SANCEFUR 35mg Pharmathen medicine for osteoporosis and prevention (1 blister x 4 tablets)

Dosage form Box of 1 blister x 4 tablets
Specifications RisesDronate

Ingredient

Composition information	Content
RisesDronate	35mg

Uses

indications

SANCEFUR drugs are indicated in the following cases:

Treat osteoporosis in postmenopausal women. Hydroxyapatite in the bone and acts as an anti -bone destruction agent. The bone movement is reduced while creating cells and soaked in minerals is protected. In clinical research Riseadronate sodium has anti -cell cancellation effects. The impact of sodium RISDRONAT is determined by measuring the biochemical indicators of Chu Chuyen Bone during the pharmacological and clinical research period.

In the study in postmenopausal women, it is found to reduce biochemical indicators in the bone transfer within 1 month and reach the maximum of 3-6 months. Reducing biochemical indicators in bone transfer is similar to 35 mg/week and Riseadonate 5 mg/day/day for 12 months. In the study in the South, there was an osteoporosis, a decrease in bone movement at the earliest time of 3 months and continued to see at the time of 24 months.

Pharmacokinetics

absorption

The drug is absorbed quickly after taking a dose (TMAX about 1 hour) and independent of the dose in the research range (the only dose is from 2.5 mg to 30 mg, multiple doses of 2.5 to 5 mg/day and up to 50 mg/week). Oral bioavailability is 0.63% and reduces when using sodium Riseadronate along with food. Born in men and women similarly.

Distribution

The average distribution volume is 6.3 /kg. The ratio of cohesion to plasma protein is 24%.

Metabolism

There is no evidence of systemic metabolism of sodium Riseadronate.

Elimination

About half of the absorption dose is excreted through urine for 24 hours. The average renal clearance is 105 ml/min and the average total clearance is 122 ml/min, the difference of clearance can be attributed to the absorption of the bone. The renal removal does not depend on the concentration and linear between the renal and the clearinine clearance. Sodium Riseadronate does not absorb excretion in a constant form.

Before taking SANCEFUR 35mg Pharmathen medicine for osteoporosis and prevention (1 blister x 4 tablets)

How to use

should take medicine on a certain day of the week. The absorption of sodium Riseadronate is affected by food and drinks. Therefore, do not take this medicine with food and other drugs or drinks (except for water).

Take a tablet at least 30 minutes before eating (except for water) or take a different medicine for the first time of the day.

If you forget to take a dose of sodium 35 mg, you should take one piece immediately in the morning after remembering and then take one tablet a week on a certain day chosen from the beginning. Never take two capsules in the same day.

Should swallow the pills, do not suck or chew. To make the drug easy to reach the stomach, it is advisable to take Riseadronat in a vertical position with a regular glass of water (> 120 ml). Patients should not lie within 30 minutes after taking the drug. Calcium and vitamin D should be supplemented if the diet is not complete.

Dosage

Dosage for adults is 35 mg per week.

Old people:

No need to adjust the dose due to biological use, distribution and elimination in people over 60 years old is similar to young people.

Patients with renal failure:

No dose adjustment in patients with mild to medium renal failure. Do not use drugs for patients with severe renal impairment (clearly less than 30 ml/minute).

Children:

Safety and effectiveness of RISDEDRONAT 35 mg has not been proven in children and teenagers.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? After serious overdose can see a losing serum calcium. Signs and symptoms of blood calcium can also occur in this patient. Take milk or antacids containing magnesi, calcium or aluminum to attach to riseadronate and reduce the absorption of sodium riseadronate.

In case of severe overdose, the stomach may be required to eliminate the absorption cure.

What to do when forgetting a dose? Never take two capsules in the same day.

Side Effects

When using SANCEFUR, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neurology: headache.

Digestive: constipation, indigestion, vomiting, abdominal pain, diarrhea.

Osteoarthritis: Muscle pain

Uncommon, 1/1000

Eyes: irisitis.

Gastrointestinal: gastritis, esophagitis, difficulty swallowing, duodenitis, esophageal ulcer.

Rare, ADR

digestive: tongue inflammation, esophageal stenosis.

Not determined frequency

Whether there is an abnormal liver function test report.

Calcium and serum phosphate concentrations on some patients are noticed slightly, occurring early, transient and asymptomatic.

Instructions on how to handle ADR

Side reactions are usually mild to moderate and do not need to stop taking the drug.

Notice an unwanted effect when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SANCEFUR drugs in the following cases:

Patients with allergies to sodium Riseadronate and the ingredients of the drug.

Hypercalcemia.

Pregnant and lactating women.

Severe renal failure (Creatinine clearance

Caution when using

Food and drink (except for normal water) and products containing calcium, magnesium, iron or aluminum can hinder the absorption of bisphosphonate and not used at the same time as when taking medicine.

The effect of treating osteoporosis of bisphosphonate is related to low bone mineral density and/or fracture.

bisphosphonate is related to esophagitis, gastritis, esophagitis and stomach ulcers. So be cautious for:

Patients with a history of esophageal disorders that slow transportation or emptiness such as narrowing or losing the ability to expand.

Statement for patients should emphasize the importance of adhering to the drug tutorial for this patient and alert with any signs and symptoms of the esophagus. Patients should be instructed to treat promptly if there are symptoms of esophageal irritation such as: difficulty swallowing, swallowing pain, or heartburn.

It is recommended to treat blood calcium before starting treatment with rISEDRONAT. Other disorders of bone metabolism and minerals (such as thyroid dysfunction, vitamin D deficiency) need to be treated when starting to use Riseadronat.

Because the drug contains lactose, patients have a problem with galactose intolerance, lactase deficiency or galactose abutment should not be used.

The ability to drive and operate machinery

Precautions when used because RISDEDRONAT has side effects such as headache, musculoskeletal.

Pregnancy

There is no adequate data for the use of sodium Riseadronate for pregnant women. Animal studies have seen reproductive toxicity. Therefore, sodium Riseadronate is not used for pregnant women.

Breastfeeding period

Animal research shows a small amount of sodium riseadronate passing through breast milk. Therefore, sodium Riseadronate is not used for breastfeeding women.

Drug interaction

no official interactive studies have been conducted, however, in clinical studies, there is no clinical interaction with other drugs.

If appropriate, simultaneously can be used with sodium Riseadronate with estrogen supplementation.

Concomitance medications containing calcium, magnesium, iron and aluminum can hinder the absorption of riseadronat.

Riseadronate sodium is not metabolized, does not cause P450 enzyme and is less attached to protein.

Storage

In a cool dry place, avoid light and moist. Below 30 ° C.

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