Savi Telmisartan 40 medicine for hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Telmisartan

Ingredient

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Composition information	Content
Telmisartan	40mg

Uses

indications

Savi Telmisartan 40 drug is indicated in the following cases:

Treatment of hypertension. The specific antagonist of the Angiotensin II receptor (AT1) in the smooth and adrenal walls.

Telmisartan blocks selectively the attachment of angiotensin II into the AT1 receptor in the blood vessel and adrenal glands, causing vasodilation and reducing the effects of aldosteron.

Unlike angiotensin enzyme inhibitors (the drug group is widely used to treat hypertension), Angiotensin II receptor antagonists do not inhibit bradykinin chemistry, so they do not cause persistent dry cough (an unwanted effect when treated with ACE inhibitors). Therefore, Angiotensin II receptor antagonists are used for people who have to stop using ACE inhibitors because they persist.

In humans, the dose of 80 mg Telmisartan inhibits almost completely hypertension due to angiotensin II. Inhibiting effects (hypotension) are maintained for 24 hours and still measures 48 hours after drinking. After taking the first dose, the effect of reducing blood pressure manifests itself slowly within the first 3 hours. Typically, the maximum reduction of arterial blood pressure reached 4-8 weeks after the beginning of treatment.

Prolonged effects when long -term treatment. In hypertension people, Telmisartan reduces systolic and diastolic blood pressure without changing the heart frequency. Telmisartan's anti -hypertension effect is equivalent to other anti -hypertension drugs.

When stopping treatment of Telmisartan suddenly, the blood pressure again gradually again for a few days as not yet treated, but there is no strong increase in the phenomenon.

Pharmacokinetics

absorption

Telmisartan is rapidly absorbed through the gastrointestinal tract. Absolute oral bioavailability depends on the dose: about 42% after taking the dose of 40 mg and 58% after or taking the dose of 160 mg. The presence of food reduces the bioavailability of Telmisartan (down about 6% when using a dose of 40 mg). After drinking, the highest drug concentration in plasma is achieved after 0.5 - 1 hour.

Distribution

more than 99% of Telmisartan is attached to plasma proteins, mainly on albumin and alpha-1-acid glycoprotein. The attachment to protein is constant, not affected by the change of dose. The distribution volume is about 500 l.

Metabolism, excretion

After intravenous injection or taken Telmisartan, most of the given doses (more than 97%) are eliminated in the form of constant biliary tract into the feces, only very small amount (less than 1%) discharged through the urine.

Telmisartan's sale time is about 24 hours, the peak rate of Telmisartan is about 15-20%. Telmisartan is converted into an incompatible form of acylglucuronide, only seen in plasma and urine. Telmisartan with recommended dose does not cause significant clinical accumulation.

Before taking Savi Telmisartan 40 medicine for hypertension (3 blisters x 10 tablets)

How to use

oral medication. Drink once a day, no meals.

Dosage

Adults: 40 mg/day. For some patients, only dose 20 mg/day/day. If necessary, may increase to a maximum dose of 80 mg/day/day.

Telmisartan can be combined with thiazide diuretic. Before increasing the dose, it should be noted that the maximum anti -hypertension effect is achieved between the 4th and 8th weeks from the beginning of treatment.

renal failure: No dose adjustment.

Hepatic failure: If mild or medium liver failure, daily dose must not exceed 40 mg/daily.

Elderly: No dose adjustment.

Children under 18 years of age: Safety and efficiency have not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptomatic and support treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Savi Telmisartan 40, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Body: fatigue, headache, dizziness, limb edema, sweating.

Central nervous system: agitation. digestive: dry mouth, nausea, abdominal pain, acid reflux, indigestion, flatulence, anorexia, diarrhea.

urinary tract: Reduce kidney function, increase creatinine and nitrogen urea (bun), urinary tract infections.

Respiratory: Sore throat, sinusitis, upper respiratory tract infection (cough, congestion or ear pain, fever, nasal congestion, runny nose, sneezing, sore throat).

osteoarthritis: back pain, pain and muscle spasm.

Metabolism: hyperkalemia.

Rare, 1/10000

Systemic: Evaluation.

Eye: visual disorders.

Cardiovascular: tachycardia, reducing blood pressure or fainting (common in people with blood volume reduced or reduced salt, treatment with diuretics, especially in standing posture). Digestive: stomach and intestines bleeding. skin: ban, urticaria, itching. liver: Increase liver enzymes. blood: hemoglobin, neutrophils. Metabolism: hyperuricemia, hypercholesteroline blood cholesterol.

Instructions on how to handle ADR

Treatment of symptomatic hypotension: Put the patient on your back, if it is necessary to inferalize the physiological saline solution.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Savi Telmisartan 40 contraindications in the following cases:

Hypersensitivity to the drug.

Pregnant and lactating women.

Severe kidney failure. Severe liver failure. biliary clogged.

Be cautious when using

monitor blood potassium concentration, especially in the elderly and kidney failure. Reduce the starting dose in these patients.

Aortic valve stenosis or mitral valve.

African myocardial disease.

Severe congestive heart failure (may be particularly sensitive to changes in the Renin - Angiotensin - Ordosteron system, accompanied by a decrease in urinary, increased blood urea, acute renal failure that can cause death).

Dehydration (decreased volume and sodium blood due to vomiting, loose stools, although prolonged diuretics, separation, salt restriction diet) increases the risk of symptoms. This disorder must be adjusted before using Telmisartan or reducing the dose and closely monitoring at the beginning of treatment.

Stomach ulcers, duodenum or other stomach disease (increase the risk of stomach and intestinal bleeding).

Mild and moderate liver failure.

Kidney artery stenosis.

Mild and medium renal function.

The ability to drive and operate machinery

Tell patients to be cautious when driving, using machines or doing other things can be dangerous, because it can be dizzy, dizzy due to lower blood pressure.

Pregnancy

due to caution, Telmisartan should not be used for the first 3 months of pregnancy. If you intend to get pregnant, other drugs should be replaced before pregnancy.

Contraindicated Telmisartan from the 3rd month of pregnancy because the drug is directly acting on the renin -asotensin system, which can cause damage to the fetus such as hypotension, renal failure with recovery or non -recovery, anchuria, reducing skull production in infants, causing pregnancy or newborns, less amniotic fluid in the mother (possibly due to reduced renal function of pregnancy). newspaper.

When detecting pregnancy, Telmisartan must be stopped as soon as possible.

The period of breastfeeding

Contraindicated to use Telmisartan during breastfeeding because it is not known whether Telmisartan will excrete in breast milk or not. To ensure the safety of breastfeeding, it is necessary to decide to stop breastfeeding or stop the drug, depending on the importance of the drug for the mother.

Drug interaction

Not enough data to evaluate safety and effectiveness when using Telmisartan simultaneously with ACE inhibitors or beta-adrenergic blockers. Telmisartan may increase the effect of reducing blood pressure of these drugs.

Digoxin: Concentrated with Telmisartan increases the concentration of Digoxin in serum, so it is necessary to monitor the concentration of Digoxin in the blood at the beginning of treatment, adjusting and stopping Telmisartan to avoid the possibility of digoxin overdose.

Diuretics: Increases the hypotension effect of Telmisartan.

Warfarin: Concentrated with Telmisartan for 10 days reduces the concentration of warfarin in the blood but does not change the INR.

Potassium diuretics: The supplement of potassium or use of other drugs that cause hyperkalemia may increase the effect of hyperkalemia of Telmisartan.

Storage

In the dry place, the temperature does not exceed 30 ° C. Avoid light.

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