Sara 500mg Nakorn medicine helps reduce fever pain (25 blisters x 4 tablets)

Dosage form Box of 25 blisters x 4 tablets
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

indications

SARA 500 mg drug is indicated in the following cases:

Treatment of pain and fever from mild to medium.

Pain relief in cases: headache, migraine, dysmenorrhea, muscle pain, sore throat, toothache, pain due to colds or flu, fever or pain after vaccination, pain after tooth extraction or after dental procedures. An effective analgesic - antipyretic can replace aspirin; However, unlike aspirin, paracetamol is not effective in treating inflammation. With equal dose in grams, paracetamol has analgesic and antipyretic effects similar to Aspirin.

paracetamol reduces body temperature in fever but rarely reduces body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid-base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on the body cycloxygenase, only affect cycloxygenase/prostaglandin of central nervous system. Paracetamol does not work on platelets or bleeding time.

pharmacokinetics

absorption:

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. The peak concentration of plasma is within 30 - 60 minutes after drinking with the dose of treatment.

Distribution:

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism:

Paracetamol is n-hydroxylation by cytochrom P 450 to create N-acetyl Benzoquinonimin, an intermediate reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and is dimidated.

Era:

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage.

Before taking Sara 500mg Nakorn medicine helps reduce fever pain (25 blisters x 4 tablets)

How to use

oral medication.

Dosage

Adults: Take each time from 1-2 tablets, 4 - 6 hours at a time, no more than 4 g/day.

Children from 6 -12 years old: Take each time from 1/2 -1 capsules, 4 -6 hours at a time, no more than 4 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? There are methods to quickly determine the concentration of drugs in plasma. However, do not delay treatment while waiting for the test results if the history is suggested to overdose. When severe poisoning, it is important to treat positive support. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver. N-acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with n-acetylcysteine is more effective when giving the drug for less than 10 hours after taking paracetamol.

Without N-Acetylcystein, methionine may be used. Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Sara 500 mg, you may experience unwanted effects (ADR).

Uncommon, 1/1000

DA: Ban.

stomach - intestines: nausea, vomiting. Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, 1/10000

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

SARA 500 mg drug contraindicated in the following cases:

Sensitive to paracetamol or any ingredient of the drug.

Patients with many anemia or heart disease.

Patients with glucose-6-phosphate dehydrogenase deficiency.

Be cautious when using

If a sensitive reaction occurs, it is necessary to stop taking the drug.

If the pain is severe or recur, high fever or fever continuously, the disease is serious. If the pain persists for more than 5 days, the redness of the joint is swollen or rheumatism in children younger than 12 years old, they must consult the physician immediately.

Use carefully with liver failure.

Serious side effects on the skin, although the incidence is not high but serious, even life-threatening including Steven-Johnson syndrome (SJS), Poisoned skin necrosis syndrome: Toxic Epidermal Necrolysis (Ten) or Lyell syndrome, acute external pustules syndrome: Acute Generalized Exanthematous Purulosis (AGEPSIS).

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had severe skin reactions caused by Paracetamol must not use the drug again and when they come to medical examination and treatment, they need to notify the medical staff on this issue.

The ability to drive and operate machinery

Sara does not affect the ability to drive, operate machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may have for fetal development. Therefore, only Paracetamol should only be used in pregnant people when really necessary.

The period of breastfeeding

Research in the mother using paracetamol breastfeeding, does not see unwanted effects in breastfed babies.

Drug interaction

Long -term oral high doses Paracetamol increases the anticoagulant effect of COUMARIN and derivatives.

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increased risk of toxicity to the liver. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous dosage to treat paracetamol and anti -convulsions, however, patients must limit the use of paracetamol themselves while taking anti -convulsions or isoniazid.

Alcohol: Excessive and long drinking can increase the risk of paracetamol toxic to the liver.

Activated carbon reduces the absorption of paracetamol.

Storage

Store in a dry place, no more than 30 ° C.

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