Sara 500mg Thai Nakorn Patana medicine for headaches, dysmenorrhea (20 blisters x 10 tablets)

Dosage form Box of 20 blisters x 10 tablets
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	500mg

Uses

Indications

SARA 500mg drug is indicated in the following cases:

Treatment of pain and fever from mild to medium. Learning

paracetamol is a substance that is active in phenacetin, an effective analgesic - antipyretic drug that can replace aspirin. However, unlike aspirin, paracetamol is not effective in treating inflammation. With equal dose in grams, paracetamol has analgesic and antipyretic effects similar to Aspirin.

paracetamol reduces body temperature in fever but rarely reduces body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

Paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not work on cycloxygenase, only affect cycloxygenase/prostaglandin of central nervous system. Paracetamol does not work on platelets or bleeding time.

When overdose of paracetamol, a metabolic substance is N-acetyl-benzoquinonimin that is toxic to the liver. Normal doses, paracetamol tolerated well, without many side effects of aspirin. However, an acute overdose (over 10g) damages liver and liver and poisoning and suicide with Paracetamol has increased worrying in recent years. In addition, many people including physicians seem to know the poor anti -inflammatory effects of Paracetamol.

pharmacokinetic

absorption

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract. The peak concentration of plasma is within 30 - 60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The half -life of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage. After the treatment dose, 90 - 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%).

also detects a small amount of hydroxylation and reduction of acetyl. Young children are less likely to be more in line with the drug than adults. Paracetamol is n-hydroxylation by cytochrom P450 to create N-acetyl Benzoquinonimin, an intermediate reaction.

This metabolite normally reacts with sulfhydryl groups in glutathion and is dedicated. However, if you take high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver, in that situation, its reaction to the sulfhydryl group of the liver protein increases, which can lead to liver necrosis.

Before taking Sara 500mg Thai Nakorn Patana medicine for headaches, dysmenorrhea (20 blisters x 10 tablets)

How to use

Sara 500mg Used orally.

Dosage

Adults

Take each time from 1-2 tablets, 4 - 6 hours at a time, no more than 4g/day.

Children from 6-12 years

Take each time from 1/2 - 1 tablet, 4 - 6 hours at a time, no more than 4 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose

Paracetamol poisoning may be due to a single -dose, or due to a large dose of paracetamol (e.g. 7.5 -10g per day, for 1-2 days) or for long -term medication. The liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be caused by death.

Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the poison of the drug. Methemoglobin - blood, leading to purple blue, mucous membranes and nails is a sign of acute poisoning P - Aminophenol, a small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitation and delusion. Next can be inhibiting the central nervous system, stunned, lower body heat, tired, fast breathing - shallow, fast circuit - weak - irregular, low blood pressure, circulatory failure. Vascular collapse can occur in huge doses. Shock may occur if a lot of vasodilation. The suffocating convulsions may occur. Coma occurs before you die suddenly or after a few days of coma.

In 2 - 4 days after taking toxic dose: there are signs of liver damage.

Handling

Early diagnosis is important in the treatment of paracetamol overdose. There are methods to quickly determine the concentration of drugs in plasma. However, do not delay treatment while waiting for the test results if the history is suggested to overdose. When severe poisoning, it is important to treat positive support. Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver. N-acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol. Treatment with n-acetylcysteine is more effective when giving the drug for less than 10 hours after taking paracetamol.

When drinking, dilute N-acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing. Give N-acetylcystein with the first dose of 140mg/kg, then give 17 more doses, each dose of 70mg/kg each 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

The unwanted effect of N-acetylcystein includes skin rash (including urticaria, no need to stop the drug), nausea, vomiting, diarrhea, and anaphylactic reaction. Without N-Acetylcystein, methionine can be used. Also can use activated carbon or saline, they have the ability to reduce the absorption of paracetamol.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. Sensitive diseases with rare salicylate sensitive to paracetamol and related drugs. In a few individual cases, Paracetamol has caused neutropenia, thrombocytopenia and all bloody hematoma.

Uncommon, 1/1000

Skin: Ban.

Other: Hypersensitivity reaction.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

sensitive to paracetamol or any ingredient of the drug.

Patients with anemia many or heart disease.

Be cautious when using

If a sensitive reaction occurs, it is necessary to stop taking the drug.

If the pain is severe or recur, high fever or fever continuously, the disease is serious. If the pain persists for more than 5 days, the redness of the joint is swollen or rheumatism in children younger than 12 years old, they must consult the physician immediately.

Use carefully with liver failure.

Serious side effects on the skin, although the incidence is not high but serious, even life-threatening includes Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome: Toxic Epidermal Necrolysis (Ten) or Lyell syndrome, acute overseas pustules syndrome: Acute Generalized Exanthematous Puplosis (AGEPSIS). Symptoms of the above syndrome are described as follows:

Steven-Johnson syndrome (SJS): is an allergy to puffiness, localized puffiness around natural cavities: eyes, nose, mouth, ears, genitals and anus. In addition, it may be accompanied by high fever, pneumonia, liver dysfunction. Diagnosis of Steven-Johnson syndrome (SJS) when there are at least 2 naturally damaged cavities. cornea. Acute body pus (AGEP): Small sterile pustules arise on the spreading platform. Damage often appears in folds such as armpits, groin and face, then can spread the whole body. Systemic symptoms are often fever, neutral salt blood leukemia test.

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug. People who have had severe skin reactions caused by Paracetamol must not use the drug again and when they come to medical examination and treatment, they need to notify the medical staff on this issue.

Doctors need to warn patients on signs of serious skin reactions such as Steven Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

Sara 500mg does not affect the ability to drive, operate machinery and people working on high.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to pregnancy development. Therefore, Paracetamol should only be used in pregnant women when really necessary.

Breastfeeding period

Research in mothers using paracetamol breastfeeding, not seeing unwanted effects in breastfeeding.

Medicine interaction

long -term oral doses of high doses Paracetamol increases the anticoagulant effect of COUMARIN and derivatives.

Need to pay attention to the likelihood of serious antipyretics in patients with phenothiazine and cooling therapy.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increased risk of toxicity to the liver.

The risk of paracetamol causes liver toxicity significantly increases in patients who take paracetamol dose larger than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions, but patients have to limit their own Paracetamol self -use while taking anti -convulsions or isoniazid.

Alcohol: Excessive and long drinking can increase the risk of paracetamol toxic to the liver.

Activated carbon reduces the absorption of paracetamol.

Storage

Store in a dry place, avoid moisture, temperature below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.