Savi Rosuvastatin 5 medicine for hypercholesteroline blood cholesterol (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Rosuvastatin

Ingredient

Composition information	Content
Rosuvastatin	5mg

Uses

indications

Savi Rosuvastatin 5 medicine is indicated in the following cases:

The treatment of primary cholesterol (IIA, including hyperlested hyperlemomic blood cholesterol) or mixed blood lipid disorders (type IIB) in adults and children aged 6 and older:

is a supportive therapy for diet diet when patients do not fully respond to diet diets and other non -medication therapies.

Deathly hyperlested hypertension treatment in adults and children from 6 years old and older:

Use to support diets and other lipid reduction treatments (such as LDL blood extraction) or when these therapies are inappropriate. In order to prevent patients at high risk of primary cardiovascular events, support to adjust other risks.

A Mevalonate, a precursor of cholesterol. The main impact position of rosuvastatin is the liver, the target organs to make cholesterol.

Dynamic pharmacokinetics

Absolute bioavailability of about 20%. The liver is widely distributed in the liver is the main place to synthesize cholesterol and LDL-C clearance.

Rosuvastatin is less metabolized (about 10%). CYP2C9 is the main isenzyme involved in metabolism; 2C19, 3A4 and 2D6 participate at a lower level.

About 90% of the doses of rosuvastatin are eliminated unchanged through feces (including the active ingredient absorbed and not absorbed) and the rest is excreted into urine.

Before taking Savi Rosuvastatin 5 medicine for hypercholesteroline blood cholesterol (3 blisters x 10 tablets)

How to use

Savi Rosuvastatin pills form tablets for oral film.

Before starting treatment, the patient must follow a standard diet to reduce cholesterol and continue to maintain this regime during treatment.

Rosuvastatin can be used at any time of the day, during or outside the meal.

Dosage

Dosage in hypercholesteroline blood cholesterol

Adults:

The recommended starting dose is 5 mg or 10 mg, orally once a day for both patients who have never used Statin groups and patients from HMG-CAA Reductase inhibitors to rosvastatin. The dose after every 4 weeks if needed.

Adults:

Take a dose of 20 mg/day.

Children from 6 - 17 years old:

Hyperty blood cholesterol hyperliper: The starting dose is 5 mg/day.

Children from 6 - 9 years old: The common dose is 5 - 10 mg, 1 time/day. The dose over 10 mg has not been evaluated in this object. The dose over 20 mg has not been evaluated in this object.

Children from 6-17 years old: Maximum recommended dose is 20 mg/time/day. The starting dose is 5 - 10 mg/time/day depending on age, weight and history of using statin.

Patients with renal failure:

No need to adjust the dose in patients with mild to medium renal failure. muscle disease:

The starting dose of 5 mg.

Contraindicated Rosuvastatin for patients with progressive liver disease (Child-Pugh above 9). Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? There is no specific treatment when overdose. If overdose occurs, symptomatic treatment and supportive measures. Hemorrhage does not significantly increase the clearance of rosuvastatin.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Savi Rosuvastatin 5 medicine, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Endocrine: diabetes.

nerve: headache , dizziness.

digestive: constipation , nausea, abdominal pain.

musculoskeletal: muscle pain.

Body: weakness .

rarely, rare, ADR

Blood and lymphatic system: thrombocytopenia.

skin: itching, rash, urticaria. immune: Hypersensitivity reactions including angioedema. digestive: pancreatitis . liver: Increase liver enzyme.

musculoskeletal: muscle disease, muscle pepper.

Instructions on how to handle ADR

Condens the medication and immediately notify the doctor if the patient appears allergic reactions:

Difficulty breathing or not with swelling of the face, lips, tongue and throat. These symptoms often occur in children and teenagers than adults.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Savi Rosuvastatin 5 contraindications in the following cases:

Patients with progressive liver disease, including prolonged increased serum transaminase and unknown cause, and when serum transaminase concentration increases more than 3 upper limits of normal levels.

Patients with severe renal impairment (Creatinine clearance

Patients with muscle disease.

Patients who are taking ciclosporin.

Pregnant and lactating women, women may be pregnant without using appropriate contraception.

Dosage 40 mg/day Contraindications for cases: Average renal failure (Creatinine clearance

Caution when using

Need to be very cautious when taking drugs for patients in the following cases:

proteinuria has been recorded in patients treated with high -dose rosuvastatin, especially the dose of 40 mg and is not a warning sign of acute or progressive renal disease. It is necessary to assess the kidney function during monitoring of patients who have been treated at a dose of 40 mg.

The statin group is at risk of causing harmful reactions to the muscle system such as muscle atrophy, muscle inflammation, especially for patients with risk factors such as patients over 65 years old, patients with uncontrolled thyroid defects, patients with kidney disease.

Need to closely monitor harmful reactions when taking the drug. Muscle effects such as muscle and muscle pain and some cases of muscle pattern have been recorded in patients treated with rosuvastatin at all doses and especially at the doses> 20 mg.

Increase the concentration of creatinine kinase (CK) according to the dose observed in patients using rosuvastatin. If the concentration of CK increases (> 5 times on normal), treatment should be temporarily suspended.

Increase transaminase at the dose recorded in a small number of patients using rosuvastatin. Rosuvastatin should be stopped or reduced if serum transaminase concentration is 3 times the upper limit of normal levels.

The ability to drive and operate machinery

studies to determine the effect of rosuvastatin on driving and operating machinery has not been done. However, based on the pharmaceutical properties, Rosuvastatin cannot affect these possibilities. When driving or operating machinery, it should be noted that dizziness may occur during treatment.

Pregnancy

Rosuvastatin is contraindicated in pregnant women. If the patient is pregnant while treating with rosuvastatin, the drug should be stopped immediately.

breastfeeding period

rosuvastatin contraindicated in nursing women.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Ciclosporin, Gemfibrozil, Ezetimib drugs when used simultaneously with rosuvastatin increases the concentration of rosuvastatin in plasma.

antacids, eryhthromycin simultaneously with rosuvastatin reduces rosuvastatin levels in plasma

There are also many other drugs that increase rosuvastatin levels and adjust the dose when used in combination.

Rosuvastatin can increase the value of INR in patients using vitamin K antagonists.

There has been a report on the pattern when using a combination of rosuvastatin and ccid fusidic, so it should not be used in combination with 2 drugs.

Storage

Store drugs in a dry place, the temperature does not exceed 30 ° C, avoiding light.

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