Savi Olanzapine 10 medicine treats schizophrenia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Olanzapine

Ingredient

Composition information	Content
Olanzapine	10mg

Uses

Indications

Savi olanzapine 10 drugs are indicated in the following cases:

Treatment of schizophrenic mental illness, with symptoms of hearing, seeing or feeling things that do not exist, have false beliefs, suspicion and isolate living with people.

Treatment of emotional attacks that are severe (an agitation or excitement).

Prevent the recurrence of the above symptoms in patients with bipolar disorders that olanzapin is effective in the emotional attacks. In olanzapin clinical studies with affinity (Ki;

Physiological electrophoresis studies have shown that olanzapin selectively reduced the activation of dopaminergic nerve cells in Mesolimbic (A10) but little effect on the pattern (A9) in motor function. Olanzapin reduces conditional avoidance response, which is a test that determines the anti -psychotic effect when using the dose lower than the dose that causes the remedy, is a side effect on the motor function. Unlike some other anti -psychotic drugs, olanzapin causes increased response in the test of "reducing anxiety". In a single dosage study (10 mg), the Roengent method is used to cut the Positron (Positron Emission Tomography, PET) in healthy volunteers, Olanzapin occupies the 5HT2A receptor more than the Dopamine D2 receptor.

Moreover, a picture study using Roengent method of transmitting a single photon emission computer tomography, specter) in schizophrenia shows that patients respond to olanzapin occupying D2, of the pattern less than those who respond to Risperidon and some other anti -chaotic drugs, but equivalent to patients in response to other patients responding to other patients with patients responding to other patients with patients responding to other patients responding to other patients with the patients responding to other patients responding to other patients responding to other patients responding to other patients responding to other patients responding to other patients with other patients responding to other patients responding to other patients with patients with other patients responding to other patients responding to other patients responding to other patients responding Clozapin.

Both of the two tests are verified by Placebo and 2 of the three tests with comparative substances on 2900 schizophrenia patients with both positive and negative symptoms, showing that olanzapin has improved more statistically positive and negative symptoms.

pharmacokinetic

absorption

olanzapin absorbs well when drinking, reaching a plasma peak concentration within 5 - 8 hours. Food does not affect the absorption.

Distribution

About 93% olanzapin binds to plasma proteins when the concentration is from 7 to 1000 ng/ml. Olanzapin is mainly connected to albumin and α-acid glycoprotein.

Metabolism

olanzapin is metabolized in the liver through a conjugate and oxidative mechanism. The main metabolite is 10-N-glucuronid and does not pass the brain barrier. Cytochrom P450-CYP1A2 and P450-CYP2D6 are involved in the creation of N-Desmethyl and 2-Hydroxymethyl metabolites. Both metabolites have a much lower pharmacological activity in vivo than olanzapin in animal studies. Pharmacological effects are mainly caused by olanzapin.

Elimination

The average selling time in healthy people depends on age and gender. About 57% and 30% of the amount of excreted drugs correspond to urine and feces, mainly in the form of metabolites, a small part (7%) in the form of intact.

Before taking Savi Olanzapine 10 medicine treats schizophrenia (3 blisters x 10 tablets)

How to use

take medicine under the guidance of a doctor or pharmacist. Savi Olanzapine 10 medicine is taken orally, can be taken during meals or away from meals. If you feel long -lasting sleep, you can take medicine in the evening before going to bed. Should take medicine at the same time every day. Do not arbitrarily stop the drug.

Dosage

Dosage 5 - 20 mg/day. The initial dose and the maintenance dose of each patient are performed as directed by the treating doctor. The maximum dose is 20 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Savi Olanzapine 10, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Neuroscope: Sleeping, Surgery, insomnia, dizziness, pronunciation disorders, fever, nightmares, refreshments, forgetting, manic.

digestive: indigestion, constipation, weight gain, dry mouth, nausea, vomiting, increase appetite.

liver: increase ALT.

muscle: weak muscle, tremor, fall.

Cardiovascular: Hypotension, fast heart, peripheral edema, chest pain.

Skin: burning.

Metabolic: hypercholesterol, hyperkemia, hyperglycemia

Hematology: leukopenia, neutropenia.

Rare, ADR

Other: pancreatitis, malignant neuron syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Savi Olanzapine 10 contraindicated in the following cases:

Patients with hypersensitivity to olanzapin or any ingredients of this drug (with signs such as rash, itching, swelling of the face, swelling of the lips, shortness of breath).

breastfeeding women.

Precautions when using

Caution in the following objects:

older and dementia.

There is an abnormal movement mainly on the face or tongue.

Fever, fast breathing, sweating, stiffness and drowsiness.

gain weight.

Hyperglythemia and lipid (triglyceride and cholesterol). If you are over 65 years old, you should monitor your blood pressure.

The ability to drive and operate machinery

Because the drug can cause sleep and dizziness, be careful to use this drug when driving, operating machinery.

Pregnancy

There are no strict and complete studies in pregnancy. Women are advised to notify the doctor if they are pregnant or intend to get pregnant while taking olanzapin. Due to limited experience in humans, this medication should only be used in pregnancy when the benefits bring more dangers to the fetus.

Breastfeeding period

Should not breastfeed while taking olanzapin.

Drug interaction

Avoid not to coordinate

Do not coordinate olanzapin with levomethady due to increased risk of toxicity on the heart (extending the QT range, torsion, cardiac arrest). With Metoclopramide due to an increase in the risk of outsider of extracurricular syndrome, malignant neuron syndrome.

The possibility of other drugs that affect olanzapin

Simultaneous use of olanzapin with central nervous system inhibitors: alcohol, benzodiazepine derivatives increase the effect of lowering the posture effect of olanzapin.

Fluoxetin (CYP2D6 inhibitors), the only dose of antacids (magnesi, aluminum) or cimetidine: does not affect the bioavailability of Olanzapin orally. However, simultaneous use of activated carbon will reduce the bioavailability of oral olinzapin to 50 to 60%.

Cypt inhibitors (caffeine, erythromycin, ciprofloxacin, quinidine, some antidepressants such as fluvoxamine) increase blood levels, thus increasing the effects and toxicity of olanzapin. Do not use dopamine, adrenalin or other sympathetic effects on the beta receptor in patients being treated with olanzapin, due to the ability to worsen hypotension.

Cypt (phenobarbital, carbamazepin, phenytoin, rifampicin, omeprazol, nicotine) reduces in the blood.

The metabolism of olanzapin may increase due to smoking because of the active sensor CYP1A2.

Olanzapin ability affects other drugs

olanzapin does not inhibit the metabolism of three -round antidepressants (CYP2D6), Warfarin (CYP2C9), Theophylllin (CYP1A2) or Diazepam (CYP3A4 and CYP2C19). Olanzapin also has no interaction when used with lithium or biperiden. No need to adjust Valproat dose when used simultaneously with olanzapin.

olanzapin increases the effect (constipation, dry mouth, urinary retention, sedation, visual disorders) of anti -cholinergic drugs, increasing the hypotension effect of anti -hypertension drugs.

olanzapin may reduce the effects of Parkinson's medications.

Storage

to be out of reach of children. Store the drug in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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