Scilin M30 100iu/ml bioton injection mixture (10ml)

Dosage form Bottle x 10ml
Specifications Insulin Human

Ingredient

Composition information	Content
Insulin Human	100UI

Uses

indications

Scilin M30 100 IU/mL is indicated in the following cases:

Type diabetes (Insulin dependent). In the blood. of the pancreatic langerhans island. Blood glucose concentration is the main factor that regulates insulin secretion. In normal people, insulin is uneven, most ate. The main effect of insulin on stabilization of blood sugar levels obtained after insulin was attached to specific receptors on the cell surface of the tissue sensitive to insulin, especially the liver, muscle pattern and adipose tissue.

insulin inhibits the manufacture of glucose in the liver, increases the use of peripheral glucose and thus reduces blood glucose. It also inhibits fatty tissue resolution and thus prevents the formation of ceton forms. In addition, insulin also has the assimilation effect due to the effects on metabolism of glucid, lipid and protid. Insulin is decomposed in liver, muscle and kidney tissue.

insulin is used in replacement therapy in patients with complete or partial insulin deficiency. Human insulin is a product of recombinant DNA technology using an non -pathogenic laboratory of Escherichia Coli.

Insulin reunited with less antigens than conventional insulin preparations are purified by pure method. The human insulin is absorbed through the subcutaneous tissue slightly faster than the insulin pig or cow. Although half -life in the blood is very short (half -life of insulin after intravenous injection is only about 5 minutes). The effect time of most insulin preparations is much longer due to preparation. Practicing, heavy labor causes blood glucose to decrease, thus increasing the effects of insulin. The distance and composition of meals also affect the effects of insulin.

Dynamic pharmacokinetics

in healthy people 5% insulin attached to plasma proteins. Insulin is detected in cerebrospinal fluid where there is an insulin concentration of about 25% of the total serum insulin. Insulin is metabolized in the liver and kidneys. Some metabolism in fat and muscle organization.

Insulin metabolism in healthy people and diabetes is the same. They are eliminated through the kidneys. A small number of insulin is eliminated in bile. The sale time of insulin is about 4 minutes. Hepatic impairment and renal failure may increase the excretion time of insulin. Elderly patients eliminate insulin slower and prolonged hypoglycemia.

Before taking Scilin M30 100iu/ml bioton injection mixture (10ml)

How to use

SCILIN M30 injection 100 IU/mL subcutaneously, only new intramuscular cases.

Dosage

Dosage according to the needs of each patient and are adjusted according to the results of regular monitoring of blood glucose concentration.

Normal starting dose in adults:

Inject about 20-40 IU/day, increasing gradually about 2 IU/day, until the blood glucose concentration is reached. The total dose of the day does not exceed 80 IU is abnormal and can think of insulin resistance. Many treatments include using insulin -acting insulin with an intermediate insulin such as insulin isophan or zinc insulin mixture. Such coordination is usually injected twice a day with 2/3 of the total dose of the day before breakfast and the remaining 1/3 is injected before dinner.

Diabetes coma, kitonic acidosis:

insulin is used to handle emergency detectonic acidosis due to diabetes. Only insulin is used shortly. Adulin adjustment by blood glucose concentration.

Children under 12 years:

Insulin injection starting dose is recommended in children early detecting average hyperlem of blood glucose and no meton urine is 0.3 to 0.5 IU/kg/day, subcutaneous injection.

For patients with liver failure, kidney failure, the elderly over 65 years:

Dosage and how to follow the doctor's instructions, depending on the needs of each patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

intense hunger, anxiety, difficulty concentration, tremor of hands and feet, sweating, vomiting. In case of mild hypoglycemia, you only need to drink soft drinks or eat hydratcarbon foods. Patients should be rested. Therefore, patients with diabetes should carry a few pills of sugar, glucose or sweets.

Serious hypoglycemia can lead to seizures, consciousness or death.

How to handle:

If a coma is needed to transmit glucose into a vein. If the insulin overdose will cause a decrease in blood potassium, leading to a reduced muscle tone. In case of acute hypoglycemia, patients cannot eat, so 1 g of glycogen should be injected into the muscle and/or intravenous glucose injection.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using the Scilin M30 100 IU/mL you may experience unwanted effects (ADR).

Hypoglycemia: Cases of hypoglycemia often appear suddenly such as sweating, dizziness, tremor of hands and feet, feeling hungry, anxiety, the feeling of ants crawling in the hands, legs, lips or tongue, concentrated disorders, insomnia, sleep disorders, loss of control, visual disorders, speech disorders, intelligence, irritability. Serious hypoglycemia leads to unconsciousness, temporary or permanent or permanent brain function or can lead to death. (Atrophy or fat tissue).

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Scilin M30 100 IU/ml contraindicated in the following cases:

Hypoglycemia.

Hypersensitivity to insulin or any part of the drug.

Pure Insulin intermediate and prolonged effects in case of blood acidosis or charm of diabetes.

Be cautious when using

only doctors can change insulin dosage or recommend insulin or change one form.

Patients should notify the doctor if there is any early manifestation of allergies to any insulin fluid as well as other drugs, food, boxes or color products.

During insulin treatment must monitor blood sugar and urine, HBA1C or blood fructose in the blood.

Patients should learn how to check blood and urine by themselves using simple tests (for example, a line test). In case of incorrect testing, immediately notify the doctor.

In different patients, hypoglycemic symptoms can occur at different times and degrees. Therefore, patients should learn how to identify the symptoms of hypoglycemia for themselves. If the symptoms occur regularly even at a mild level, you should go to the doctor to change the dose of insulin or diet.

Patients with animal insulin transfers to human insulin should use smaller insulin doses (capable of causing hypoglycemia). Some patients do not feel the early symptoms of hypoglycemia after strong insulin injection by animal insulin injection.

Patients with long -term diabetes or diabetes with neurological complications or patients used in parallel with beta - adrenolytycal drugs and reaching the blood glucose imbalance, the early symptoms of hypoglycemia will also be weaker. Both hyperglycemia and hypoglycemia if not treated can lead to loss of consciousness, coma or death.

Patients should go to the doctor most regularly when they start using insulin.

It is very important to keep a regular and nutritious diet.

Reduced insulin demand if there is an increase in physical activity, strong movement of the muscle that insulin injection will accelerate hypoglycemia.

When the patient moves to places where at least 2 times change the time zone, you should go to the doctor to change the insulin injection time. While flying, keep insulin in hand luggage, not in luggage compartment.

Insulin dosage changes if symptoms of high fever, serious infection (requiring significant increase in insulin demand), mental injury, fatigue, digestive disorders with vomiting, nausea, diarrhea, gastrointestinal disorders, absorption disorders. These cases must always consult a doctor. Therefore, blood sugar and urine need to be controlled regularly and if the results are improperly, it is imperative to go to the doctor. Compliance with insulin dosage and reasonable diet.

Even the drugs sold on the market without a doctor's application (such as flu, fever, pain relief, medications reduced in eating demand) can change insulin demand. Therefore, every time this medication needs to consult a doctor.

Patients with insulin eliminated renal impairment are reduced and longer -acting time.

Patients with diabetes due to pancreatic or diabetes combined with Addison disease requires very small insulin dosage.

Patients with pituitary disorders, adrenal glands or thyroids demand also change.

Long -term insulin injection can cause insulin resistance reaction, if this case occurs, the higher insulin dose should be injected.

The ability to drive and operate machinery

affect the treatment of insulin at the right dose to the ability to drive is not studied. Patients may be disabled due to hyperglycemia causing central neurological disorders with symptoms: headache, anxiety, double view, coordination disorders and distance assessment (distance disorders). When starting with insulin treatment, changing insulin, stress or physical exercise too much to significantly change blood sugar levels, the disorders of driving capacity and operating possible machinery.

Pregnancy

Pregnant women with diabetes still require insulin. Maintaining accurate blood sugar levels during pregnancy is extremely important because hyperglycemia in pregnant women can affect the fetus. In the first 3 months of pregnancy, insulin demand decreases rapidly and it is necessary to reduce insulin doses and will increase gradually in the middle 3 months and the last 3 months of pregnancy, usually equal to 75% of insulin dose before pregnancy. After giving birth, the new insulin needs fell rapidly.

breastfeeding period

While insulin treatment can still be breastfeeding because this hormone is dissolved in the gastrointestinal tract. Insulin demand while breastfeeding is lower than before pregnancy and returning to normal after 6 to 9 months.

Drug interaction

should not be mixed with animal insulin and mixed insulin from other manufacturers.

Many drugs are used (for example, some anti -hypertension drugs, cardiovascular drugs, blood lipids, thyroid replacement drugs, epilepsy treatments, salicylate, antibiotics, contraceptives) can affect the effects of insulin and insulin treatment effect.

drugs and substances that increase the effect of insulin

Beta blockers, chloroquine, ACE inhibitors, Mao inhibitors, Methyldopa, Clonidine, Pentamidine, Salicylate, Steroids, Cyclophosphamide, Sulfonamid antibiotics, tetracycline, quinolone antibiotics and ethyl alcohol.

Drugs that reduce the effects of insulin

diltiazem, dobutamine, estrogen (including oral contraceptives), phenothiazine, phenytoin, armor hormone, heparin, calcitonin, corticosteroids, antiviral drugs for people infected with HIV, vitamins and thiazide diuretics.

Storage

Store drugs at a temperature of 2 - 80C. Do not freeze. Avoid light.

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