Sededon NN 20 Meyer supports anti -inflammatory and immunosuppressive (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Prednisolone

Ingredient

Composition information	Content
Prednisolone	20mg

Uses

indications

Sedon NN 20 drugs are indicated for short -term or long -term treatments such as glucocorticoid therapy, including:

allergies: cases of severe allergies, not responding to conventional treatment; serum disease; The hypersensitivity reactions of the drug. Pemphigus. Platelets.

Nephrotic syndrome. Some of these characteristics produce the physiological effects of endogenous glucocorticoids. The effects of Prednisolon are due to the characteristic of glucocorticoids including: increasing glycogen synthesis, increasing glycogen storage in the liver, inhibiting the use of glucose, antagonistic antagonism of insulin, increasing protein catabolism leads to negative nitrogen balance, redistribution in the body, increasing lipid cancellation, increasing urination of urination in urine. exchange), reduce calcium absorption in the intestine and increase the excretion of calcium through the kidneys. Prednisolon reduces acid and lymphocytes but stimulates red blood cells in the bone marrow and neutrophils. In physiological doses, corticosteroids are used to replace endogenous hormones.

Other effects of glucocorticoids are only available when using higher doses of treatment than physiological doses (pharmacological doses). In these doses, the drug is used for both treatment and diagnostic purposes, due to the ability to inhibit the normal excretion of adrenal hormones. In pharmacius doses, glucocorticoid has anti -inflammatory, immunosuppressive and effect on blood and lymphatic systems, used for temporary treatment in many different diseases.

Prednisolon inhibits inflammation (edema, fibrin deposits, capillary dilatation, white blood cell movement and macronal cavity into the inflammatory foci) and the later stage of healing wound scars (capillary proliferation, collagen deposition, scar formation). Anti -inflammatory mechanism: Stabilizing the lysosom membrane of leukemia, preventing the release of acid hydrolase destroyed from leukocytes, inhibiting the concentration of macrophages at the inflammatory drive, reducing white blood cell adhesion with capillary endothelium, reducing the permeability and formation of edema, reducing the component, antagonistic with the activity of histamine and releasing kinine, reducing the proliferation of collagen and formation of collagen and shapes in the stage of the fiber, and the scars in the stage and the scarred in the stage of the mechanism and the scarred in other mechanisms, the scars of other mechanisms are in the stage of the stage and the scarred in the stage Know well.

Prednisolon inhibits the immune system due to reducing the activity and volume of the lymphatic system, reducing lymphocytes, immune globulin reductions and complementary concentrations, reducing immune complexes through membranes and can be by reducing tissue reactions to antigen-meter interactions.

Prednisolon can stimulate the excretion of different components of gastric juice. Prednisolon has weak mineralocorticoid activity, increases sodium retention and loss of potassium in the cell, can lead to sodium stagnation and hypertension.

Glucocorticoid therapy does not cure the disease and is rarely indicated as the first method in treatment, usually for supportive treatment with other specified therapies.

Effect of oral Prednisolon compared to other glucocorticoids: 5 mg Prednisolon has the same effect as 4 mg methylprednisolon or triamcinolon, 0.75 mg dexamethasone, 0.6 mg betamethasone and 20 mg hydrocortison.

Dynamic pharmacokinetics

Prednisolon is easily absorbed from the gastrointestinal tract, bioavailability depends on the soluble concentration if taking the tablet. Peak concentration in plasma reaches 1-2 hours after drinking. Prednisolon binds to protein about 65 - 91%, reduced in the elderly. The distribution of the drug is 0.22 - 0.7 liters/kg.

Prednisolon is metabolized mainly in the liver, but is also metabolized in most tissues, into non -activity metabolites. Elimination mainly in urine in the form of free metabolites or sulfate and complex glucuronid. Prednisolon waste time is about 3.6 hours. Effect time 18 - 36 hours.

Before taking Sededon NN 20 Meyer supports anti -inflammatory and immunosuppressive (3 blisters x 10 tablets)

How to use

oral oral medications, dispersed in water before drinking.

Daily dose should be used in the morning after meals. When needed for Prednisolon for a long time, should take Japanese medicine, only once in the morning, after treatment must stop the drug gradually step by step.

Dosage

adults:

Common dose: 5 - 60 mg/day.

scattered sclerosis: 200 mg/day for 1 week, then 80mg used for daily for 1 month.

Rheumatoid arthritis: Starting dose 5 - 7.5 mg/day, adjusting the dose when necessary.

Children:

Genital bronchial asthma: 1 - 2 mg/kg/day, divided into 1-2 times (maximum 60 mg/day), for 3-10 days. Prolonged treatment: 0.25 - 2 mg/kg/day, drink once a day in the morning or daily when needed to control asthma.

Anti -inflammatory and immunosuppressive inhibition: 0.1 - 2 mg/kg/day, divided into 1-4 times.

Nephrotic syndrome: Starting 2 mg/kg/day or 60 mg/m2/day (maximum 80mg/day), divided into 1-3 times, until urine is no longer protein for 3 consecutive days or for 4-6 weeks. Then use the maintenance dose 1 - 2 mg/kg or 40 mg/m2, used on the morning in the morning for 4 weeks.

Maintain long -term if regular recurrence: 0.5 - 1.0 mg/kg, used for daily for 3-6 months.

Elderly: Using the lowest dose effectively.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms of overdose:

Pro -prolonged Prednisolon can cause mental symptoms, round faces, abnormal fat deposits, stasis, eat, gain weight, hair, acne, skin pattern, bruising, sweating, skin pigmentation, dry skin, thinning hair, hypertension, tachycardia, thrombosis, reducing resistance to infection, nitrogen bone, nitrogen, nitrogen, weakness, weakness Menopause symptoms are worse, neuropathy, osteoporosis, fracture, stomach - duodenal ulcer, reduced glucose tolerance, hypokalemia and adrenal insufficiency.

Big liver and bloating have met in children.

Overdose:

Extract treatment: gastric lavage or instant vomiting, then symptomatic or supportive treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

The most common effects occur most when using high -dose and long -doses of Prednisolon. Prednisolon inhibits prostaglandin synthesis and thus losing the effect of prostaglandin on the digestive tract means losing the effect of inhibiting gastric acid secretion and protecting the stomach lining. Many ADRs are related to this effect of glucocorticoid.

Common, ADR> 1/100:

Central nervous system: Insomnia, nervousness is easily agitated. Orange.

Central nervous system: dizziness, convulsions, mental disorders, fake brain, headache, mood change, delirium, hallucinations, refreshment. Glucose, Potassium -reduced, alkaline infection, amenorrhea, sodium and water, hyperglycemia Corticosteroid dose too fast after prolonged treatment can lead to adrenal anemia, hypotension and death. "Detox syndrome" may occur including joint pain, conjunctivitis, fever, weight loss, muscle pain, itchy nodules and rhinitis.

Instructions on how to handle ADR:

In acute indications, except leukemia and anaphylaxis, glucocorticoids should be used in the lowest doses and in the shortest time of clinical effect.

After a long -term treatment with glucocorticoid, there is a possibility of inhibiting the hypothalamus - pituitary - adrenal gland, so it is imperative to reduce the dose of glucocorticoids step by step, instead of sudden stopping. Prednisolon's reduction process may be applied: every 3 to 7 days decrease 2.5 - 5 mg, until the physiological dose of Prednisolon is approximately 5 mg. If the disease is worse when it is reduced, increasing the dose of prednisolon and then reducing the prednisolon dose slowly.

Apply continuous treatment to avoid drugs with pharmacological effects. Using a single dose of the day causes less ADR than the doses of the day, and Japanese insulation is a good measure to minimize the inhibition of adrenal glands and minimize other ADRs. In Japanese therapy, every two days use a single dose, in the morning.

Monitoring and periodic assessment of osteoporosis parameters, hemorrhage, glucose tolerance, eye effects and blood pressure.

Preventive gastric and duodenal ulcer prophylaxis with Histamine H, or proton pump inhibitors when taking high doses of corticosteroids.

All long -term patients with glucocorticoids need additional calcitonin, calcitriol and supplementing calcium to prevent osteoporosis.

People who are likely to be inhibited by glucocorticoids should be warned about the likelihood of infection.

Patients who are about to have surgery may have to use glucocorticoid supplements because of the normal response to stress that has been reduced due to the inhibition of hypothalar axis - pituitary - adrenal gland.

Notice immediately to the doctor or pharmacist the harmful reactions encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Sededon nn 20 drug contraindicated in the following cases:

Hypersensitivity to Prednisolon or any ingredients of the drug.

Be cautious when using

be careful when using corticosteroids, including prednisolon. Can prescribe but need regular monitoring in the following patients:

Diabetes (including family history). There is a history of mental disorders caused by corticosteroids. Only used when combined with anti -tuberculosis drugs.

Chickenpox: Chickenpox can be fatal in patients with immunodeficiency. Patients (or parents of children) have no history of disease, should avoid exposure to chickenpox or herpes zoster, if exposed, they need to immediately medical facilities to be monitored and cared for. Passive vaccination with Varicella-Zoster (VZIG) is necessary for patients without immunity but is being treated with systemic corticosteroids or for those who have used the drug within the previous 3 months. Varicella-Zoster vaccinated within 10 days from the date of contact with chickenpox. If diagnosed with chickenpox, the patient must be taken care of specialties and emergency treatment. Corticosteroids should not be stopped and the dose may need to be increased.

Measles: Patients with Prednisolon should avoid contact with measles and should be consulted immediately if exposed. Preventive treatment can be treated with globulin.

Inhibition of inflammatory reactions and immune function increases the likelihood of infection and severity.

The effect of corticosteroids can increase in thyroid patients, people with chronic liver disease with impaired liver function.

Do not live a living vaccine for people with immunodeficiency. Antibody reactions to other vaccines may be reduced.

The adrenal glands grow and can last for many years after the drug stopped.

Stop drugs: In patients who have taken the body corticosteroid doses (about 7.5 mg of prednisolon or equivalent) for more than 3 weeks, do not stop the drug suddenly. When stopping the drug must be cautious and slowly reduced. Is it necessary to monitor if the disease relapses when the dose is reduced or not.

The treatment of systemic corticosteroids lasts up to 3 weeks is suitable if the disease does not recur.

Of the following patient groups, body corticosteroid treatment should be stopped:

Patients who have been treated for long corticosteroids, especially if used for more than 3 weeks. Evening. Gluten allergy.

The effect of the drug on the ability to drive and operate machinery

If sleep is not enough, the possibility of lack of alertness can increase when taking the drug. Patients need to be guaranteed that they are not affected before driving or operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women:

Prednisolon passes the placenta and can be dangerous to the fetus when used for pregnant women. Animal studies and people suggest that using corticosteroids in the first 3 months of pregnancy increases the risk of lip chipping, cleft palate, reducing pregnancy growth in the uterus and reducing weight at birth. Using corticosteroids for mothers during pregnancy can cause adrenal insects in newborns.

If you use Prednisolon during pregnancy or began to get pregnant, you must be taking medication, notice to patients with danger to the fetus. In general, using corticosteroids in pregnant women requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding women:

Prednisolon secretes breast milk with a concentration of milk in 5-25% of the mother serum concentration, equal to 0.14% of the mother's daily dose. Be careful when using Prednisolon for nursing mothers. Mothers taking high doses of corticosteroids for a long time can affect the growth and development of breastfed babies and affect endogenous corticosteroid production. Must consider the benefits/ risks of both mother and child. If required to use Prednisolon for breastfeeding people, the lowest dose must be used enough to achieve clinical effect.

Interactive drug

antacids can reduce Prednisolon absorption if high doses. Do not use anti -keloid drugs at the same time as the day with prednisolon.

Rifampicin, rifabutin, carbamazepin, phenobarbital, phenytoin, primidon, carbimazol and aminoglutethimids increase corticosteroid metabolism and reduce treatment effect. Therefore, need to adjust the dose of Prednisolon accordingly.

corticosteroid increases the effects of hypoglycemic drugs (including insulin), antihypertensive drugs and diuretics.

Increasing the potassium effect of acetazolamid, circulatory diuretics, thiazid diuretics, Beta -2 transportation drugs, theophylin and carbenoxolon.

Increases the effectiveness of coumarin anticoagulants when used simultaneously with corticosteroids and must closely monitor Inr or prothrombin time to avoid spontaneous bleeding.

ciclosporin increases the concentration of prednisolon in plasma.

Increased lodging of salicylate in the kidneys caused by corticosteroids and stopping the drug can lead to Salicylate poisoning.

Avoid simultaneous use of prednisolon with nonsteroidal anti -inflammatory drugs as it can cause stomach ulcers.

Be cautious when combining aspirin with glucocorticoid in patients with hypotension. Simultaneous use of aspirin and prednisolon may increase the risk of digestive ulcers and subcutaneous aspirin levels. Antihabulosis: Avoid using Amphotericin B as a hemorrhagic risk of hypokalemia. Ketoconazole reduces the metabolism and clearance of methylprednisolon, which can also happen to prednisolon.

Mifepriston reduces the effect of corticosteroids for 3-4 days after use.

methotrexate can reduce steroid metabolism. There is evidence that the toxicity of methotrexate increases.

corticosteroid inhibits Etoposid metabolism in in vitro, increasing both the effect and toxicity of Etoposid. Need closely monitoring. Corticosteroids should not be used simultaneously with retinoid and tetracycline due to increased intracranial pressure.

estrogen and progestogen increase corticosteroid levels in plasma.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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