Sezstad 10 Stella medicine for hypercholesterolemia (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Ezetimibe

Ingredient

Composition information	Content
Ezetimibe	10mg

Uses

Indications

Primary cholesterol hypertrophy:

Single therapy: Support treatment with diets in patients with primary blood cholesterol (heterozygous and non -family) inappropriate or intolerant to the statin group. communal house) is not well controlled with the prescription of Statin.

Use in combination with Statin medication: Support treatment with diet in patients with homozygous blood cholesterol.

Hypertostatic hypertension (blood phytosterol):

Support treatment with diet in patients with hyperplasia Sitosterols.

Pharmacokinus

Ezetimibe is a cholesterol absorption inhibitor that lowers blood lipids, has a chemical structure and pharmacological effects with other IIPID lowering drugs. After absorption, the positioning drug in the small intestine and prevent the absorption of cholesterol, reducing the transport of cholesterol from the intestine into the liver, leading to a decrease in the amount of cholesterol reserves in the liver and the liver will increase cholesterol reception from the circulatory system according to the compensation mechanism, resulting in increased cholesterol waste from the circulatory system.

pharmacokinetics

absorption:

Ezetimibe quickly absorbed after drinking.

Distribution:

Both Ezetimibe and Glucuronid are attached to plasma proteins over 90%.

Metabolism:

In the small intestine and liver, Ezetimibe converts into active glucuronid metabolites.

Era:

Ezetimibe excreted mainly in biliary fertilizer and undergoing the liver cycle. After drinking, about 78% is excreted in feces in the form of ezetimibe, about 11% excreted in urine mainly in the form of glucuronid. Ezetimibe and glucuronid waste time is about 22 hours.

Before taking Sezstad 10 Stella medicine for hypercholesterolemia (3 blisters x 10 tablets)

How to use

Sezstad 10 is used by oral, at any time of the day, together or not with food. Patients should have a suitable diet, low in fat and continue this diet during treatment.

Coordinate with other lipid remedies:

Ezetimibe can be taken with statin medication (for patients with primary lipid hyperlemen) or fenofibrat (for patients with hyperlipidemia combined) to achieve higher treatment effect. Daily dose can be taken at the same time as Statin or Fenofibrat groups at the recommended dose of each drug.

Collaborate with bile acid absorption drugs:

Should take Ezetimibe at least 2 hours before 2 hours or 4 hours when taking bile acid absorption.

Dosage

Recommended dose: 1 tablet/day.

Children and minors from 10 years of age: No need to dose.

Children under 10 years of age: It is not recommended to use Ezetimibe because there is no sufficient information about the safety and effectiveness of the drug in this object.

Patients with liver failure or renal failure: No dose adjustment for patients with hepatic or mild kidney failure.

Elderly: No dose needed.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose?

In case of overdose, symptomatic treatment and supportive treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Common, ADR> 1/100

Neurology: headache ;

digestive: abdominal pain, diarrhea ;

DA: rash;

Evaluation: Feng shallow;

Body: fatigue, chest pain;

musculoskeletal: joint pain.

Uncommon, 1/1000

No report.

Rare, ADR

Liver: Increased liver enzyme or hepatitis, gallstones , cholecystitis;

Digestive system: pancreatitis ;

Blood and lymphatic system: thrombocytopenia.

Instructions on how to handle ADR:

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

contraindicated

sensitive to Ezetimibe or any ingredients of the drug.

Ezetimibe combination treatment with statin group for pregnant women and nursing women.

Ezetimibe combination treatment with statin medication in patients with progressive liver disease or increased serum transaminase for unknown cause.

Caution when using

enzyme liver

Continuous transaminase increase (≥ 3 times the upper limit of normal levels (ULN)) has been noted in patients using Ezetimibe simultaneously with statin medication. When combining Ezetimibe with Statin medication, liver function is needed when it is started to treat and follow the recommendations of the statin group.

Muscle system

There have been reports of muscle disease and muscle diseases in some patients using Ezetimibe. Stop immediately Ezetimibe, Statin medication, or any combination of drugs when patients suspect muscle -based muscle diseases or muscle symptoms or creatinine phosphokinase levels higher than 10 times higher than the upper limit of normal levels (ULN).

excipients

Sezstad 10 contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or inertia giucose-galactose.

The ability to drive and operate machinery

There has been no research on the effect of the drug on the ability to drive and operate machinery. However, because the drug has the potential to cause dizziness, it is possible to consider using the drug when driving or operating machinery.

Pregnancy

Ezetimibe should only be used for pregnant women when really necessary. There is no clinical report on the use of ezetimibe in pregnant women. Animal studies show that the use of Ezetimibe therapy has no direct or indirect harmful effects on pregnant women, the development of the fetus, infants or the development of the baby after birth.

The period of breastfeeding

ezetimibe should not be used for nursing women. Mouse studies show that Ezetimibe is excreted in mother mouse milk. In humans, it is not known whether ezetimibe will excrete in breast milk or not.

Drug interaction

cholestyramin : Treatment combined with cholestyramin reduces the area under the curve of total ezetimibe (ezetimibe + ezetimibe glucuronid) about 55%. Reducing the increase in low density lipoprotein cholesterol (LDL - C) may be weakened by interactions between Ezetimibe and Cholestyramin.

Fibrat group: In patients treated with fenofibrat and ezetimibe at the same time, the doctor should pay attention to the risk of gallstones and gallbladder disease. If you suspect gallstones in patients using Ezetimibe and Fenofibrat, gallbladder examination and treatment stop.

Cyclosporin: Cyclosporin increases the plasma concentration of ezetimibe, patients use two medications simultaneously need to be carefully monitored. This effect can increase in patients with severe renal failure.

Anticoneal drugs: In a study of 12 healthy adult men, using Ezetimibe combination (10 mg once a day) with anticoagulants does not significantly affect the bioavailability of warfarin and prothrombin time. However, there has been a report on increasing international normalization index (INR) when used in combination with Ezetimibe with Warfarin or Fluindion. It is necessary to monitor the INR index if combined with ezetimibe with warfarin, other anticoagulants or fluindion.

Storage

Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

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