SERTIL 100 KWACITY PHARMACEUTICAL TREATMENT TREATMENT, PANUDING SYSTEM (3 blisters x 10 tablets)
Dosage form Box of 3 blisters x 10 tablets
Specifications Sertraline
Ingredient
| Composition information | Content |
| Sertraline | 100mg |
Uses
indications
SERTIL 100 drugs are indicated in the following cases:
Sertralin is a substance of naphthylamine, which has antidepressant effects due to selective inhibition of recovery Serotonin (5 - hydroxytryptamine, 5 -HT). The drug is less or no inhibiting the recovery of noradrenalin or dopamine and has no antihistamine or α or β - adrenergic blockers at the dose of treatment. Therefore, common side effects due to Muscarin receptor blockers (such as dry mouth, blurred vision, urinary retention, constipation, confusion), receptor blockers α - adrenergic (causing hypituric posture loss) and receptor blockers H1 and H2 Histamine (for example, sleepiness) lower in sertralin users compared to anti -antidepressants three rpms and some other antidepressants and some other antidepressants. Sertralin does not inhibit monoaminoxidase.
pharmacokinetics
absorption:
Sertralin slowly absorbed through the digestive tract. The bioavailability of Sertralin is about 22-36% and the bioavailability of oral tablets is equivalent to the form of oral solution. If taking tablets along with food, AUC area increases slightly, the peak concentration increases by about 25% and the time to reach the peak concentration decreases from 8 hours to 5.5 hours.
If you take the solution with food, the time to reach the peak concentration in plasma increases from 5.9 hours to 7.0 hours. Time to reach the peak concentration of about 4.5 - 8.5 hours after drinking 50 - 200 mg once a day, for 14 days. The peak concentration and bioavailability of the increased drug in the elderly. The drug reaches a stable state after drinking about 1 week.
Distribution:
Sertralin is widely distributed into tissues and fluid fluids, through blood - brain and breast milk barriers. The drug is linked to plasma protein about 98%, mainly albumin and α1 - glycoprotein acid.
Metabolism:
Sertralin is metabolized in the liver, the main metabolite is N - Desmethylsertralin less active than Sertralin.
Era:
Sertralin is eliminated mainly in the form of transforming into feces and urine with an equal approximate amount. Half -life of Sertralin is about 25 - 26 hours and half -life of N - Desmethylsertralin is about 62 - 104 hours.
In the elderly, half a lifetime elimination can increase (about 36 hours). However, prolonged elimination is not clinically important and does not need to adjust the dose. Because the sertralin metabolizes strongly in the liver, the liver damage can affect the elimination of the drug. The manufacturer recommends carefully in the medication for people with liver damage, with lower doses or less doses. Sertralin's pharmacokinetics are not affected by kidney damage.
Before taking SERTIL 100 KWACITY PHARMACEUTICAL TREATMENT TREATMENT, PANUDING SYSTEM (3 blisters x 10 tablets)
How to use
Should take medicine once a day in the morning or afternoon. Food affects little drug absorption.
If you want to stop the drug, you have to reduce the dose slowly. Do not stop the drug suddenly to avoid cessation syndrome. No need to adjust the dose in people with renal failure. Use carefully and reduce the dose or reduce the number of times used in people with liver failure due to a large metabolic drug in the liver.
Dosage
depression:
Adults:
The starting dose of 50 mg, once a day. At least 1 week, if there is no clinical response, it can increase by step by 50 mg to a maximum dose of 200 mg per day.
Most patients respond to a dose of 50 - 100 mg daily. Each treatment lasts many months (usually about 6 months) to prevent the risk of recurrence.
There is no indication for people under 18 years old.
Rapid impulsive impulses:
Children 6 - 12 years old:
The starting dose is 25 mg, once a day.
Adults and children aged 13 and older:
The starting dose of 50mg, 1 time.
Every 1 week after the disease does not improve, then increase 50 mg daily (children 6 - 12 years old increase 25 mg) to a maximum dose of 200 mg per day. Most patients respond to a dose of 50 - 100mg per day (children 6 - 12 years old 25 - 50mg).
Not for children under 6 years old.
Panic disorder:
Adults:
The starting dose of 25 mg, once a day. Every 1 week, if the disease is not improved, it increases every day 25 mg to a maximum dose of 200 mg per day.
Stress disorder after injury:
Adults:
The starting dose of 25 mg, once a day. After a week, the dose must be increased to 50mg, once a day. If there is no significant clinical improvement, at least 1 week after a week can be increased by a maximum dose of 200 mg per day. Do not use for children.
Treatment time for 4 cases takes months or longer if the patient responds. But periodically, it is necessary to evaluate the results of treatment to reduce the lowest dose to be effective or before you want to stop the drug or transfer to other drugs.
anxiety disorder before menstruation:
Average dose of 50 - 150 mg/day.
Premature ejaculation disorders:
Average dose of 25 - 50 mg/day.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Common symptoms when overdose include: Drowsiness, anxiety, nausea, vomiting, tachycardia, map change, pupil dilatation. Some unwanted effects such as tachycardia, hypertension, high fever, red face, tremor of limbs have met in 1 child after drinking for sertralin, reacting like serotonin syndrome.
Handling: Sertralin has no specific antidote. So when overdose often treat symptoms and support treatment. If new poisoning, may cause vomiting. If the patient is in a coma or a seizure without vomiting, then the stomach wash after the intubation of the trachea to avoid breathing in the stomach. Using activated carbon (can be coordinated with sorbitol) from the beginning or after causing vomiting and gastric lavage. It is necessary to maintain the respiration of the patient, ventilation and oxygen breathing. Methods of hemolysis, abdominal division, forced diuretic, blood transfusion are ineffective due to the large distribution of Sertralin and highly linked to protein.
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Servil 100, you may experience unwanted effects (ADR).
Common, ADR> 1/100
On gastrointestinal: nausea, dry mouth, diarrhea, constipation, indigestion, anorexia, flatulence, abdominal pain, taste disorders.
On skeletal muscle: muscle pain, back pain.
Uncommon, 1/1000 Cardiovascular, blood pressure: tachycardia, vasodilation, hypotension, hypotension, peripheral vascular spasms, hypertension. Rare, ADR Skin reactions: bullous, eczema, contact dermatitis, skin discoloration and him. Allergic reactions: edema and some dangerous skin reactions that can be fatal like Stevens - Johnson, vasculitis, many types of erythematosus. On blood: abnormal bleeding or bleeding due to porphyrin lower. Change platelet function. In addition, thrombosis, anemia. Instructions on how to handle ADR: The drug is only used as prescribed by the doctor. Notify the doctor if any side effects occur during the drug. If you need more information, please consult a doctor.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
contraindicated
SERTIL 100 contraindications in the following cases:
are using or used imao for two weeks can lead to death.
Be cautious when using
due to people with depression or suicidal ideas or behavior, especially when using medication, so it is necessary to closely monitor the patient and start low doses to reduce the risk of overdose. In the treatment of haunting forced impulses, especially in children need to be closely supervised.
Use carefully with alcoholics.
Although Sertralin is less likely to cause drowsiness than other antidepressants, it still has to be cautious with the train driver or operating machinery and especially when used simultaneously with central neurological inhibitors.
Use cautiously with patients with epilepsy, manic, blood disorders, liver failure, kidney failure, sodium hypoglycemia, anorexia, weight loss, thyroid failure. The dose should be reduced in patients with liver failure.
Be careful to use Sertralin for the elderly because it is prone to sodium hypoglycemia and unsuitable anti -urinary hormone syndrome (SIADH). Need to monitor sodium blood periodically (especially in the first few months).
Sertralin can cause anorexia and weight loss, so it is necessary to be cautious when used for mild weight patients.
It is necessary to consider the risk of Serotonin syndrome when using the Serotonin Selective Inhibitors (SSRI).
The ability to drive and operate machinery
should not be used while driving and operating machinery.
Pregnancy
There is no research document on using sertralin for pregnant women. However, due to the drug through the placenta, it can cause unwanted effects on the fetus's nerves. Therefore, do not use sertralin during pregnancy unless it is necessary, when considering the benefits greater than the risk.
The period of breastfeeding
Sertralin is distributed into breast milk, so it can cause unwanted effects for breastfed babies. Therefore, women who are breastfeeding using sertralin must be very cautious.
Medicinal interaction
Some drugs that use the same serotonin syndrome: Serotonin syndrome: antidepressants inhibit the recovery of serotonin and other antidepressants, serotonergic systems (Serotonin secretion).
In particular, not combined with sertralin with Mao inhibitors or within two weeks after stopping treatment with Mao inhibitors because it can cause serotonin syndrome, life -threatening.
Sumatriptan: Sertralin when used simultaneously with Sumatriptan may increase the frequency of migraine, fatigue, reflex reduction and loss of coordination.
Metabolic drugs through the liver or affect the liver microsom enzyme: Sertralin is metabolized by Cytochom P450 enzyme (CYP) 2D6, while inhibiting the activity of the enzyme. Therefore, it is necessary to be cautious when using Sertralin simultaneously with the metabolites by CYP 2D6, especially those with narrow treatment index such as three -ring antidepressants, anti -arrhythmia IC (Propafenon, Flecainid) and some phenothiazine such as Thioridazin because it can cause unwanted effects and toxicity of the drug.
The drug is associated with protein: Because sertralin is attached to plasma proteins, it is necessary to be cautious when used with the same drugs that are also attached to plasma proteins (anticoagulant drugs, digitoxin ...) because it can increase toxicity. For digoxin, do not need to adjust the dose.
Other drugs: Be careful when taking sertralin and drugs such as benzodiazepin, lithium, alcohol, blood glucose, cimetidine because it can increase unwanted effects.
Do not coordinate sertralin in patients using Linezolid because it can cause serotonin syndrome.
Storage
Store in a dry, cool place at temperatures below 30 ° C, avoiding light.
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