Sara for Children's chaos 120mg/5ml pregnancy Nakorn Patana - Strawberry incense - Antipator and pain relief (30ml)

Dosage form Bottle x 30ml
Specifications Acetaminophen

Ingredient

Composition information	Content
Acetaminophen	120mg

Uses

Indications

Sara Strawberry Children Nakorn 30 ml medicine is indicated in the following cases:

A reducing and analgesic treatment for children and babies.

Pharmacokology

Pain relief

The mechanism of analgesic effects has not been fully determined. Paracetamol can act by inhibiting the synthesis of prostaglandin in the central nervous system, and to a lower level, through peripheral effects by preventing pulse transmission of pain. The peripheral effect may also be due to prostaglandin synthesis or synthetic inhibition or the impact of substances that are sensitive to painful receptors to stimulate mechanical or chemicals.

A reduction of fever

Paracetamol causes an antipyerer by impacting the central thermostat in the hypothalamus, causing peripheral vasodilation, causing sweating and escaping heat. The main effect may be related to the ability to inhibit the synthesis of prostaglandin in the hypothalamus.

pharmacokinetic

absorption

Paracetamol absorbs quickly and almost entirely according to the gastrointestinal tract. The peak concentration in plasma appears after 0.5 to 2 hours, absorb faster when used in the form of solution. When used overdose, completely absorbed within 4 hours.

Metabolism and elimination

Paracetamol is metabolized and excreted mainly in urine in the form of inactive combination with glucuronic and sulfate acid (94%).

About 4% converted through the Cytocrom P450 oxidase system into a toxic substance then combined with glutathione in the liver and excreted through urine in the form of cysteine or mercapturic acid.

When using Paracetamol regularly or overdose, glutathione reserves will end and can cause liver necrosis.

There are 2 to 4% elimination in the form of unchanged, the average selling time from 1 to 3 hours. Prolonged half -life in infants (2.2 to 5 hours) and in cirrhosis patients.

Before taking Sara for Children's chaos 120mg/5ml pregnancy Nakorn Patana - Strawberry incense - Antipator and pain relief (30ml)

How to use

Sara Strawberry Children Nakorn 30 ml is used orally.

Dosage

Take every 4-6 hours when necessary but not more than 5 times/day.

Children 4 months - 1 year: ½ teaspoon (2.5 ml)/ time.

Children 1 - 2 years old: 1 teaspoon (5 ml)/ time.

Children 2 - 6 years old: 1 - 2 teaspoons (5 - 10 ml)/ time.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Expression:

Nausea, vomiting, abdominal pain, purple blue, mucous membranes, nails. The liver necrosis depends on the dose is the most serious toxic effect due to overdose. Liver damage becomes clearly within 2-4 days after taking toxic doses.

Overdose:

Stomach, drink or intravenously N-acetylcystein to detoxify paracetamol. Without n-acetylcystein, methionine, activated carbon and/or saltworm.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Sara Strawberry Children Nakorn 30 ml medicine, you can experience unwanted effects (ADR).

Uncommon, 1/1000

Skin: skin.

Hematology: Hemorrhagic disorders (neutropenia, all bloody hemocyst, leukopenia), anemia.

Kidney: Kidney disease, kidney toxicity when abusing all day.

Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sara Strawberry Children Nakorn 30 ml drugs in the following cases:

Hypersensitivity to paracetamol or any ingredients of the drug.

Caution when using

Paracetamol is relatively non -toxic to the dose of treatment. However, do not use more than 5 days. If the pain is severe or recurring, high fever or fever continuously, the disease is serious. If the pain persists for more than 5 days, swelling of redness or rheumatism in children younger than 12 years old, they must consult the physician immediately.

If there is a sensitive reaction, the drug must be stopped.

The drug contains Sorbitol excipients in the ingredients, if you do not tolerate some sugar, notify your doctor before using this Paracetamol.

Serious side effects on the skin, although the incidence is not high but serious, even life-threatening includes Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome: Toxic Epidermal Necrolysis (Ten) or Lyell syndrome, acute external pustules syndrome [Acute Generalized Exanthematous Puplosis (AGEPSIS).

Symptoms of the above syndrome are described as follows:

Steven-Johnson syndrome (SJS)

is a puffiness, bullous allergy around the natural cavities: eyes, nose, mouth, ears, genitals and anus. In addition, it may be accompanied by high fever, pneumonia, liver dysfunction. Diagnosis of Steven-Johnson Syndrome (SJS) when at least 2 naturally damaged cavities.

Poisoned skin necrosis syndrome (ten)

is the most severe allergy, including: Diverse skin lesions: measles, pink, roses or bulls, and damage quickly spread throughout the body.

Eye mucosa lesions: corneal inflammation, blind conjunctivitis, corneal ulcer.

Damage to the gastrointestinal mucosa: stomatitis, mouth mucosa, pharyngeal ulcer, esophagus, stomach, intestines.

Damage to the mucosa of genital tract, urinary tract.

There are also serious systemic symptoms such as gastrointestinal dengue fever, pneumonia, glomerulonephritis, hepatitis, ... high mortality rate of 15 - 30%.

Agep all -body pustules syndrome (AGEP)

Small sterile pustules arise on the spreading platform. Damage often appears in folds such as armpits, groin and face, then can spread body. Systemic symptoms are often fever, high neutrophilic blood test.

When detecting signs of rash on the first skin or any other hypersensitive reactions, patients need to stop using the drug.

Those who have been seriously respected by paracetamol skin reactions are not allowed to use the drug again and when they come to medical examination and treatment, they need to notify the medical staff on this issue.

The ability to drive and operate machinery

does not affect.

Pregnancy

Epidemiological studies during pregnancy do not show side effects due to the use of paracetamol at the recommended dose. Pregnant women should consult a doctor before use.

Breastfeeding period

Paracetamol is excreted through breast milk but does not mean clinical significance. There is no contraindications for women to breastfeed the published data.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion.

Out of alcohol too much and long may increase the risk of paracetamol toxic to the liver. Alcohol also increases the central neurological inhibition effect of Chlorpheniramin Maleat.

Anti -convulsions such as Phenytoin, Barbiturat, Carbamazepine causes enzyme induction in the liver microsom, which can increase the toxicity of the liver toxicity of paracetamol due to phenytoin metabolism and can lead to phenytoin poisoning.

Storage

Store at temperatures below 30 ° C, avoiding light.

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