SCILIN NEUTIFICATION PLACE OF SCILIN N 40IU/ML Bioton Treatment of Type 1 (10ml) diabetes

Dosage form Box X 10ml
Specifications Isophane Human Insulin

Ingredient

Composition information	Content
Isophane Human Insulin	40iu/ml

Uses

indications

Scilin n drugs are indicated in the following cases:

Treatment of type I diabetes (insulin depends).

Type II diabetes (regardless of insulin) when synthetic anti -diabetes drugs are no longer effective, when acidosis, charm of diabetes, severe bacterial infections, large surgery.

Emergency hyperglycemia in: diabetes contaminated with cetonic acid, coma with hyperglycemia, osmotic increased without infection in the blood. Retinal disease progresses due to diabetes.

Diabetes in pregnant women, diabetes during pregnancy. Blood glucose concentration is the main factor that regulates insulin secretion, in normal people, uneven secretion insulin: most after meals. The main effect of insulin on stabilization of blood glucose concentration occurs after insulin has been attached to specific receptors on the cell surface of sensitive tissues with insulin, especially the liver, muscle pattern and insulin adipose tissue inhibiting glucose in the liver, increasing the use of glucose in the peripheral and thus reducing glucose levels in the blood.

It also inhibits fat resolution and thus prevents the formation of ceton forms. In addition, insulin also has the assimilation effect due to the effects on metabolism of glucid, lipid and protid. Insulin is decomposed in liver, muscle and kidney tissue.

insulin is used in replacement therapy in patients with completely deficiency or part of insulin.

insulin is absorbed quite quickly after subcutaneous injection and although half -life in the blood is very short. Practicing, heavy labor causes blood glucose to decrease thus increasing the effects of insulin. Infections and obesity reduce the effects of insulin. The distance and composition of meals also affect the effects of insulin.

Three main types of insulin preparations are: Short -acting insulin, medium -acting insulin and prolonged acting insulin.

SCILIN N is an insulin type that has a long -lasting effect.

According to the clinical results, the effect time of insulin is stated in the following version:

Daceller The starting time has the effect Maximum time -effect time The long -term effect time Now

insulin is metabolized in the liver and kidneys. Some metabolic in muscles and adipose tissue. Insulin metabolism in healthy people and diabetes is the same.

They are eliminated through the kidneys. A small number of insulin is eliminated by biliary tract. The semi -canceling time is about 4 minutes. Hepatic impairment and renal failure may increase insulin eradication time. Elderly patients eliminate insulin slower and prolonged hypoglycemia.

Before taking SCILIN NEUTIFICATION PLACE OF SCILIN N 40IU/ML Bioton Treatment of Type 1 (10ml) diabetes

How to use

Sugar used: Usually subcutaneously, only new intramuscular cases.

Do not get intravenously.

Scrilin injection 30-60 minutes before meals.

suspended fluid must have a homogeneous turbidity (opaque or like milk). Should not be used if after mixing but the mixture is still clear or white film at the bottom of the jar, there are clouds that are cloudy in the jar or white particles that stick to the wall of the jar makes the fluid look like frozen.

Dosage

Insulin therapy is performed at the first hospital hospital. The dosage is determined by the physician according to the needs of each patient and must be adjusted according to the results of regular monitoring of blood glucose levels.

Adults

Normal starting dose in adults is about 20 - 40 IU/day, increasing gradually about 2 IU/day, until the blood glucose level is reached. The World Health Organization recommends that glucose levels in the venous blood at the time of hunger must be kept within 3.3 to 5.6 mmol/liter (60 to 100 mg/decilite) and not low less than 3 mmol/liter (55 mg/decompite). The total daily dose exceeds 80 IU is abnormal and can think of insulin resistance.

Many treatments include using insulin -acting insulin with an intermediate -acting insulin, such as insulin isophan or zinc mixture suspension. Such coordination is usually injected twice a day with 2/3 of the total dose of the day before breakfast and the remaining 1/3 is injected before dinner.

Diabetes coma, ketone acidosis: insulin is also an essential part of the treatment of gear emergency detectonic acidosis due to diabetes. Only insulin is used to prevent solubility.

Adjust the insulin dose according to blood glucose concentration.

Children

Insulin injection starting dose is recommended in children early detecting average hyperlem of blood glucose and no meton urine is 0.3 to 0.5 IU/kg/day, subcutaneous injection.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

When an overdose of insulin, the symptoms of hypoglycemia occur: intense hunger, anxiety sensation, difficulty focusing, tremor of limbs, sweating, vomiting.

In case of mild hypoglycemia, just drink soft drinks or eat hydrated - carbon foods. Patients should rest. Therefore, patients with diabetes should carry a few pills of sugar, glucose or sweets. Do not recommend eating chocolate containing fat that slows glucose absorption. Serious hypoglycemia can lead to convulsions, consciousness or death.

If a coma is needed to transmit glucose into a vein. If an overdose of insulin will cause hypokalamia (hypokalemia), leads to a miopathy (mopathy). In the case of hypoglycemia of acute blood glucose, patients cannot be eaten, so 1 g glycogen is injected into muscle and/or intravenous glucose injection.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Scilin N, you may experience unwanted effects (ADR).

Hypoglycemia

Symptoms of hypoglycemia usually appear suddenly. They may include: sweating, dizziness, tremor of limbs, feelings of hunger, anxiety, the feeling of crawling on the arms, legs, lips or tongue, concentrated disorders, insomnia, sleep disorders, loss of control, pupils, visual disorders, speech disorders, stagnation, irritability.

Serious hypoglycemia can lead to unconsciousness, and can lead to temporary or permanent brain function impairment or can lead to death.

Hyperglycemia

Patients with type I diabetes, prolonged hyperglycemia that can lead to ketone acidosis. The first symptoms of acidosis will appear slowly within a few hours or even a few days: Nausea, vomiting, drowsiness, blush, dry mouth, urinary tract, thirst, anorexia, ceton smell. If inaccurate, increased blood glucose can lead to ketone acidosis, dehydration, coma and death.

Other

Other side effects occasionally occur during biosynthetic insulin treatment: allergies to insulin, insulin resistance, fat disorder after insulin injection (atrophy or fat hypertrophy in the injection area).

Fatty tissue atrophy in the skin's injecting (more commonly common when taking regular insulin).

However, fat dysplasia may reduce minimum by changing the injection sides.

Instructions on how to handle ADR

The local reactions will gradually end during treatment.

Atrophy of subcutaneous fat: Can be cured by injecting insulin animal insulin or human insulin inside or around the shrinking.

Fatty tissue hypertrophy: can be avoided by rotating the injection site.

Hypoglycemia: Patients must know the warning signs (for example, sweat, dizziness, tremor) and can overcome by eating food or drinking soft drinks.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SCILIN N drugs in the following cases:

Lower blood glucose.

Hypersensitivity to insulin or any component of an intravenous intravenous drug in the form of insulin.

Cases of high blood ceton, acidosis and diabetes coma.

Be cautious when using

only doctors can change insulin dosage or recommend mixing insulin or change one form.

Patients should notify the doctor if there is any early manifestation of allergies to any insulin fluid as well as other drugs, food, boxes or color products.

During the treatment of insulin, the amount of blood and urine glucose must be monitored, HBA1C and the amount of fructose in the blood.

Patients should learn how to check blood and urine by themselves using simple tests (e.g. tests). In case of incorrect testing, immediately notify the doctor.

In different patients, symptoms of hypoglycemia may occur at different times at different levels. Therefore, patients should learn how to self -identify the symptoms of hypoglycemia for themselves. If these symptoms occur regularly even mildly, you should still go to the doctor to change the dose of insulin or diet.

Patients who transfer animal insulin to human insulin should use smaller insulin doses (capable of causing blood glucose). Some patients do not feel the early symptoms of hypoglycemia after a strong human insulin injection with animal insulin injection.

Patients with long -term diabetes or diabetes with neurological complications or patients used in parallel with beta - adrenolytycal drugs and reaches the imbalance of blood glucose levels, the early symptoms of hypoglycemia will also be weaker than increased blood glucose and hypoglycemia if left untreated can lead to consciousness, comet.

Patients should go to the doctor the most regularly when starting insulin.

It is very important to keep a regular and nutritious diet.

Reduced insulin demand if there is an increase in physical activity; The strong exercise of the muscle that insulin injection will accelerate the hypoglycemia of blood glucose (for example, insulin injection into the thigh before running).

When the patient moves to places where at least twice the time zone, you should go to the doctor to change the insulin injection time. While flying, insulin should be kept in hand luggage, not in luggage compartment (because it should not be frozen insulin).

Insulin dosage changes if symptoms of high fever, severe infections (requiring significant increase in insulin demand), mental injuries, fatigue and digestive disorders with vomiting, nausea, diarrhea, gastric digestive disorders, absorption disorders. These cases must always consult a doctor. Therefore, the amount of blood sugar and urine needs to be controlled regularly and if the results are incorrectly required to go to the doctor. Compliance with insulin dosage and reasonable diet.

Even the drugs sold on the market without a doctor's application (such as flu, fever, pain relief, medications reduced in eating demand) can change insulin demand. Therefore, every time these drugs need to consult a doctor.

Patients with insulin eliminated renal impairment are reduced and longer -acting time.

Patients with diabetes due to pancreatic or diabetes combined with Addison disease requires very small insulin dosage. Patients with pituitary disorders, adrenal glands or thyroid gland demand also change.

Long -term insulin injection can cause insulin resistance reaction, if this case occurs, the higher insulin dose should be injected.

The ability to drive and operate machinery

affect the treatment of insulin at the right dose to the ability to drive is not studied. Patients may be disabled due to hyperglycemia causing central neurological disorders with symptoms: headache, anxiety, double vision, coordination disorders and distance assessment (visual disorders). At the beginning of insulin treatment, the change of insulin, stress or physical activity is too hard to change the amount of blood glucose, the disorders of the ability to drive and operate the machine may occur.

Advice to control blood glucose during long trips.

Pregnancy

Pregnant women with diabetes still require insulin. Maintaining accurate blood glucose levels during pregnancy is extremely important because of increased blood glucose in pregnant women can affect the fetus. In the first 3 months of pregnancy, insulin demand decreases rapidly and it is necessary to reduce insulin doses and will increase gradually in the middle 3 months and the last 3 months of pregnancy, usually equal to 75% of insulin dose before pregnancy. After giving birth, the new insulin needs fell rapidly.

breastfeeding period

While insulin treatment can still be breastfeeding because this hormone is dissolved in the digestive tract. Insulin demand while breastfeeding is lower than before pregnancy and returning to normal after 6 to 9 months.

Drug interaction

Scilin fluid should not be mixed with animal insulin and synthetic insulin made from other manufacturers. Many common drugs (for example, some anti -hypertension drugs, cardiovascular drugs, lipid lipids, thyroid replacement drugs, epilepsy drugs, salicylate, antibiotics, contraceptives) can affect the effects of insulin and the effect of insulin treatment.

Therefore, patients should always inform the doctor for temporary or long -term medications. If the drug has never been used before, you must ask for your doctor's advice. Patients who come to the doctor for reasons other than diabetes must also notify the doctor about their insulin treatment.

drugs and substances that increase the effect of insulin

Beta blockers, chloroquin, ACE inhibitors, antididge (antididge), methyldopa, Clonidine, Pentamidine, Salicy Late, Steroid is assimilated, Cyclophosphamide antibiotic Sulfonamide, Tetracycline, Quinolin and Ethyl alcohol group.

Drugs that reduce the effects of insulin

diltiazem, dobutamine, estrogen (both contraceptives), phenothiazide, phenytoin, armor hormones, heparin, calcitonin, corticosteride, anti -virus drugs for HIV, vitamins and thiazide diuretics.

Cavalry

Scilin fluid should not be mixed with animal insulin and synthetic insulin made from other manufacturers.

Storage

Store drugs at temperatures 2 ° C - 8 ° C. Do not freeze medicine, avoid light.

Store at a temperature not exceeding 25 ° C after opening.

Other drugs

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