Seretide Evohaler DC 50/250 GSK Seretide Dosage Treatment Treatment of Bronchial Hen, Chronic Pulmonary Block (60 Doses)

Seretide Accuhaler 50/250 is indicated in the treatment of gas congestion and reduced drama in patients with chronic obstructive pulmonary disease (COPD) and has been shown to reduce the mortality rate for all causes.

Pharmacokology

salmeterol

Salmeterol is the beta 2 sympathetic receptor owner who has a selective and prolonged effect (12 hours) with a long chain structure that is connected to the exterior (EXO-Site) of receptors.

Salmeterol's pharmacological characteristics bring more efficient protection for bronchospasm of histamine and create longer bronchodilator effects, lasting it is 12 hours, compared to the Beta 2 shipping owner with a short -term effect according to the proposed dose.

fluticasone propionate

At the recommended dose, Fluticasone Propionate inhaled inhalation has a strong anti -inflammatory activity of a powerful glucocorticoid in the lungs, reduces symptoms and drama of asthma, which has no unwanted effects to be observed when using body corticosteroids.

pharmacokinetics

salmeterol

absorption:

absorption:

To close Accuhaler, put your thumb on the groove, push it back to your friend.

When you close Accuhaler, it also calls for "separation". Need to automatically push back to its original position and the drug is reloaded. Your Accuhaler is ready for the next use.

Dosage

asthma (obstruction of a recovery gas path):

Adults and teenagers aged 12 years and older:

A dose of inhalation (50 micrograms salmeterol and 250 microgram fluticasone propionate), 2 times/day or a dose of inhalation (50 microgram salmeterol and 500 microgram fluticasone propionate), 2 times/day. The maximum dosage recommends for adults and children over 12 years old is 500/50, 2 times/day.

Chronic obstructive pulmonary disease (COPD):

The recommended dose for adults is a 50/250 microgram to 50/500 microgram salmeterol/Fluticasone Propionate X twice a day. At the treatment dose of 50/500 microgram x 2 times/day.

Special patient group:

No dose adjustment for elderly patients or patients with renal impairment or liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

Inhalation of the acute fluticasone propionate can lead to temporary inhibition of the hypothalamus shaft - pituitary - adrenal gland. Often there is no need for emergency treatment due to the adrenal gland function returning to normal after a few days.

If inhaling the Accuhaler seretide with a higher dosage than the approved dose for a long time can significantly inhibit the adrenal gland shell. Situations that can cause acute adrenal attacks include trauma, surgery, bacterial infection and any rapid decrease in the inhalation of Fluticasone Propionate.

Treatment:

There is no specific treatment for the overdose of Salmeterol and Fluticasone Propionate. If an overdose occurs, patients should be treated with appropriate monitoring if needed.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Notify the doctor with unwanted effects when taking the drug.

Caution when using

worsening and exacerbations:

Seretide Accuhaler 50/250 should not be started in patients who are in the stage of deteriorating quickly or exacerbations of asthma or COPD are at risk of life -threatening.

Seretide Accuhaler 50/250 is not a drug used to reduce acute symptoms, but in this case, a fast and short -acting bronchodilator (for example, Salbutamol). It is recommended that patients always have symptoms of symptoms.

The on -site effect of inhaled corticosteroids:

The development of local infections at the mouth and throat caused by Candida Albicans occurred in patients treated with Seretide Accuhaler 50/250. When such an infection is developed, it is necessary to be treated with anti -fungal therapy (oral) or appropriate local treatment while treating with Seretide Accuhaler 50/250 is still continued or stopped.

pneumonia:

Doctors should be wary of the likelihood of progressive pneumonia in COPD patients because of the clinical characteristics of pneumonia and COPD's plays often overlap.

Patient transfer from body corticosteroid treatment:

Because of the ability to decline in adrenal response, patients transferred from oral steroids to Fluticasone Propionate inhaled form, should be treated with special care and regular monitoring of the adrenal skin function regularly.

According to the inhalation of inhaled Fluticasone Propionate, stopping the whole body treatment should be done slowly and encouraging patients to carry a warning card about steroids indicating that it may need additional treatment during stress.

Increase the adrenal function and inhibit the adrenal glands:

There may be effects of systemic corticosteroids such as increased adrenal function and adrenal inhibition (including adrenal crisis) may appear in a small number of patients sensitive to these effects. If such effects occur, Seretide Accuhaler 50/250 should be slowly reduced, in accordance with the accepted process of reducing the dose of systemic corticosteroids, and other treatments to control asthma symptoms should be considered.

paradoxical bronchospasm and upper respiratory symptoms:

paradoxical bronchospasm can occur with wheezing immediately after taking the drug. In this case, patients should be treated immediately with a quick and short -acting bronchodilator. Should stop using Salmeterol-FP Accuhaler immediately, patients need to be evaluated and replaced if necessary.

Instant hypersensitivity reactions:

Instant hypersensitivity reactions (for example, urticaria, angioedema, rash, bronchospasm, hypotension), including anaphylactic reaction, may occur after using the Accuhaler Seretide 50/250. For patients with severe allergy to milk protein should not use Seretide Accuhaler 50/250.

Effects on cardiovascular and central nervous system:

Seretide Accuhaler 50/250 should be used cautiously in patients with cardiovascular disorders, especially coronary artery, arrhythmia, and hypertension.Bone mineral density (Bone Mineral Density (BMD):

Patients with high risk factors reduce bone density, such as long -term immobility, family history of osteoporosis, menopause, use of cigarettes, high age, poor nutrition, or regular use of drugs that can reduce bone mass (for example, anticonvulsants, oral corticosteroids) need to be monitored and treated with established care standards. If the BMD is significantly reduced, the Accuhaler Seretide 50/250 is still considered an important drug to treat the patient's COPD, using the drug to treat or prevent osteoporosis, so it is clearly considered.

Effect on growth:

Corticosteroid inhaled inhalation may cause a reduction in children's growth when used for children. It is necessary to monitor the growth of pediatric patients using Seretide Accuhaler 50/250 regularly (for example, through height measurement). Need to adjust the dose of each patient to the lowest dose effectively control symptoms.

Obmtrophy and cataract:

other warnings and caution:

Sudden and increasing deterioration of asthma control is life -threatening and patients need to be examined by a doctor. Corticosteroid dose should be considered. Patients should also be examined again when the seretide Accuhaler 50/250 dose is using asthma.

Do not stop using Seretide Accuhaler 50/250 suddenly in asthma patients due to the risk of drama, should reduce the dose slowly under the doctor's supervision. For patients with COPD, stop treatment may cause symptoms and should be monitored by a doctor.

Should use Seretide Accuhaler 50/250 cautious in patients with toxic thyroid poisoning.

Should be carefully used Seretide Accuhaler 50/250 in patients who can easily lower serum potassium levels.

Be cautious when prescribing patients with a history of diabetes.

The ability to drive and operate machinery

drivers and machinery operators should pay attention to the unwanted effects of the drug, including headache, cramps, joint pain, fractures due to injury, muscle pain. In addition, the drug may also have unwanted effects such as tremor, anxiety, sleep disorders, difficulty worshiping, face and mouth edema, bronchospasm, bronchial drum, tachycardia, atrial fibrillation and angina.

Pregnancy

should only consider using seretide for pregnant women if the benefit to mothers is greater than any risk that may occur for the fetus.

The period of breastfeeding

should only consider using the drug during breastfeeding if the benefit gives the mother superior to any risk that may have for the child.

Drug interaction

should avoid using selective beta blockers and not selective in patients unless there is a mandatory reason.

Less in clinical drug interactions via Fluticasone Propionate intermediaries.

Avoid simultaneously using Fluticasone Propionate and Ritonavir unless the benefits are superior to the risk of corticosteroid side effects.

Be cautious when using strongly strong inhibitors of Cytochrome P450 3A4 (such as ketoconazole) due to the ability to increase systemic exposure to Fluticasone Propionate.

Simultaneous use ketoconazole and Serevent (Salmeterol) increases the Salmeterol level in plasma (cmax increases 1.4 times and AUC increases 15 times) and this also causes a long QTC.

Be cautious when combining strong CYP 3A4 inhibitors such as Ketoconazole, the body causes an increase in exposure to Seretide Accuhaler 50/250.