Savi Trimetazidine 35MR medicine treats angina (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Trimetazidine

Ingredient

Composition informationContent
Trimetazidine35mg

Uses

indications

The drug is indicated for adults in supplementary therapy/support for existing treatment to treat symptoms in stable angina patients with adequate control or non -tolerated patients with other angina therapy.

Pharmacokology

Mechanism of action

Trimetazidine inhibits the oxidation of fatty acids by inhibiting the 3-ketoacyl-coa thiolase enzymes in ischemic cells, energy obtained during glucose oxidation requires less oxygen consumption than oxidation beta. Promoting glucose oxidation will help optimize cell energy processes. Therefore maintaining appropriate energy metabolism during anemia.

Pharmacokology

In patients with local heart anemia, trimetazidine acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidine has anti -anemia effect but does not affect hemodynamics.

Dynamic pharmacokinetics

trimetazidine when taken is absorbed very quickly and reaches the peak concentration in plasma before 2 hours from drinking. The maximum concentration of the drug in plasma, after taking a single dose of trimetazidine 20 mg, reaches about 55 ng/ml, the balance state of the blood in the blood is reached from 24 - 36 hours after repeating a dose and is very stable during treatment.

With a distribution of 4.8 liters/kg shows the level of dispersion of the drug to the tissues. Low protein mounting ratio, the measured value in vitro is 16%. Half of the excretion of trimetazidine is 6 hours. The drug is excreted mainly in urine in the form of unprovered.

Before taking Savi Trimetazidine 35MR medicine treats angina (3 blisters x 10 tablets)

How to use

take medicine with 1 glass of water at meals.

Dosage

Adults

Take 1 capsule/time in the morning and evening.

Patients with average renal impairment (clearine clearance 30 - 60 ml/minute)

recommended dose is 1 tablet 35 mg in the morning.

Elderly patients

There may be higher than normal trimetazidine sensitivity levels due to the decline in renal function by age. Precautions when calculating the dose with elderly patients.

Children

The safety and effectiveness of trimetazidine for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

No report on overdose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

  • Neurological: dizziness, headache.
    • digestive: abdominal pain, diarrhea, indigestion, nausea and vomiting.
  • Skin and subcutaneous tissue: rash, urticaria.
    • Systemic: weakness.

    Rare, 1/1000

  • Heart: Brushing chest drum, suspense, extra mind, fast heartbeat.
    • blood vessel: Hypotension arterial, flushed, hypotension, vertical posture, dizziness or falling.

    Unknown frequency

  • Neurological: Parkinson's symptoms (Run, slow and difficult movement, muscle tone), unstable gait, vacuum syndrome, relevant movement disorders can be recovered after medication.
    • digestive: constipation.

    Skin and subcutaneous tissue: Excavity of the acute pus (AGEP), Evana. blood and lymphatic system: granulocytosis, thrombocytopenia, thrombocytopenic rash.

    Hepatitis: Hepatitis.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    trimetazidine 35MR Savi is contraindicated for use in the following cases:

  • Too hypersensitivity to the active ingredient or any dozens is listed in the product protection formula.
  • Parkinson patients, Parkinson's symptoms, tremor, vacuum syndrome and other relevant movement disorders.
  • Severe renal failure (Creatinine clearance

    Be cautious when using

    trimetazidine can cause or worsen Parkinson's symptoms (Run, slow movement and difficulty, increase muscle tone). Therefore, patients, especially elderly patients, need to be checked and monitored regularly. In suspicious cases, patients need to be taken to neurologists for appropriate examination.

    When encountering movement disorders such as Parkinson's symptoms, irritability, tremor, unsteady gait, should immediately stop using trimetazidine. These cases occur and often recover after stopping the drug. The majority of patients recover after stopping the drug about 4 months. If Parkinson's symptoms continue to happen for more than 4 months after not, consulting neurologists.

    may have a self, unstable gait or hypotension, especially in patients who are taking hypertension drugs.

    Be careful when prescribing trimetazidine for patients with high sensitivity levels such as:

  • Patients with average renal failure.

    • Patients over 75 years old.

    The ability to drive and operate machinery

    trimetazidine can cause symptoms such as dizziness and drowsiness, so it can affect the ability to drive and operate machinery.

    Pregnancy

    Animal research results have not been confirmed for sure whether or not the teratical effect of trimetazidine. When used for pregnant women, should consider effectiveness and consequences.

    The period of breastfeeding

    There is no evidence of the presence of trimetazidine in breast milk, so the best choice is not to breastfeed during trimetazidine treatment.

    Interactive drug

    There has been no interaction with any drug. Trimetazidine is not an induction drug or an enzyme that inhibits the liver metabolism in the liver and is likely that trimetazidine does not interact with many metabolic drugs in the liver. Anyway, you still need to be careful to monitor when coordinating with another drug.

    Storage

    Store drugs in dry, temperatures below 30 ° C.

    Other drugs

    Disclaimer

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