SERTIL 50 KWACITY PHARMACEUTICAL TREATMENT TREATMENT, PANUTION SOLUTION (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Sertraline

Ingredient

Composition information	Content
Sertraline	50mg

Uses

indications

SERTIL 50 drugs are indicated in the following cases:

Depression.

Panic syndrome. naphthylamine, has antidepressant effect due to selective inhibition of recovery Serotonin (5-hydroxytryptamin 5-HT). The drug is small or has no re-inhibiting the recovery of Noradrenalin or dopamine and has no antihistamine or α or β-adrenergic blockers at the dose of treatment. Therefore, the common side effects due to the bloating of Muscarin receptors (such as dry mouth, blurred vision, urination, constipation, confusion), α-adrenergic receptor blockers (causing vertical posture reduction) and H1 and H2 receptor blockers of histamine (for example, drowsiness) is less than those who use sertralin compared to those who antidepressant drugs and some other antidepressants. Sertralin does not inhibit monoaminoxidase.

Dynamic pharmacokinetics

absorption: Sertraline absorbs slowly through the gastrointestinal tract. The bioavailability of Sertralin is about 22-36% and the bioavailability of oral tablets is equivalent to the form of oral solution. If taking tablets along with food, AUC area increases slightly, the peak concentration increases by about 25% and the time to reach the peak concentration decreases from 8 hours to 5.5 hours.

Distribution: Sertralin is widely distributed into tissues and fluid fluids, through the fence and breast milk. The drug is linked to plasma proteins about 98%, mainly albumin and α-acid glycoprotein.

Metabolism: Sertralin is metabolized in the liver, the main metabolic substance is N-Desmethylsertralin less active than sertralin.

Erimization: Sertralin is excreted mainly in the form of metabolism of feces and urine with an equal approximate amount. Sertralin waste time is about 25-26 hours and of N-Desmethylsertralin about 62-104 hours.

Before taking SERTIL 50 KWACITY PHARMACEUTICAL TREATMENT TREATMENT, PANUTION SOLUTION (3 blisters x 10 tablets)

How to use

Should take medicine once a day in the morning or afternoon. Food affects little drug absorption.

Dosage

Depression:

Adults, starting at 50 mg, once a day. At least 1 week, if there is no clinical response, it can increase by step by 50 mg to a maximum dose of 200 mg per day. Most patients respond to a dose of 50 - 100 mg per day. Each treatment lasts many months (usually about 6 months) to prevent the risk of recurrence. There is no indication for people under 18 years old.

Rapid impulsive impulses:

Adults and children aged 13 and older, starting at 50 mg.

Children 6 - 12 years 25 mg, once a day. At least 1 week after the disease, if the disease does not improve, it will increase every day by 50 mg (children 6 - 12 years old increase 25 mg) to a maximum dose of 200 mg per day. Most patients respond to a dose of 50 - 100 mg per day (children 6 - 12 years old 25 - 50mg). Do not use for children under 6 years old.

Panic disorder:

Adults start 25 mg, once a day. Every 1 week, if the disease is not improved, it increases every day 25mg to a maximum dose of 200 mg per day.

Stress disorder after injury:

Adults, the starting dose of 25 mg, once a day. After a week, the dose must be increased to 50 mg, once a day. If there is no significant clinical improvement, at least 1 week after a week can be increased by a maximum dose of 200 mg per day. Do not use for children.

Treatment time for 4 cases takes months or longer if the patient responds. But periodically, it is necessary to evaluate the results of treatment to reduce the lowest dose to be effective or before you want to stop the drug or transfer to other drugs.

Anxiety disorders before menstruation: Average dose of 50 - 150 mg/day.

Premature ejaculation disorders: Average dose of 25 - 50 mg/day.

If you want to stop the drug, you have to reduce the dose slowly. Do not stop the drug suddenly to avoid cessation syndrome. No need to adjust the dose in people with renal failure. Use carefully and reduce the dose or reduce the number of times used in people with liver failure due to a large metabolic drug in the liver.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Common symptoms when overdose include: Drowsiness, anxiety, nausea, vomiting, tachycardia, map change, pupil dilatation. Some unwanted effects such as tachycardia, hypertension, high fever, red face, tremor of the heads have met in a child after taking the wrong sertralin, the reaction is like serotonin syndrome.

Sertralin has no specific antidote. So when overdose often treat symptoms and support treatment. If new poisoning, may cause vomiting. If the patient is in a coma or a seizure without vomiting, then the stomach wash after the intubation of the trachea to avoid breathing in the stomach. Using activated carbon (can be coordinated with sorbitol) from the beginning or after causing vomiting and gastric lavage. It is necessary to maintain the respiration of the patient, ventilation and oxygen breathing. Methods of hemolysis, abdominal division, forced diuretic, blood transfusion are ineffective due to the large distribution of Sertralin and highly linked to protein.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using SERTIL 50, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Systemic body: uncomfortable, chest pain, weakness, hot fever, weight gain.

Eye: visual disorders.

Heart: Brushing the chest.

Body: Peripheral edema, chills, thirst.

Digestive: Disorders of tooth, esophagitis, inflammation, salivation, difficulty swallowing, reflux.

Instructions on how to handle ADR

Most of the above side effects are light and often disappear when patients continue to take the drug. Ask your doctor if you still have those symptoms.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated:

Hypersensitivity to the drug.

Be cautious when using

due to people with depression or suicidal ideas or behaviors, especially when using the drug, so it is necessary to closely monitor patients and start low doses to reduce the risk of overdose. In the treatment of haunting forced impulses, especially in children need to be closely supervised.

Use carefully with alcoholics.

Although Sertralin is less likely to cause drowsiness than other antidepressants, it still has to be cautious with the train driver or operating machinery and especially when used simultaneously with neurological inhibitors.

Use carefully with patients with epilepsy, manic, blood disorders, liver failure, kidney failure, anorexia, weight loss, thyroid failure. The dose should be reduced in patients with liver failure.

Be careful to use Sertralin for the elderly because it is prone to sodium hypoglycemia and unsuitable anti -urinary hormone syndrome (SIADH). Periodic monitoring (especially in the first few months) sodium blood.

Sertralin can cause anorexia and weight loss, so it is necessary to be cautious when used for mild weight patients.

The ability to drive and operate machinery

should not be used while driving and operating machinery.

Pregnancy

There is no research document on using sertralin for pregnant women. However, due to the drug through the placenta, it can cause unwanted effects on the fetus's nerves. Therefore, do not use sertralin during pregnancy unless it is necessary, when considering the benefits greater than the risk.

The period of breastfeeding

Sertralin allocated into breast milk, so it can cause unwanted effects for breastfed babies. Therefore, women who are breastfeeding using sertralin must be very cautious.

Medicinal interaction

Some drugs that use the same serotonin syndrome: Serotonin syndrome: antidepressants inhibit the recovery of serotonin and other antidepressants, serotonergic systems (Serotonin secretion).

In particular, not combined with sertralin with Mao inhibitors or within two weeks after stopping treatment with Mao inhibitors because it can cause serotonin syndrome, life -threatening.

Sumatriptan: Sertralin when used simultaneously with Sumatriptan may increase the frequency of migraine, fatigue, reflex reduction and loss of coordination.

Metabolic drugs through the liver or affect the liver microsom enzyme: Sertralin is metabolized by the cytochom P450 CYP2D6 enzyme, while inhibiting the activity of the enzyme. Therefore, it is necessary to be cautious when using Sertralin simultaneously with the metabolites by CYP2D6, especially those with narrow treatment index such as three -round antidepressants, anti -arrhythmia IC (Propafenone, Flecainide) and some phenothiazin such as Thioridazin because it can cause unwanted effects and toxicity of the drug.

Because sertralin is highly attached to plasma proteins, careful use of the same drugs also attached to plasma proteins such as anticoagulant, digitoxin ... because it can increase toxicity. For digoxin, do not need to adjust the dose.

Other drugs: Be careful when taking sertralin and drugs such as benzodiazepin, lithium, alcohol, blood glucose, cimetidine because it can increase unwanted effects.

Storage

Store in closed boxes at room temperature. Avoid light.

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