Scofi Merap eye drops Short -term treatment of eye inflammation responding to corticosteroids (10ml)

Dosage form Box X 10ml
Specifications Dexamethasone, neomycin, polymyxin b sulfate

Ingredient

Composition information	Content
Dexamethasone	10mg
Neomycin	35000iu
Polymyxin b sulfate	60000iu

Uses

Indications

Scofi Merap eye is indicated for short -term treatment of eye inflammation that responds to corticosteroids when considering the need for antibacterial drugs, after excluding the presence of fungal and virus disease.

Pharmacokology

Pharmacological Group: Medicinal Medicine. Corticosteroid combination with anti -bacterial drugs

ATC code: S01CA01

Mechanism of action

Scofi eye is two effects: anti -inflammatory effects of dexamethasone and bactericidal effects of two Neomycin and polymyxin antibiotics b.

Dexamethasone is a synthetic glucocorticoid, a group of corticosteroids with strong anti -inflammatory and good anti -inflammatory effects on eye tissue. Corticosteroids reduce inflammation to many different agents and delay or slow down the wound recovery process. Because corticosteroids can inhibit the body's resistance mechanism against infections, in special cases, when the effect of inhibiting clinical immunomemomatic immunosuppressants, the use of corticosteroids with polymyxin B antibiotics is an antibiotic lipopeptide antibiotic, has bactericidal effects by the mechanism associated with phospholipids on the bacterial cell wall, changing the bacteria, causing bacteria, bacteria, bacteria, bacteria, bacteria, bacteria Inner composition.

Polymyxin B acts on most Gram -negative bacteria, but does not work with anaerobic bacteria and neomycin gram -positive bacteria is an aminoglycoside antibiotic with broad spectrum, which has a bactericidal effect thanks to the mechanism of inhibiting bacterial biosynthesis of bacteria by attaching to the subunit of Ribosom sensitive bacteria.

Medicine resistance mechanism

The anti -drug mechanism with polymyxin B is derived from chromosomes and is not common. The change of phospholipids on the cell membrane plays a role in drug resistance.

The anti -drug mechanism with Neomycin may be due to the following mechanisms:

Change the 30S subunit of bacterial ribosom. Genes with general information of these active enzymes can be carried by bacterial or plasmid chromosomes.

sensitive bacteria:

Aerobic Gram -positive bacteria: Bacillus Cereus, Bacillus Megaterium, Bacillus Pumilus, Bacillus Simplex, Corynebacterium vccolens, Corynebacterium bovis, corynebacterium macginleyi, Corynebacterium propinquum Pseudodiphtheriticum, Staphylococcus aureus (susceptible to methicillin-MSSA). Staphylococcus Capitis, Staphylococcus Epidermidis (susceptible to methicillin-MSSE), Staphylococcus pasteuri. Staphylococcus Warneri, Streptococcus mutans

Aerobic gram -negative bacteria: Haemophilus Influenza, Klebsiella Pneumonia, Moraxella Catatrhalis, Moraxella Lacunata, Pseudomonas Aeruginosa, SERRATIA spp.

Bacteria may have problems with resistance:

Staphylococcus epidermidis (methicillin -resistant - mrse), Staphylococcus hominis, Staphylococcus lugdunensis

Natural resistance bacteria:

Gram -positive bacteria when: Enterococci Faecalis, Staphylococcus aureus (Methicillin - MRSA), Streptococcus mitis, Streptococcus pneumoniae. Learning

dexamethasone can be significantly absorbed after use on the spot on the skin and eyes, causing systemic effect. A significant amount of dexamethasone can be absorbed through the eye tissue and contribute to the effect of dexamethasone in the treatment of inflammatory inflammation of the eye.

Polymyxin B Sulfate is not absorbed from the digestive tract or through the intact skin. Although intact cornea epithelium prevents the permeability of polymyxin B into the corneal parenchyma, the treatment concentration is still achieved in the parenchyma when the epithelial layer is damaged. Polymyxin B is not significantly absorbed into the lens after injection in the conjunctiva or small eye.

Neomycin is less absorbed from the gastrointestinal tract, after use on the spot the amount of drug is absorbed negligible to cause a whole body effect. The absorption of the drug may increase when the mucosa is inflamed or damaged. After being absorbed, Neomycin quickly excreted the kidneys in activity.

Before taking Scofi Merap eye drops Short -term treatment of eye inflammation responding to corticosteroids (10ml)

How to use

Smor eye SCOFO MERAP eye is only using small eyes, shaking thoroughly before use.

To avoid the infection into the tip of the drip and the drug chaos, do not let the drip tip of the vial in contact with the eyelids, the surrounding or any object. Cover after use.

Dosage

used in children, adults, including the elderly:

Small cases of light, 1 to 2 drops of drugs into the conjunctiva bag of the eye of the inflammatory eye, 4 to 6 times daily. Constantly treating too early.

No more than 20 ml. Do not add more drugs without additional reviews.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

There is no case of overdose.

Signs and symptoms during Scofi overdose are similar to unwanted effects that have been recorded in some patients (spotted keratitis, erythema, increased tears, edema and itchy eyelids).

Due to the characteristics of localized format, it is expected that there is no toxicity when used with recommended doses on the eye or when taking the wrong vial.

Outdoor treatment

In case of an overdose, should be washed with warm water.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

In clinical studies, the most unwanted effect is eye discomfort, corneal inflammation, eye irritation, with the frequency of 0.7% - 0.9% of patients with unwanted effects listed below according to the organs, frequency and severity, with conventional frequency: very common (≥ 1/10), commonly encountered
(≥ 1/100 to

Eyes

Not common: corneal inflammation, increased intraocular pressure, light sensitivity, pupils, eyelid collapse, eye pain, swelling of the eye, itchy eye, discomfort in the eyes, feeling of an object in the eyes, eye irritation, eye congestion, increased tears.

Not known: thin cornea, blurred vision.

immune system

Not common: hypersensitivity (at the eye or the whole body).

nervous system

Not known: headache.

Endocrine glands

Not known: Cushing syndrome, adrenal inhibition.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Smore Merap Meri Meri Small Music in the following cases:

Hypersensitivity to the substance or any ingredients of the drug.

Be cautious when using

only use to eye eye. Do not use for drinking or injecting.

Similar to antibiotics, using Scofi for a long time can lead to overworked growth of non -sensitive bacteria and fungi. If superinfection occurs, patients need to be treated appropriately.

Hypersensitivity to local aminoglycosides and cross -sensitivity with other aminoglycosides may occur. If there are signs of serious or hypersensitivity reactions, use drugs.

Serious reactions including neuropathy, ears and kidneys have been recorded when using naomycin systems systemic or on -site where the wound is open or damaged. Poisonous reactions on nerves and kidneys have also been recorded with body polymyxin bodies. Although these reactions have not been encountered when using eye drops, be careful when used simultaneously with aminoglycosides or polymyxin B system.

corticosteroids in scofi can reduce resistance and facilitate infections, grip, viruses that are not sensitive; Hide signs of clinical infections or signs of hypersensitivity reactions to scofi. Shy use drug if fungal infection occurs.

The prolonged use of prolonged corticosteroid eye drops can cause glaucoma and/or glaucom disease, with optic nerve damage, vision loss, narrowing the market, cataracts under the bag. The risk of glaucoma and cataract increases in patients inherently at high risk (for example, diabetics). Should regularly check the internal pressure when using this drug, especially important for children, due to the risk of glaucoma when using corticosteroid eye drops in children higher and appear earlier.

visual disorders may be encountered when using systemic and topical corticosteroids. If you experience symptoms such as blurred vision or other visual disorders, patients need to be evaluated, may include cataracts, glaucoma or rare diseases such as dark retinopathy that has been reported when using systemic or local corticosteroids.

In case of epidural perforation or cornea has been encountered in patients with epidural or cornea disease when using corticosteroid eye drops.

To avoid the risk of developing herpes in the eye, checking the eye with the slot regularly is very important.

The corticosteroid ingredient in Scofi can make the eye slowly recover in the event that the damaged eye of NSAID drugs used on the spot is also recorded slowly to recover to the eye. Simultaneous use of topical corticosteroids and local NSAIDs can increase the risk of eye damage recovery.

Cushing syndrome and/or adrenal suppression inhibit the absorption of dexamethasone in the eye at the common circulation may occur after continuous treatment lasting in high -risk patients, including children, patients treated with CYP3A4 inhibitors (ritonavir and cobicistat). In these cases, it is necessary to stop treating slowly.

Do not wear contact lenses during the treatment of eye infections. The benzalkonium chloride component in Scofi can cause eye irritation and discolor of soft contact menu. If continuing to wear during treatment, need to remove contacts before using Scofi and re -wear then at least 15 minutes.

The effect of the drug on the ability to drive and operate machinery

is like any other eye drops, temporary blurred vision and visual disorders that can affect the ability to drive and control machinery. If you are blurred after the drug, wait until you can see it clearly or operate machinery

Use drugs for women during pregnancy and lactation

fertility

There is no data on the effects of drugs on fertility in men or women.

Pregnant women

There are very little data on the use of drugs on pregnant women. Animal research with active components in scofi shows that there is toxicity on pregnant animals.

It is not recommended to use Scofi eye drops for pregnant women

breastfeeding women

Unknown dexamethasone, neomycin or polymyxin B when using small eye sugar is excreted in breast milk or not. Due to corticosteroids and aminoglycosides when using systemic sugars can excrete in breast milk, can not rule out the risk of children.

The decision to stop breastfeeding or not using Scofi eye drops should be considered based on the benefit of the drug for the mother and the risk of children.

Interactive drug

There is no study of drug interaction.

Concomitant use with steroids and nsaids on the spot may increase the risk of corneal recovery problems.

CYP3A4 inhibitors (including Ritonavir and COBICISTAT) may reduce dexamethasone excretion, increasing the adrenal inhibitor effects/Cushing syndrome. Should avoid simultaneous use with these drugs, unless the benefits are superior to the risk of increasing unwanted effects of corticosteroids. In these cases, patients need to be monitored the systemic effects of corticosteroids.

Simultaneous use and/or right after using aminoglycosides (neomycin) with drugs that are toxic to nerves, ears or kidneys systemic or other places can cause toxicity.

If using more than one eye drops, these drugs must be at least 5 minutes apart and eye ointment should be used final.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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