Sartanpo OPV treatment for hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Losartan

Ingredient

Composition information	Content
Losartan	50mg

Uses

Indications

Sartanpo drugs are indicated in the following cases:

Treatment of hypertension. Can be used alone or in combination with other anti -hypertension drugs. Losartan and the main metabolites have a clogging and aldosteron secretion of Angiotensin II by preventing Angiotensin II selective, not attached to the AT1 receptor, found in many tissues (for example, blood vessel muscles, adrenal glands). Losartan is a competitive, reversible inhibitor of AT1 receptor.

Metabolic substances have a stronger activity from 10 to 40 times compared to Losartan, calculated by weight and is a non -competitive, reversible inhibitor of the AT1 receptor.

pharmacokinetics

After drinking, Losartan absorbs well through the gastrointestinal tract and initially metabolized through the liver, bioactivity of Losartan is about 33%. The average peak concentration of Losartan is within 1 hour and of the active metabolites of the drug achieved within 3-4 hours.

Losartan's waste time is about 2 hours and of metabolites about 6-9 hours. Both Losartan and metabolites are associated with 98% of plasma proteins, mainly albumin and they do not pass the blood -brain barrier. Losartan's distribution volume is about 34L and of metabolites with activity about 12L. Losartan Exports in urine in stools in the form of unchanged substances and metabolites.

Before taking Sartanpo OPV treatment for hypertension (3 blisters x 10 tablets)

How to use

oral medication, can take medicine when hungry or full.

Dosage

Dosage depending on each person. Usually the starting dose is 50mg once a day and the dose of 25mg/day is recommended in patients with a decrease in internal volume (for example, in people who are taking diuretics) and patients with a history of liver failure. Losartan's maximum hypotension is achieved after the beginning of treatment from 3 to 6 weeks.

Maintenance dose

25 - 100mg/day can be taken in 1 or 2 times.

If the blood pressure is not controlled at the dose used, 1-2 months must adjust the dosage of anti -hypertension drugs once.

If blood pressure is not completely controlled when using losartan alone, adding low -dose dosage. Hydrochlorothiazid proves the effect of force.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

The most common expression of overdose is probably hypotension and tachycardia, which may also experience slow heart rate due to sympathetic nerve stimulation (vagus nerve).

Handling

If symptomic hypotension occurs, supportive treatment must be treated. Both Losartan and metabolites are active, they cannot be removed by dialysis.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Sartanpo, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Hypotension.

Insomnia, dizziness. nose), sinusitis.

Lower blood pressure, chest pain, II atrial block, chest drum, slow sinus rhythm, fast heartbeat, face, blush.

anorexia, constipation, flatulence, vomiting, gastritis. Urea.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sartanpo drugs contraindicated in the following cases:

Hypersensitivity to Losartan or any ingredients of the drug.

Precautions when using

Patients with intravascular volume reduced (due to high dosage diuretic use), or other factors that can lead to hypotension.

Hepatic failure.

Renal artery stenosis.

Children: consult a doctor about the use of this drug.

The ability to drive and operate machinery

There has been no research on the impact of the operation of the train machinery.

Pregnancy

should not take the drug in the first 3 months of pregnancy. Contraindicated drugs for 3 months between and last month of pregnancy.

Breastfeeding period

Due to the possibility of harmful to breastfeeding children, deciding to stop breastfeeding or stopping the drug, taking into account the importance of the drug for the mother.

Drug interaction

Use at the same time with diuretics that keep potassium, potassium supplements, and potassium -containing salt that can lead to an increase in danger of serum potassium.

Losartan's anti -hypertension effect may be reduced by NSAID drugs (nonsteroidal anti -inflammatory).

Losartan drinks with cimetidine increases the area under the curve (AUC) of Losartan by about 18%, but does not affect the pharmacokinetics of the active metabolites of Losartan.

Take Losartan with Phenobarbital reduces about 20% of Losartan and of the active metabolites.

Cytochrome P450 inhibitors (such as fluconazole) may reduce the activity of Losartan.

Storage

At temperatures below 30 ° C, in a dry place, avoiding light.

Other drugs

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