Sanaperol medicine for treatment of thick reflux disease, esophagus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rabeprazole

Ingredient

Composition information	Content
Rabeprazole	20mg

Uses

Indications

Sanaperol 20 drugs are indicated in the following cases:

Treatment gastroesophageal reflux disease (GERD) causes ulcers or corrosion. Trang . Proton Benzimidazole instead) does not manifest the antagonist properties H2 H2 or acetylcholine secretion, but prevents gastric secretion by inhibiting H+/K+-Aatpase on the surface of the secretion of the stomach cells. Because this enzyme is considered as an acid pump (proton) in the wall of the wall, Rabeprazole is characterized as a stomach proton pump inhibitor. Rabeprazole prevents the final stage of gastric secretion. In stomach wall cells, Rabeprazole receives an additional proton, accumulated and transformed into an active sulfenamide.

pharmacokinetic

absorption

The absolute biological comfort of the Rabeprazole tablet tablets orally 20 mg (compared to the intravenous use) is approximately 52%. When Rabeprazole is used with a high -fat meal, TMAX is changed and can slow down the absorption for up to 4 hours or longer, but CMAX and Rabeprazole's absorption level (AUC) change are negligible. Therefore, Rabeprazole can be used without caring for meal time.

Distribution

rabeprazole binding to plasma proteins is 96.3%.

Metabolism

Rabeprazole is strongly metabolized. Thioether and sulphone are the main metabolites found in human plasma. These metabolites have no significant antagonism activity. In vitro studies prove that Rabeprazole is metabolized in the liver mainly by Cytochrome P450 3A (CYP3A) into Sulphone and Cytochrome P450 2C19 (CYP2C19) to Reducing Methyl.

Elimination

After taking a single dose of 20 mg of Rabeprazole, there is a 14C radioactive isotope, about 90% of the drug is discharged into the urine, mainly Thiioether carboxylic acid; Its glucuronide and mercapturic acid metabolites. The rest is found in stool. The total radioactive activity found is 99.8%. Rabeprazole is not found in urine or in feces.

Before taking Sanaperol medicine for treatment of thick reflux disease, esophagus (3 blisters x 10 tablets)

How to use

Rabeprazole tablets should be swallowed whole. Do not chew, crush or break the pill. Rabeprazole tablets can be used with or not accompanied by food.

Dosage

Treatment of gastroesophageal reflux disease (GERD) causes ulcers or corrosion

The dosage for adults recommends 20 mg Rabeprazole, drink once a day about 4 to 8 weeks. For patients who do not help after 8 weeks of treatment, one more treatment can be used with Rabeprazole 8 more weeks.

Maintain after healing gastroesophageal reflux disease (GERD) causes ulcers or corrosion

The dosage for adults recommends 20 mg Rabeprazole, drink once daily.

Treatment of gastroesophageal reflux disease (GERD) symptoms

The dosage for adults recommends 20 mg Rabeprazole, drink once a day about 4 weeks. If the symptoms are not completely resolved after 4 weeks, one more treatment may be used.

Treatment of duodenal ulcer

The recommended adult oral dose is 20 mg Rabeprazole, drink once a day after breakfast with a treatment of about 4 weeks. The majority of patients heal duodenum ulcers within 4 weeks. Some patients may need one more treatment to heal the ulcer.

Combining antibiotics to treat peptic ulcer by HP

Three drug therapy:

rabeprazole: 20 mg twice daily x 7 days.

Amoxicillin: 1000 mg twice daily x 7 days.

Rabeprazole dose for patients with increased diseases that varies from individuals. The starting dose for adults recommends 60 mg once a day. The dose should be adjusted according to the needs of each patient and prolonged use according to clinical indications. Some patients may need to divide the dose. The dose can be used up to 100 mg once daily and 60 mg twice daily.

It is not necessary to adjust the dose for the elderly, patients with kidney disease or mild to medium liver failure patients. Due to the lack of clinical data of Rabeprazole in patients with severe liver failure, it is cautious when taking the drug for these patients.

Rabeprazole is recommended not for children, because there is no experience used in children.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? There is no specific antidote for Rabeprazole. Rabeprazole is strongly linked to protein and is not easily separated. In case of overdose, symptomatic treatment and support.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Sanaperol 20 , you may experience unwanted effects (ADR).

In the short -term and long -term studies, the following side effects, regardless of the cause, have been reported in patients treated with Rabeprazole.

Body: weakness, fever, allergic reactions, chills, discomfort, chest pain under the breastbone, stiff neck, light sensitive reaction. Dry mouth, belching, gastritis, rectal hemorrhage, black bowel movement, anorexia, mouth ulcers, stomatitis, difficulty swallowing, gingivitis, cholecystitis, increased appetite, colonitis, esophagitis, tongitis, pancreatitis , rectal inflammation. Blood. tremor. middle. Hemorrhage, hypoglycet, leukemia, abnormal liver function tests, increased SGPT, abnormal urine. There are no clinical significant tests due to drug combination.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sanaperol 20 drugs contraindicated in the following cases:

Patients who know how to be hypersensitively to Rabeprazole, benzimidazole instead or any ingredients of the drug.

Precautions when using

responding to symptoms when treating with Rabeprazole does not rule out the presence of malignant stomach tumors. The interaction in Rabeprazole's stability with Warfarin has not been evaluated in patients. There have been several reports on Inr and prothrombin increase in patients treated and proton pump inhibitors with warfarin. Inranger and prothrombin time can lead to abnormal bleeding and even death.

patients treated at the same time inhibit the proton pump with warfarin, they need to monitor the increase in the Inr and the prothrombin time.

The ability to drive and operate machinery

The drug can cause drowsiness, dizziness so cautious when driving and operating machinery.

Pregnancy

There are no good and suitable studies for pregnant women. Because studies on animal reproduction do not always predict the response to humans, so it should only be used during pregnancy if really necessary.

Breastfeeding period

Due to many drugs excreted in milk, and due to the possibility of side effects on infant breastfeeding from Rabeprazole, deciding to stop the drug or stop breastfeeding, taking into account the importance of the drug for the mother.

Drug interaction

Rabeprazole is metabolized by P450 (CYP450). Studies to healthy people think that Rabeprazole does not have a clinical significant interaction with other drugs metabolized by the CYP450 system, such as Warfarin and Theophylline using single doses, diazepam doses of single -dose injection and phenytoin used single -dose injection (several doses of supplements).

Interaction in Rabeprazole's stability with other drugs metabolized by this enzyme has not been studied to patients. There have been several reports on Inr and Prothrombin increase in patients treated and inhibit the proton pump inhibitors, including Rabeprazole with warfarin . Inranger and prothrombin time can lead to abnormal bleeding and even death.

Rabeprazole inhibits continuous gastric secretion may occur in interaction with substances where the absorption of the drug depends on the stomach pH due to the acid -secreting intensity of Rabeprazole. For example, in normal people, simultaneously rabeprazole 20 mg once a day reduces approximately 30% of the bioavailability of ketoconazole and increases the AUC and CMAX of Digoxin, respectively 19% and 29% respectively. Therefore, it is necessary to monitor patients when such drugs are used simultaneously with Rabeprazole.

Treatment of combination of three rabeprazole, amoxicillin and clarithromycin drugs increases the plasma concentrations of rabeprazole and 14-hydroxyclarithromycin.

Storage

Store in a cool, dry place, below 30 ° C, avoid light.

To be out of reach of children.

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