Seocem Capsule Guju Pharma Treatment of osteoarthritis symptoms (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Diacerhein

Ingredient

Composition information	Content
Diacerhein	50mg

Uses

Indications

Seocem drugs are indicated in the following cases:

Treatment of symptoms of osteoarthritis in the groin or knee. Anti -osteoarthritis properties and cartilage stimulation have been shown on in vitro and on the animal model. Diacerhein and Rhein inhibit the production of Interleukin - 1 Beta by mononoculatocurrendic white blood cells in humans and inhibit the effects of cytokine on Vitro cartilage cells. The drug shows the effect of protecting cartilage on artificial cartilage culture and reducing the level of damage to the epidemic, bone and cartilage in osteoarthritis.

They also have some inhibitory effects on the activity and movement of leukemia, which contributes to the weak anti -inflammatory effect of the drug. Studies have shown that Diacerhein does not inhibit the synthesis of prostaglandin, thromboxane or leukotriene but in fact can stimulate the synthesis of prostaglandin, especially PGF - 2 alpha, a prostaglandin that protects the stomach lining cells. Diacerhein does not change the activity of platelet cyclooxygenase or kidney, so it can be tolerated in patients with renal function depending on prostaglandin.

pharmacokinetic

absorption

The oral bioavailability of Diacerhein is about 35 - 56%. Take the medicine with food that slowly reaches the peak concentration of 2.4 - 5.2 hours (p

Distribution

Links to the total protein of Rhein about 99% with plasma albumin and less linked with lipoprotein and gamma - Immunoglobulin.

Metabolism

After oral use, Diacerhein is metabolized mainly in the liver into Rhein, which is an active metabolic substance that has reduced the acetyl group, before going to the common circulation. The metabolites are mainly active, Rhein Glucuronide and Rhein Sulfate with a half -life from 7 to 8 hours.

Elimination

Diacerhein's excretion in the form of metabolites is about 35 - 60%, with about 20% in the form of free rhein and 80% in the form of conjugated rhein.

Before taking Seocem Capsule Guju Pharma Treatment of osteoarthritis symptoms (10 blisters x 10 tablets)

How to use

SEOCEM medicine is taken orally. The drug is best absorbed when taken at the same time.

Dosage

Initial, take 1 tablet 1 time/day in the evening for the first 2 to 4 weeks, then take 1 tablet 2 times/day.

Common dose: 1 capsule 2 times/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Symptomatic treatment with electrolyte imbalance correction if deemed necessary.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using SEOCEM, you may experience unwanted effects (ADR).

The most unwanted effect is the most common report is to increase the intestinal peristalsis time (diarrhea in 37% of patients). Some cases of abdominal pain have been described. To minimize these adverse effects, the dose adjustment is allowed at the beginning of the treatment (2 to 4 weeks).

Other adultery effects are recorded as urine discoloration in 14.4% of cases and individual cases of hypotension, liver toxicity leading to acute hepatitis and death epidermal necrosis (lyell syndrome).

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SEOCEM drugs contraindicated in the following cases:

Hypersensitivity to diacerhein or any ingredients of the drug.

Inflammation (ulcerative ulcer, Crohn disease), bowel obstruction.

Precautions when using

should be started with a dose of 1 tablet in the evening for the first 2 to 4 weeks because the initial medication may increase intestinal motility.

Should be treated continuously for at least 6 months. Clinical trials have shown that this drug can be used for 2 years without any serious adverse effects.

As with other long -term therapies, it is recommended to monitor the test indicators, including liver enzymes, every 8 months.

Avoid simultaneous use with laxatives.

kidney failure

In patients with average to severe to severe renal failure, there is a significant increase in AUC and reducing total clearance compared to healthy adults. In case of severe renal failure (clearing of Creatinine 10 - 27 ml/minute) significantly reduces Rhein clearance in the kidneys, so it is necessary to reduce Diacerhein by 50% in severe renal impaired patients.

Hepatic failure

There is no significant difference in rhein pharmacokinetic parameters in plasma or urine between patients with liver impairment and healthy volunteers. However, cirrhosis can affect the accumulation of drugs after multiple doses, so clinical monitoring should be closely monitored in patients with liver failure.

Elderly

Daily dose exceeds 100 mg to ensure close clinical monitoring in elderly patients.

Children

Diacerhein's dynamic pharmacokinetics have not been studied in the population group of children, so it should not be used on this object group.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

should not use diacerhein for pregnant women.

There is no clinical data on the use of diacerhein for pregnant women. Unknown potential risks when taking this drug in pregnant women.

Breastfeeding period

Should not be used for breastfeeding women because of Diacerhein's pharmacokinetics that have not been studied in breastfeeding women.

Drug interaction

Clinical studies have shown that there is no interaction with other drugs such as Warfarin, Tolbutamide, Aspirin, Chlorpromazine, Indomethacin.

Storage

Store under 30ºC, avoid light.

To be out of reach of children.

Other drugs

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