Sedachor Haripharco fever, pain relief, flu, headache (50 blisters x 10 tablets)

Dosage form Box of 50 blisters x 10 tablets
Specifications Paracetamol, caffeine

Ingredient

Composition information	Content
Paracetamol	200mg
Caffeine	50mg

Uses

indications

Sedachor drug is indicated in the following cases:

Treatment of pain and fever from mild to medium, specifically as follows:

Analgesic in the following cases: headache, migraine, muscle pain, dysmenorrhea, sore throat, toothache, sinus pain, cold or flu, pain and fever after vaccination, pain after tooth extraction or after dental procedures ...

Pharmacy

Sedachor is an effective painkiller - antipyretic thanks to the combination of the effect of two active ingredients paracetamol and caffeine.

paracetamol is a metabolic substance that has the activity of phenacetin. Paracetamol relieves pain by inhibiting the activity of cyclooxygenase in the prostaglandin synthesis of the central nervous system. Due to the no effect of inhibiting peripheral prostaglandin, the drug has an important pharmacological properties of maintaining prostaglandin protected at the digestive tract, suitable for patients with a history of stomach ulcers, gastrointestinal bleeding. Paracetamol cools effectively due to the impact on the hypothalamus, causing vasodilation and increasing peripheral blood flow.

Cafeine has a slight stimulating effect on the central nervous system, enhances paracetamol analgesic effects and makes it easy for muscle activity, reducing fatigue. Sedachor is used for people who are operating trains and machinery because they contain caffeine stimulating central nerves, without causing drowsiness.

pharmacokinetic

absorption

Paracetamol is absorbed quickly and almost completely through the digestive tract, the peak in plasma is within 30 to 60 minutes after drinking with the dose of treatment. Cafeine is also quickly absorbed through the digestive tract, reaching the peak concentration in plasma after drinking for about 60 minutes.

Distribution

Paracetamol is quickly and evenly distributed in most body tissues, about 25% paracetamol in the blood linked to plasma proteins. Cafeine is widely distributed in the body, through the placenta and breast milk.

Metabolism and elimination

Paracetamol is metabolized in the liver and excreted in urine mainly in the form of glucuronic and sulphat metabolites - less than 5% paracetamol is excreted in a constant form, the sale time in plasma is about 1.25 - 3 hours, which can last longer in people with liver damage. Cafeine is metabolized almost entirely in the liver with Demethyl reaction and oxidation, excreted mainly through urine in the form of metabolic, the sale time is about 3-7 hours.

Before taking Sedachor Haripharco fever, pain relief, flu, headache (50 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults and children over 12 years old

Take 2 - 4 capsules/time, if necessary, you can drink again every 4-6 hours but not more than 20 tablets a day.

Children 9 - 12 years old

Take 1-2 tablets/time, if necessary, you can drink again every 4 - 6 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? The liver necrosis depends on the dose is the most serious toxic effect due to overdose and may cause death.

Expressions of overdose

Nausea, vomiting, abdominal pain usually occur within 2-3 hours after taking the poisonous dose of the drug. More severe, can cause blood methemoglobin leading to purple blue, mucosa and nails, consciousness disorders, impaired liver function, liver necrosis.

How to handle

Early diagnosis is important in the treatment of paracetamol overdose. When severe toxicity is important, there is a positive supportive treatment. Gastric lavage in any case, preferably within 4 hours after drinking. The main detoxification is the use of sulfhydryl compounds. N-acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol.

Treatment with n-acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N-acetylcystein solution with water or drinks without alcohol to get a 5% solution and drink for 1 hour after mixing. Give N-acetylcystein with the first dose of 140mg/kg body weight, then 17 more doses, each dose of 70mg/kg body weight every 4 hours apart. Without Aceylcystein, methionine can be used, in addition to activated carbon or salt -bleaching, because it has the ability to reduce the absorption of paracetamol.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Sedachor, you may experience unwanted effects (ADR).

Less (1/1000

DA: Ban Da.

stomach - intestines: nausea, vomiting.

Hematology: neutropenia, all bloody hemoglobin, leukopenia, anemia. kidney: Kidney disease, kidney toxicity when abused for a long time.

Rare (ADR

Immune: Hypersensitivity reaction.

liver: can cause liver failure (due to liver cancellation) when using high, prolonged doses.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sedachor drugs contraindicated in the following cases:

People who are sensitive to paracetamol, caffeine or any ingredients of the drug.

Patients with glucose-6-phosphate dehydrogenase (G6PD).

Precautions when using

Use medication carefully with chronic anemia.

Be cautious, avoid drinking while taking this medication.

Use carefully with people with impaired liver or kidney function.

Paracetamol can cause serious side effects on the skin, although the incidence is not high, so the doctor needs to warn the patient about serious skin reaction signs such as Steven-Jonhson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pus syndrome (AGEP) when taking this drug.

The ability to drive and operate machinery

Sedachor can be used for those who are operating train and machinery because they contain caffeine stimulating central nerves, not causing sleepiness.

Pregnancy

has not determined the safety of the drug used during pregnancy related to unwanted effects that may be available to the development of the fetus. Medication should only be used in pregnant people when really necessary.

Breastfeeding period

Research in mothers taking drugs after breastfeeding, which has not been determined in any risk in breastfed babies.

Medicinal interaction

Long -doses of high -dose Paracetamol increases the anticoagulant effect of COUMARIN and conducting indandion.

Concentrated with phenothiazine can cause serious antipyretic.

Out of alcohol too much and long may increase the risk of toxic to the liver of the drug.

Anti -seizure drugs (Phenytoin, Barbiturat, Carbamazepin) cause enzyme induction in the liver microsom, which can increase the toxicity of paracetamol liver toxicity due to increased drug conversion into toxic substances to the liver.

Concentrated with Isoniazid may increase the risk of damaging the liver of the drug.

Storage

In a dry place, avoid light, temperatures below 30 ° C.

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