Scolanzo 30mg Laboratorios Liconsa Treatment Treatment of duodenal and stomach ulcers (2 blisters x 7 tablets)

Dosage form Box of 2 blisters x 7 tablets
Specifications Lansoprazole

Ingredient

Composition information	Content
Lansoprazole	30mg

Uses

indications

Scolanzo 30mg drugs are indicated in the following cases:

Treatment of duodenal ulcer, stomach ulcers, gastroesophageal reflux disease - acute esophagus. Treatment of maintenance after curing ulcerative esophagitis to reduce recurrence. (History of stomach ulcer) Must treat chronic diseases with NSAID.

Treatment of Zollinger - Ellison syndrome. Lansoprazol is related to structure and pharmacology with omeprazol.

Lansoprazols are not inversely linked to H+/K+ATPASE is an enzyme available on the cell surface of the stomach wall, so the Lansoprazol inhibits the final transportation of hydrogen ions into the stomach. Because the enzyme system H+/K+ATPASE is considered as the acid pump of the gastric mucosa, Lansoprazol is considered a proton pump inhibitor.

Lansoprazol inhibits the basic stomach acid secretion and is stimulated by any stimulant agents. Thanks to that, Lansoprazol is used for short -term treatment of stomach -duodenal ulcer and long -term treatment of hyperactive discharge of pathological digestive discharge (Zollinger -edison syndrome, multi -hormonal tumor, systemic nourishment).

The level of gastric acid secretion depends on the dose and treatment time, but the Lansoprazol inhibits acid secretion better than H2 receptor antagonists.

Combined with antibiotics (amoxicillin, clarithromycin), Lansoprazol can be effective in stomach inflammation caused by Helicobacter pylori.

Dynamic pharmacokinetics

absorption

Lansoprazol absorbs rapidly, the average maximum concentration is about 1.7 hours after drinking, with absolute bioavailability of over 80%.

In healthy, half -life in plasma is 1.5 (± 1.0) hours.

Maximum medication concentration and the area under the curve (AUC) decreased by about 50% if the drug was taken about 30 minutes after eating.

distribution

Lansoprazol binds to plasma proteins about 97%.

transformation

Lansoprazole metabolizes the liver thanks to the cytochrom P450 enzyme system to turn into two main metabolites: Sulfon Lansoprazol and Hydroxyl Lansoprazol.

Metabolic substances have very little or no effect against acid secretion.

Elimination

About 20% of the drug is excreted on bile and urine.

Elimination of Lansoprazole is prolonged in people with severe liver disease, but does not change in people with severe kidney failure. Therefore, the dose is needed for serious liver disease.

Before taking Scolanzo 30mg Laboratorios Liconsa Treatment Treatment of duodenal and stomach ulcers (2 blisters x 7 tablets)

How to use

Scolanzo 30mg drug used orally in the morning before meals.

Dosage

Dosage in case of duodenal ulcer:

Take 15-30mg, 1 time/day, use for 4 weeks or until the disease is cured.

Take 15-30 mg, 1 time/day, use for 4 weeks.

Take 30mg/1 ì/day.

Dosage in case of gastroesophageal reflux disease

Acute: Take 30 mg, 1 time/day for 4 weeks. Depending on the endoscopy results, it is possible to treat for 4 more weeks as directed by the doctor.

Maintain treatment after cure esophagitis ulceration to reduce recurrence: Adults take 15 mg/day. The level of safety and effectiveness has not been determined when the treatment remains for more than 1 year.

Dosage in case of coordination with antibiotics to kill Helicobacter pylori:

The common dose is 30 mg/time, 2 times/day in 7 days combined with 2 of the following antibiotics: Amoxicillin 1g, 2 times/day; Clarithromycin 500 mg, 2 times/day and Metronidazole 400mg, 2 times/day.

Common dose 60mg, 1 time/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Support treatment: The method of separation does not eliminate the drug.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Scolanzo 30mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Gastrointestinal tract: diarrhea, constipation, nausea, vomiting, abdominal pain, bloating and indigestion.

nerve: headache, dizziness, fatigue, drowsiness

Skin: Name and rash

Respiratory: Sore throat, rhinitis and cough.

Subclinical tests: Increased serum gaaster, liver enzyme, hematocrit, hemoglobin, uric acid and proteinuria.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Scolanzo 30mg contraindications in the following cases:

Sensitivity to Lansoprazol or other ingredients of the drug.

Pregnant women in the first 3 months, breastfeeding.

Severe renal failure (Creatinine clearance

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

Like other excreted inhibitors, Lansoprazols can change the intestinal bacteria due to reducing the volume and acidity of the gastric juice.

Treatment of acute stomach ulcers due to NSAID in patients who must continue using NSAID, Lansoprazol 30 mg/ day must be closely checked during 8 weeks of treatment.

The elderly: No need to adjust the dose of Lansoprazols in this age group, no increase in the rate of side effects in this age group.

Patients with failure: Be careful to use medication for patients with renal impairment (Creatinine clearance 30 - 70 ml/min), always follow the prescribed dose.

Patients with liver failure: The clearance of Lansoprazols slows down when using single -dose Lansoprazols for patients with liver failure, so treatment with Lansoprazol must be strictly controlled by the doctor and always weekly at the prescribed dose.

The ability to drive and operate machinery

The doctor may depend on the specific case that recommends whether or not recommend that patients take the drug when driving and operating machinery.

Pregnancy

There has been no notice of using Lansoprazols for pregnant women. It is unknown whether the drug passes through the fetus into the fetus. However, long -lasting use has caused cancer on both rats and male and female rats, so it should be avoided for pregnant women, at least in the first 3 months, but it is best not to be used in any stage during pregnancy.

breastfeeding period

lansoprazol and metabolites are excreted through milk in mice and will probably excrete through the mother's milk. Because the cancer effect of the drug on animals has been proven, should be avoided in nursing mothers.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Lansoprazol is metabolized by the cytochrom P450 enzyme system, so interact with other drugs metabolized by the same enzyme system. Therefore, Lansoprazol should not be used with other drugs that are also metabolized by Cytochrom P450.

There is no important clinical effect with Diazepam, Phenytoin, Theophylin, Prednisolon or Wafarin when used with Lansoprazol.

lansoprazole reduces the effect of ketoconazole, itraconazole and other drugs with acidic absorption.

Sucralfat slowed down and reduced the absorption of Lansoprazol (about 30%).

Storage

less than 25 ° C, in the original packaging to avoid desiccant.

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