SCILIN R 40IU/ml of bioton injection

Dosage form Box X 10ml
Specifications Regular Human Insulin

Ingredient

Composition information	Content
Regular Human Insulin	40iu/ml

Uses

indications

Scilin R drugs are indicated in the following cases:

Treatment of diabetes type I (insulin dependent). Ceton infection in the blood. Polypeptide was secreted by the beta cells of the pancreatic langerhans. Blood glucose concentration is the main factor that regulates insulin secretion. In normal people insulin is uneven, the most after meals. The main effect of insulin on stabilization of blood glucose concentration occurs after insulin is attached to specific receptors on the cell surface of the tissue sensitive to insulin, especially the liver, muscle pattern and adipose tissue.

insulin inhibits glucose in the liver, increases the use of peripheral glucose and thus reduces blood glucose levels. It also inhibits fat resolution and thus prevents the formation of ceton forms. In addition, insulin also has the assimilation effect due to the effects on metabolism of glucid, lipid and protid. Insulin is decomposed in liver, muscle and kidney tissue.

insulin is used in replacement therapy in patients with completely deficiency or part of insulin.

Insulin is absorbed quite quickly after subcutaneous injection, half -life eliminated in plasma is very short. Practicing, heavy labor causes blood glucose to decrease thus increasing the effects of insulin. Infections and obesity reduce the effects of insulin. The distance and composition of meals also affect the effects of insulin.

Three main types of insulin preparations are: Short -acting insulin, medium -acting insulin and prolonged acting insulin.

SCILIN R is an insulin that has a short time.

According to clinical results, the drug starts to work after 30 minutes, maximum effect time of 1-3 hours, the effect time lasts up to 8 hours.

Dynamic pharmacokinetics

in healthy people about 5% insulin attached to blood proteins. Insulin is also detected in cerebrospinal fluid where there is an insulin concentration of about 25% of the total serum insulin.

insulin is metabolized in the liver and kidneys. Some metabolic in muscles and adipose tissue. Insulin metabolism in healthy people and diabetes is the same. They are eliminated through the kidneys. A small number of insulin is eliminated by biliary tract. The semi -canceling time is about 4 minutes. Hepatic impairment and renal failure may increase insulin eradication time. Elderly patients eliminate insulin slower, leading to prolonged hypoglycemia.

Before taking SCILIN R 40IU/ml of bioton injection

How to use

drugs used in the skin, intravenously or intramuscularly.

Dosage

Insulin therapy is performed at the first hospital hospital. The dosage is decided by the doctor according to the needs of each patient and must be adjusted according to the results of regular monitoring of blood glucose levels of normal starting dose in adults about 20 - 40 lu/day, increasing about 2 IU/day, until the desired blood glucose level is reached. The World Health Organization recommends that glucose levels in the venous blood at an hunger must be kept within 3.3 - 5.6 mmol/l (60 - 100 mg/dL) and must not be less than 3 mmol/l (55 mg/dL). The total daily dose exceeds 80 IU is abnormal and can think of insulin resistance.

Many treatments include using insulin -acting insulin with an intermediate -acting insulin, such as insulin isophane or zinc mixture. Such coordination is usually injected twice a day with 2/3 of the total dose of the day before breakfast and the remaining 1/3 is injected before dinner.

Diabetes coma, kitonic infection

insulin is also an essential part of the treatment of diabetes due to diabetes. Only insulin is used shortly.

The first dose: 10 - 15 IU insulin soluble (or 0.15 IU/kg) intravenously.

Insulin continuous intravenous drip injection: 10 IU per hour (or 0.1 IU/kg/hour).

Or other way: Intramuscularly insulin, the first dose of 10 IU (or 0.1 IU/kg) per hour but avoid using this method for patients with hypotension because they cannot predict the absorption of drugs.

Children

Insulin injection starting dose is recommended in children who are detected early in medium blood glucose and no meton urine is 0.3 - 0.5 IU/kg/day, subcutaneous injection.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In case of lowering mild blood glucose just drink soft drinks or eat carbohydrate foods. Patients should rest. Therefore, patients with diabetes should carry a few pills of sugar, glucose or sweets. Do not recommend eating chocolate containing fat that slows glucose absorption. Serious hypoglycemia can lead to convulsions, consciousness or death. If the patient is in a coma, it is necessary to transmit intravenous glucose.

Insulin overdose can cause hypokalemia (hypotension), leading to myopathy tone reduction (Myopathy). In the case of hypoglycemia of acute blood glucose, patients cannot be eaten, so 1 g glycogen is injected into muscle and/or intravenous glucose injection.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Scilin R, you may experience unwanted effects (ADR).

Hypoglycemia

Symptoms of hypoglycemia usually appear suddenly. They may include: sweating, dizziness, tremor of limbs, feelings of hunger, anxiety, the feeling of crawling on the arms, legs, lips or tongue, concentrated disorders, insomnia, sleep disorders, loss of control, pupils, visual disorders, speech disorders, stagnation, irritability.

Serious hypoglycemia can lead to unconsciousness, and can lead to temporary or permanent brain function impairment or can lead to death.

Hyperglycemia

Patients with type I diabetes, prolonged hyperlemia of blood glucose can lead to meton acidosis. The first symptoms of acidosis will appear slowly within a few hours or even a few days: Nausea, vomiting, drowsiness, blush, dry mouth, urinary tract, thirst, anorexia, ceton smell. More severe can lead to dehydration, coma and death.

Other

Other side effects occasionally occur during biosynthetic insulin treatment: allergies to insulin, insulin resistance, fat disorder after insulin injection (atrophy or fat hypertrophy in the injection area).

Fatty tissue atrophy in the skin's injecting (more commonly common when taking regular insulin).

However, fat dysplasia may reduce minimum by changing the injection sides.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

The local reactions will gradually end during treatment.

Atrophy of subcutaneous fat: Can be cured by injecting insulin animal insulin or human insulin inside or around the shrinking.

Fatty tissue hypertrophy: can be avoided by rotating the injection site.

Hypoglycemia: Patients must know the signs of warning (for example, sweat, dizziness, tremor) and can be treated by eating food or drinking soft drinks.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

SCILIN R is contraindicated in the following cases:

Lower blood glucose.

Hypersensitivity to insulin or any part of the drug.

Insulin intravenous injection.

Cases of high blood ceton, acidosis and diabetes coma.

Be cautious when using

only doctors can change insulin dosage or recommend mixing insulin or one form to another.

Patients should notify the doctor if there is any early manifestation of allergies to any insulin fluid as well as other drugs, food, boxes or color products.

During the treatment of insulin, blood and urine glucose must be monitored, HBA1C and blood fructose in the blood.

Patients should learn how to check blood and urine by themselves using simple tests (e.g. tests). In case of incorrect testing, immediately notify the doctor.

In different patients, symptoms of hypoglycemia may occur at different times at different levels. Therefore, patients should learn how to self -identify the symptoms of hypoglycemia for themselves. If these symptoms occur regularly even mildly, you should still see a doctor to change the dose of insulin or diet.

Patients who move from animal insulin to human insulin should use smaller insulin doses (due to the potential to lower blood glucose). Some patients do not feel the early symptoms of hypoglycemia after human insulin injection with animal insulin injection.

Patients with long -term diabetes or diabetes with neurological complications or patients used in parallel with beta - adreno lyrical drugs, the early symptoms of hypoglycemia will also be weaker. Hypoglycemia if left untreated can lead to loss of consciousness, coma or death.

Patients should go to the doctor most regularly when starting with insulin.

Keep a regular and nutritious diet.

Reduced insulin demand if there is an increase in physical activity. When the muscles are strong, the insulin injection will accelerate the hypoglycemia of blood glucose (such as insulin injection into the thigh before running).

When patients move to places where at least twice change the time zone, go to the doctor to change the insulin injection time. While flying, insulin should be kept in hand luggage, not in luggage compartment (because it should not be frozen insulin).

Insulin dosage changes if symptoms of high fever, severe infections (requiring significant increase in insulin demand), mental injuries, fatigue and digestive disorders with vomiting, nausea, diarrhea, gastrointestinal disorders, absorption disorders. These cases need a doctor's advice. Therefore, blood sugar and urine need to be controlled regularly and if the results are not required to go to the doctor. Compliance with insulin dosage and reasonable diet.

Even the drugs sold on the market without a doctor's application (such as flu, fever, pain relief, medications reduced in eating demand) can change insulin demand. Therefore, when using these drugs, you need to consult a doctor.

Patients with insulin eliminated renal impairment are reduced and longer -acting time.

Patients with diabetes due to pancreatic or diabetes combined with Addison disease requires very small insulin dosage.

Patients with pituitary disorders, adrenal glands or thyroids demand also change.

Long -term insulin injection can cause resistance reaction, if this case occurs, higher insulin dose should be injected.

The ability to drive and operate machinery

affect insulin treatment to the ability to drive is not studied. Hyperglycemia can cause central neurological disorders with symptoms: headache, anxiety, double vision, coordination disorders and distance assessment (visual disorders). At the beginning of insulin treatment, changing insulin, stress or physical exercise too much, significantly changes blood glucose, so the disorders of driving and operating machinery can occur.

Pregnancy

Pregnant women with diabetes still require insulin. Maintaining accurate blood glucose levels during pregnancy is extremely important because of increased blood glucose in pregnant women can affect the fetus. In the first 3 months of pregnancy, insulin demand decreases rapidly, so it is necessary to reduce insulin doses and will increase gradually in the middle 3 months and the last 3 months of pregnancy, usually equal to 75% of insulin dose before pregnancy. After giving birth, insulin demand decreases rapidly.

breastfeeding period

While insulin treatment can still be breastfeeding because this hormone is dissolved in the gastrointestinal tract. Insulin demand while breastfeeding is lower than before pregnancy and returning to normal after 6 to 9 months.

Drug interaction

Scilin should not be mixed with animal insulin and synthetic insulin made from other manufacturers. Many common medications (for example, some anti -hypertension drugs, cardiovascular drugs, lipids that reduce blood lipids, thyroid replacement drugs, epilepsy treatments, salicylate, antibiotics, contraceptives) may affect the effects of insulin and the effect of insulin treatment. Therefore, patients should notify the doctor for temporary or long -term medications. If you start taking the medication but have never used it before, you must ask for your doctor's advice. Patients who go to the doctor for reasons other than diabetes must also notify the doctor about their insulin treatment.

drugs and substances that increase the effect of insulin

Beta blockers, chloroquine, ACE inhibitors, antidepressive inhibitors, methyldopa, clonidine, pentamidine, salicylate, assimilated steroids, cyclophosphamide antibiotic sulfonamide, tetracycline, quinolone antibiotics and ethyl alcohol.

Drugs that reduce the effects of insulin

diltiazem, dobutamine, estrogen (both contraceptives), phenothiazide, phenytoin, thyroid hormone, heparin, calcitonin, corticosteroids, antivirus drugs for HIV -infected people, vitamins and thiazide diuretics.

Storage

Store drugs at a temperature of 2 - 8 ° C. Do not freeze medicine, avoid light.

Store at a temperature not exceeding 25 ° C after opening.

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