Seroquel XR 200mg Astrazeneca medicine for mental disorders (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Quetiapine

Ingredient

Composition information	Content
Quetiapine	200mg

Uses

indications

Seroquel XR is indicated in the following cases:

Senocious mental illness.

Treatment of bipolar disorders:

Treatment of rituals from medium to severe in bipolar disorder. Mainly (MDD) does not meet well with antidepressants.

Treatment of disorder Axious whole (GAD).

Pharmacokology

Quetiapin is an anti -psychotic drug that is not typical. Quetiapin and metabolites are active in human plasma - Norquetiapin has an affinity for the serotonin receptor (5HT2) in the brain and with the dopamine receptor D1 and D2.

Dynamic pharmacokinetics

The drug is well absorbed when taken. The peak concentration is about 6 hours after drinking. Quetiapin binds to plasma proteins about 83%. Quetiapin is completely metabolized by the liver and CYP 3A4 is the main enzyme responsible for metabolism. About 73% of the drug is excreted in urine and 21% in feces.

Before taking Seroquel XR 200mg Astrazeneca medicine for mental disorders (3 blisters x 10 tablets)

How to use

Seroquel XR is indicated for a dose once a day, not taking medicine with food (minimum medication 1 hour before meals). Should swallow the whole pill, do not double, chew or crush.

Dosage

Adults:

Treatment of schizophrenic mental illness and average to severe mental attacks in bipolar disorders:

The initial treatment dose is 300 mg (dated 1), 600 mg (daily 2). The daily recommended dose is 600 mg, however, if clinically proven, the dose may increase to 800 mg/day. The dose should be adjusted in an effective dose range from 400 mg to 800 mg/day depending on the clinical response and the ability to tolerate the patient. No dose adjustment when treated for mental patients with schizophrenia.

Treatment of major depression in bipolar disorders:

Should drink before going to bed. The total daily dose in the first 4 days of treatment is 50 mg (daily 1), 100 mg (dated 2), 200 mg (dated 3) and 300 mg (dated 4). The recommended daily dose is 300 mg. Some individual patients may have more benefits when using the 600 mg dose.

Preventing the recurrence of bipolar disorders:

Adjust the dose depending on the response and tolerance within 300 mg - 800 mg/day.

Treatment of support for major depression in depression disorders:

Should drink before going to bed. The starting dose is 50 mg for dates 1 and 2, and 150 mg for 3 and 4 days. The need to increase the dose from 150 mg/day to 300 mg/day should be based on the results of each patient's evaluation.

Treatment of whole anxiety disorders (GAD):

start at a dose of 50 mg for 1 and 2, and increase to 150 mg for 3 and 4 days. Adjust the dose according to the recommended dose range from 50 mg to 150 mg/day. Based on assessment in each patient, if the dose is needed to 300 mg/day, it is not advisable to increase before the 22nd of treatment.

Children: It is not recommended to use Seroquel XR for children and minors under 18 years of age because there is no data to support the use of drugs for groups of patients at this age.

Renal failure: There is no need to adjust the dose for patients with renal failure

Liver failure: Quetiapin is metabolized in the liver. Caution should be used in patients with liver failure, especially when starting therapy, it is recommended to start at a dose of 50 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of severe poisoning, special care measures should be taken, setting up airway maintenance, ensuring ventilation and adequate oxygen supply, monitoring and cardiovascular support. It is possible to appoint a stomach within 1 hour when taking the medication if possible. Can consider using activated carbon.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Seroquel XR , you may experience unwanted effects (ADR).

Common, very common ADR> 1/100:

Hematology: Hemoglobin reduction, leukopenia, eosinophilia;

Endocrine: increased blood prolactin levels;

Metabolism, nutrition: Increased serum triglycerides, total cholesterol, HDL cholesterol, weight gain;

Mental: abnormal dreams, nightmares, suicide or suicide behavior; Neurological: dizziness, drowsiness, headache , Symptoms of the pagoda; Cardiovascular: tachycardia, suspense, Hypotension can stand;

Eye: blurred vision;

Respiratory: Difficulty;

digestive: constipation, indigestion , vomiting;

Overview: External edema, mild weakness, stimulation, fever.

Uncommon, rare, very rare ADR

Hematology: loss of granulocytes;

immune: hypersensitivity, anaphylactic reaction; Endocrine: Reduce thyroid function, increase the inappropriate anti -diuretic hormone; Metabolism: metabolic syndrome, diabetes, worse diabetes, hypoglycemia;

Skin and subcutaneous tissue: Evaluation, Stevens - Johnson syndrome;

Kidney and urinary: Urinary retention;

musculoskeletal:

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Seroquel XR contraindicated in the following cases:

Patients with hypersensitivity to any ingredients of the drug.

Used in combination with Cytochrom P450 3A4 inhibitors, such as HIV-Protease inhibitors, Azol, erythromycin, Clarithromycin and Nefazodon.

Be cautious when used

Patients who are recorded with a history of suicidal events or patients who are more likely to have suicide thoughts before starting treatment should be closely monitored during treatment.

The drug is at risk of getting worse patients' metabolism such as changing weight, blood glucose and lipid, so the patient's metabolic parameters should be evaluated at the beginning of treatment and monitor the change of this parameter during treatment.

Treatment with quetiapin can cause drowsiness and related symptoms such as vague.

Treatment with quetiapin can cause hypotension and vertical posture. Quetiapin should be used cautiously in patients with cardiovascular disease, cerebrovascular disease or other traits that can cause hypotension.

Sleep apnea syndrome has been recorded in patients using Quetiapin. Be cautious when using Quetiapin in patients who are simultaneously taking antidepressants on the central nervous system and people with a history or a risk of sleep apnea syndrome such as overweight/obesity or men.

Malignant syndrome caused by sedatives is related to the treatment of anti -psychotic drugs, including Quetiapin. In this case, the drug should be discontinued and has appropriate treatment.

Neutral leukemia and serious grain leukocytes have been recorded in clinical trials on Quetiapin. It is recommended that patients report as soon as the signs/symptoms of granulocytes or infections (such as fever, weakness, coma or sore throat) during the treatment process with Seroquel.

Be cautious when using quetiapin in patients being diagnosed or has a history of urinary retention, prostate hypertrophy or narrow angle glaucoma.

After the drug circulates on the market, extending the QT range has been recorded when using Quetiapin at the dose of treatment.

Difficult to swallow has been recorded when using Quetiapin and should be cautious when used in patients at risk of inhaled pneumonia.

Cases of venous embolism caused by thrombosis (VTE) have been reported when using psychotic drugs.

Pancreatitis has been recorded in clinical trials and after the drug circulates in the market.

The ability to drive and operate machinery

Due to the main impact on the central nervous system, Quetiapin can affect activities that need mental alertness. Therefore, it is necessary to recommend that patients should not drive or operate machinery until it is clearly determined by their own drug sensitivity.

Pregnancy

Reproductive toxicity is recorded in animal studies. Therefore, Quetiapin should only be used during pregnancy when the benefits are out of the risks that may occur.

The period of breastfeeding

Due to the lack of data sources, the decision to breastfeed or stop taking Sequequel XR, it is considered based on the benefits of breastfeeding and the treatment of the mother.

Drug interaction

Quetiapin mainly affects the central nervous system, so it is cautious when coordinating with drugs that affect other central nervous systems and deer.

Cytochrom P450 CYP3A4 is the main enzyme responsible for quetiapin metabolism. Contraindicated using quetiapin simultaneously with CYP3A4 inhibitors.

Simultaneous use of Quetiapin with strong liver -induced drugs such as carbamazepine or phenytoin can significantly reduce the quetiapin levels in plasma and thus reduce therapeutic effect.

Storage

Do not say at a temperature of more than 30 ° C. Store in original packaging.

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