Scilin M30 40iu/ml bioton injection mixture (10ml)

Dosage form Bottle x 10ml
Specifications Human Insulin

Ingredient

Composition information	Content
Human Insulin	40iu/ml

Uses

indications

Scilin M30 drugs are indicated in the following cases:

Diabetes treatment in patients need insulin. to store glycogen in the liver; And to convert glucose into fat.

When used for patients with diabetes with the appropriate dosage and dosage, blood sugar is maintained within a reasonable range, the urine is still relatively without glucose and ceton, while preventing acidosis and coma due to diabetes.

Different preparations of recombinant insulin (Scilin M30) are formulated to provide short, intermediate and two -phase treatment effects. In clinical practice, the effect time of insulin may change compared to the specified time as follows. As with all insulin preparations, the difference between and in patients may occur depending on the injection site, dosage, diet, temperature and physical activity.

The starting time works for about 30 minutes, the highest time is 2 - 8 hours and lasts 24 hours.

pharmacokinetics

Distribution

In healthy people, about 5% insulin binds to blood proteins. Insulin is also detected in cerebrospinal fluid with a concentration of approximately 25% of the total serum insulin concentration.

Metabolism

insulin is metabolized by liver and kidneys and at a lower level in adipose and muscle tissue.

Elimination

insulin is eliminated through the kidneys and a small amount is also eliminated through the bile. The sale time is about 4 minutes. Hepatic failure or renal failure, often related to old patients, can slow down the elimination of insulin.

Before taking Scilin M30 40iu/ml bioton injection mixture (10ml)

How to use

Recombinant insulin products (SCILIN M30) for subcutaneous injection. The recombinant insulin (Scilin M30) can be used through intramuscular methods. For self -use patients, the subcutaneous injection is prioritized.

Use recombinant insulin syringe (Scilin M30): Only use the appropriate injection pen recommended by the doctor. In case of emergency, conventional syringe can be used.

Dosage

Dosage is determined by a doctor according to the needs of the patient.

Insulin recombinant (Scilin M30) should be used 15 minutes before meals. The mixing should only be done if there is a doctor's guidance.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Overdose causes hypoglycemia.

Treatment of hypoglycemia from mild to medium: If the patient is awake and cooperating, feeding the existing sugar food (such as jelly, honey). After that, you should use carbohydrates that work longer (such as sandwiches or dried fruits).

Serious hypoglycemia treatment: Glucagon is often used to treat hypoglycemia outside the hospital.

For adults and children 5 years of age and older cannot be taken food or liquid, the dose of glucagon is 1 mg injected subcutaneous or intramuscularly. If accessible by intravenous lines, 20 to 30 ml of 50% glucose via a safe located tube.

For children under 5 years old, the dose of Glucagon is 0.5 mg intramuscularly or subcutaneously, then feeding while awake. If it is accessible by intravenous line, the glucose solution should be transmitted 10% 2 ml/kg bolus, followed by 0.1 ml/kg/minute until the patient is completely awake.

Patients will wake up within 6 minutes after glucagon and within 4 to 5 minutes after glucose injection.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Scilin M30, you may experience unwanted effects (ADR).

Common, ADR> 1/100

No report.

Uncommon, 1/1000

No report.

Not determined frequency

Metabolism: Hypoglycemia (usually occurs suddenly) including increased sweating; dizzy; trembling; feelings of hunger; worry; tingling sensation in the hands, feet, lips or tongue; concentrated disorders; sleepy, sleep disorders; loss of autonomy; the expansion of the pupil; visual disorders; Language disorders; depression; irritability. Hyperglycemia, ketone acidosis, nausea, vomiting, drowsiness, dry red skin, dry mouth, urinating, thirst and anorexia as well as breath smell like acetone.

Other: allergies to insulin; insulin resistance; Fat dysplasia after insulin (atrophy or excessive growing of fat tissue in the injection area).

Instructions on how to handle ADR

Fat distribution disorders can be minimized by alternating the injection site.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SCILIN M30 drug is contraindicated in the following cases:

Hypoglycemia (low blood sugar).

Hypersensitivity to human insulin or any excipients.

Insulin intravenous injection.

Be cautious when using

any changes of insulin (for example, brand, origin, purity, strength) must be done carefully and only under medical supervision. Adjusting the dose may be required.

The appropriate test should be conducted before the beginning of recombinant insulin treatment (Scilin M30) in patients who have appeared general allergic reactions with insulin preparations.

Insulin demand may be affected by high fever; Severe infection; emotional tension; Gastrointestinal disorders, especially nausea, vomiting and diarrhea; Pituitary disorders, adrenal glands or thyroid. The usual dose will need to be considered by a doctor in these cases and patients should monitor blood glucose concentration in blood/ urine regularly.

The most common side effects that insulin users encounter are hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar). If these conditions are serious, need medical assistance immediately.

Hypoglycemia may be due to too much insulin use; missed or delayed meals; increase exercise level; Infection or disease; consumption of alcoholic beverages; Drugs that reduce blood sugar.

Early warning symptoms of hypoglycemia may be less obvious or different under certain conditions, for example: transferring from animal insulin to human insulin, long periods of diabetes, diabetes neuropathy, using beta blockers. The onset and intensity of symptoms may vary between patients. If such symptoms occur frequently, whether mild, patients should see a doctor to change the dose of insulin or diet. If not sure about the symptoms, patients should learn how to monitor the level of glucose in the blood and urine regularly to get used to the symptoms of hypoglycemia.

Hyperglycemia may be due to not being insulin sufficiently; Eat more significantly than the recommended meal plan; fever; significant emotional stress. In patients with type 1 diabetes, prolonged hyperglycemia, if not adjusted, can lead to keton acidosis.The long -term use of insulin can lead to insulin resistance. The larger dosage will be required in these patients.

Patients who intend to move over the two time zones should consult a doctor about adjusting insulin injection schedule.

Exercise can reduce the body's insulin demand and some time after activity. It can also increase the starting speed of an insulin dose, especially if the injection area is related. Patients should discuss with the doctor about changes in the medication mode to suit the exercise, for example, not injected with recombinant insulin (Scilin M30) into the thigh before running.

Concentriously using human insulin products with pioglitazone: Cases of heart failure have been reported when using simultaneous insulin with pioglitazone, especially in patients with risk factors for heart failure. This should be considered before using any combination treatment with recombinant insulin (Scilin M30) with Pioglitazone. When combined treatment is performed, patients need to monitor the signs and symptoms of heart failure, increase body weight and edema. If cardiovascular symptoms are worse, pioglitazone should be stopped.

Used for people with kidney and liver: insulin is metabolized mainly in the liver and kidneys. Its effect time lasts in patients with renal or liver impairment. Needs to reduce the dose in these patients.

The ability to drive and operate machinery

People do not know if using the right dose of insulin can affect the ability to drive or operate machinery. However, hyperglycemia can lead to central nervous system disorders affecting vision and distance assessment. Patients should be cautious when driving or using machinery in situations that may have a significant difference in blood sugar levels, such as when starting treatment with insulin, changing insulin preparations, when stressed and excessive effort.

Pregnancy

The essential thing is to maintain continuous control of diabetes that need insulin during pregnancy because hyperglycemia can be harmful to the fetus. Controlling this condition may be more difficult because insulin demand changes during pregnancy. Patients who are pregnant or intend to get pregnant should consult a doctor.

breastfeeding period

There is no limitation in the treatment of diabetes with insulin during breastfeeding. Nursing mother's insulin treatment is expected to not affect the baby. However, it may be necessary to adjust the insulin dosage.

Interactive drug

many drugs used often affect the activity of insulin. Simultaneous use may need to adjust recombinant insulin dose (Scilin M30). Patients being treated with insulin must always notify the doctor if they are taking other drugs.

The following substances can reduce the patient's insulin demand: hypoglycemic drugs, beta blockers, enzyme inhibitors, Mao inhibitors (antidepressants), methyldopa, salicylate, alcohol, assimilated steroids, sulfonamide antibiotics, tetracycline, antibacterial quinolone, alphabotic blocker .

The following substances may increase the patient's insulin demand: some diuretics, estrogen (including birth control pills), thyroid replacement therapy, heparin, corticosteroid, growth hormone, adrenalin, isoniazid, phenothiazid, beta-2 stimulus (such as salbutamol, terbutaline).

Storage

Store at 2 ° C to 8 ° C. Do not let the pills freeze. Avoid light.

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