Savi Gabapentin 300 medicine for epilepsy (3 blisters x 10 tablets)
Dosage form Box of 3 blisters x 10 tablets
Specifications Gabapentin
Ingredient
Thành phần cho 1 viên
| Composition information | Content |
| Gabapentin | 300mg |
Uses
Indications
Savi Gabapentin 300 medicine is indicated in the following cases:
In In vitro studies with Gabapentin marked by radiation, there is a position of Gabapentin associated with rat brain, including new cortex and hilly area. The strong binding force with protein in the animal brain tissue has been identified as a small auxiliary source for the voltage to activate calcium channels. However, Gabapentin's connected functional correlation, if any, still needs to be clarified.
pharmacokinetic pharmacokinetics
gabapentin absorbed through the gastrointestinal tract under saturated mechanism (when the dose increases, bioavailability decreases). The drug reaches the peak concentration in plasma after drinking 2 hours and reaches a stable concentration after 1-2 days. The effective serum concentration of the drug has not been determined. However, in a study, the number of convulsions only decreased in people with gabapentin serum levels per mg/liter (11.7 micromol/liter). Gabapentin plasma concentration is generally within 2 mg/liter (2 micrograms/ml) to 20 mg/liter (20 micrograms/ml).
Birth is about 60% when used at a dose of 1.8 g/24 hours and does not correspond to the dose, even when the dose increases over 1.8 g/24 hours of competition, it will decrease (bioavailability of about 35% when used with 4.8 g/24 hours). Food less affecting the speed and level of absorption.
In elderly patients and patients with impaired renal function, plasma gabapentin clearance is reduced. Gabapentin can be eliminated from plasma by hemolysis, so the dose adjustments for these patients are needed.
gabapentin is distributed throughout the body, entering breast milk, linking with very low plasma proteins (
Gabapentin is almost no metabolic in the body and excreted mainly through the kidneys in a constant form. Half of the mineral gabapentin 5 to 7 hours in people with normal kidney function.
Before taking Savi Gabapentin 300 medicine for epilepsy (3 blisters x 10 tablets)
How to use
Savi Gabapentin 300 medicine is used for oral sugar.
The time to take the drug does not depend on the meal.
Gabapentin is used as a secondary drug to coordinate with other anti -epileptic drugs. Used alone may not be effective.
Dosage
anti -epileptic
Adults and children over 12 years old
After that, the dose may increase every step of 300 mg per day, based on the patient's response, until the effective treatment is reached, usually 900 - 1800 mg/day, divided 3 times; Maximum not exceeding 2400 mg (8 tablets)/day.
Should divide the total daily dose for each drug and the medication distance should not exceed 12 hours. When using high doses can be divided 4 times/day.
For patients with impaired kidney function and hemolysis must reduce the dose; The appropriate dose needs to be adjusted according to the clearance of creatinine (CLCR), recommended as follows:
Creatinine clearance (ml/min)
Dosage
50 -70
600 - 1200 mg/day, divided 3 times.
30 - 49 300 - 600 mg/day, divided 3 times.
15 - 29
300 mg (once a day) - 300 mg/day, divided 3 times.
300 mg every day, divided 3 times. 200 - 300 mg (*).
(*) The loading dose is 300 - 400 mg for the first patient to use gabapentin, then 200 - 300 mg after every 4 hours of hemolysis.
Children from 6 to 12 years old:
The maintenance dose is 900 mg/day for children weighing from 26 - 36 kg and 1200 mg/day for children weighing from 37 kg to 50 kg, total doses/day are divided into 3 times.
3 -year -old children to under 6 years old: the first dose of 10 -15 mg/kg/day, divided 3 times; Increase the dose in 3 days to get a dose of 25-30 mg/kg/day for children 3-4 years or 25 - 30 mg/day for children 5 years old or more; Total dose/day is divided 3 times.
There is no evaluation of the use of gabapentin for children under 12 years old with renal function.
Treatment of pain caused by inflammation of the peripheral nerves
Adults
Take no more than 1800 mg/day. Divide 3 times. Or use as follows:
After that, the dose increases every step of 300 mg per day, based on the response of the patient, until the maximum dose is 1800 mg/day, the total dose/day is divided into 3 times.
Elderly
Dosage may be low due to poor kidney function.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Most cases of overdose recover after using supportive treatment.
There may be drugs from the body by hemolysis.
What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Savi Gabapentin 300, you may experience unwanted effects (ADR).
Gabapentin tolerates well. The ADR is usually mild or average and tends to gradually decrease when it continues to be treated. The most common ADRs for nerves and are often the cause of stopping the drug.
Common, ADR> 1/100
Other: impotence, virus infection.
Uncommon, 1/1000 Other: weight gain, liver. Rare, ADR Instructions on how to handle ADR Unwanted effects are usually mild or medium and tend to gradually decrease within 2 weeks of continuing treatment. Mobilization is often related to the dose. If the dose is reduced without helping, it is necessary to stop the drug. If there is a suspected Stevens - Johnson syndrome, the drug must be stopped.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Savi Gabapentin 300 drug contraindicated in the following cases:
Sensitive to gabapentin or any ingredients in the formula.
Precautions when using
Warning
There are behaviors and suicide intentions
Antiepile Drugs Drugs, AEDS), including Gabapentin, often increases the risk of intentions or suicide behavior in patients using these drugs for indications for any treatment. Patients treated with any AEDS need to be monitored and monitored the appearance of any signs of depression, thoughts or suicide behaviors and/or any abnormal changes in mood or behavior.
Potentially creating tumors
In the standard of clinical in vivo research on lifetime cancer, there is a high rate of unexpected masses in the pancreatic acinar cells that are determined in male rats, but are not seen in female mice. The clinical significance of this finding is not clear. Clinical experience in using the product before being launched to the market (premarketing) of Gabapentin does not provide direct means to assess the potential causing tumors in humans.
Sudden and unknown death in patients with epilepsy
During the use of the product before giving to the market of Gabapentin, there were 8 unexplained deaths that were reported in a total of 2,203 treated patients (2103 patients taking drugs annually). Some of these can represent the lyrics related to seizures, in which epilepsy is not observed, such as at night. This represents 0,0038 patients deaths each year, although this rate exceeds the expected of the healthy patients suitable for age and gender.
Information for patients
Patients, their caregivers, and families need advice that anti -epileptic drugs, including gabapentin, can increase the risk of suicidal thinking and behavior and need to be notified of the need to be warned of the appearance of negative symptoms of depression, any abnormal changes in mood or behavior, or the appearance of suicide, self -killing behavior.
Precautions
Use cautiously for people with a history of mental disorders, people with impaired kidney function and hemolysis, train operators or machinery.
The drug can cause false positive when testing proteinuria.
The ability to drive and operate machinery
Do not take the drug while driving or operating machines because of some adverse reactions such as dizziness and drowsiness.
Pregnancy
gabapentin causes teratogen on rodents. On pregnant people, there is no same effect. However, only medication for pregnant women when really necessary and consider higher benefits than the risk for the fetus.
Breastfeeding period
When used orally, gabapentin can be through breast milk. The effect of the drug on infants is still unknown, so the lead using gabapentin for women during breastfeeding is really necessary and has carefully considered the benefits higher than the risk risk.
Medicinal interaction
When used simultaneously, Gabapentin does not change the pharmacokinetics of commonly used anti -epilepsy drugs such as carbamazepine, phenytoin, Valproic acid, phenobarbital, diazepam.
Anti -acid drugs reduce the bioavailability of gabapentin by about 20% due to the impact on the absorption of the drug. Gabapentin must be used after at least 2 hours of antacids.
The excretion of gabapentin through the kidneys is not affected by probenecide.
Gabapentin's excretion through the kidneys is reduced when used in combination with cimetidine, but this decrease is not clinical significance.
Storage
In the dry place, the temperature does not exceed 30 ° C. Avoid light.
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