indinavir. Silymarin can reduce blood sugar in patients with cirrhosis and diabetes.

The effect of the drug on driving and operating machinery

No data.

Using drugs for women during pregnancy and lactation

Scientific evidence of safety when used for pregnant and lactating women is still not available, not recommended for pregnant and lactating women.

Drug interaction

Metronidazol: Using combination of Metronidazol and Silymarin, significantly increases the elimination of Metronidazol and significantly reduces the contact with Metronidazol. In case of necessity to use, Metronidazol should be increased.