Sezstad 10 Stella medicine for hypercholesterolemia (6 blisters x 10 tablets)

Dosage form Box of 6 blisters x 10 tablets
Specifications Ezetimibe

Ingredient

Composition information	Content
Ezetimibe	10mg

Uses

indications

Sezstad 10 drugs are indicated in the following cases:

Increasing primary blood cholesterol

Single therapy: Support treatment with diets in patients with primary blood cholesterol (heterozygous and non -family) inappropriate or intolerant to the statin group.

Treatment in combination with HMG - COA (Statin group): Support treatment with diet in patients with primary blood cholesterol (heterozygous and unmarried) is not well controlled with the statin group.

Hypersensitivity to homozygous blood (HOFH)

Use in combination with giabol medicine. Supporting treatment with Indian abstinence in patients with homozygous blood cholesterol.

Homosexual hyperlesto blood cholesterol

Support treatment with diet in patients with hypergonary blood sitosterols.

Pharmacokology

Pharmacological group: Other lipid adjustments.

ATC code: C10AX09.

Ezetimibe, cholesterol absorption inhibitor, is a hypoglycemia, chemical structure and pharmacological effects different from other lipid medications. After absorbing, the drug is located at the small intestine and prevents the absorption of cholesterol, reducing the transport of cholesterol from the intestine into the liver. As a decrease in the amount of cholesterol reserves in the liver, the liver will increase cholesterol from the circulatory system according to the clearing mechanism, resulting in increased cholesterol clearance from the circulatory system.

Dynamic pharmacokinetics

Ezetimibe quickly absorbed after drinking and undergo a conjugated reaction in the small intestine and the liver into an active glucuronid metabolitus. Both Ezetimibe and Glucuronid are attached to plasma proteins over 90%. Ezetimibe excreted mainly in biliary fertilizer and undergoing the liver cycle.

After drinking, about 78% is excreted in feces in the form of ezetimibe, about 11% excreted in urine mainly in the form of glucuronid.

Before taking Sezstad 10 Stella medicine for hypercholesterolemia (6 blisters x 10 tablets)

How to use

Sezstad 10 is used by oral, anytime of the day, together or not with food.

Patients should have a suitable diet, low in fat and continue this diet.

coordinated with other lipid medications

Ezetimibe can be taken with statin medication (for patients with primary hyperglycemia) or fenofibrat (for patients with hyperlipidemia combined) to achieve higher treatment effect.

Willow daily can be taken at the same time as Statin or Fenofibrat groups at the recommended dose of each drug.

combined with bile acid absorption drug

Should take Ezetimibe at least 2 hours before 2 hours or 4 hours when taking bile acid absorption.

Dosage

Dosage: One tablet daily.

Children and minors from 10 years of age: No need to dose.

Children under 10 years of age: It is not recommended to use Ezetimibe because there is no sufficient information about the safety and effectiveness of the drug for children under 10 years old.

Patients with liver failure or renal failure: No dose adjustment for patients with hepatic or mild kidney failure.

Elderly: Do not bite the dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Sezstad 10 you may experience unwanted effects (ADR):

Common (1/100

Rare (1/10,000 Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Sezstad 10 contraindications in the following cases:

Hypersensitivity to Ezetimibe or any ingredients of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

liver enzyme

Continuous transaminase increase (2 3 times the upper limit of normal levels (ULN) has been noticed in patients using Ezetimibe simultaneously with statin medication. When combining Ezetimibe with Statin medication, liver function is needed when it is started to treat and follow the recommendations of the statin group.

Muscle system

There have been reports of muscle disease and muscle explanation in some patients using Ezetimibe. Stop immediately Ezetimibe, Statin medication, or any combination of drugs when patients suspect muscle -based muscle diseases or muscle symptoms or creatinine phosphokinase levels higher than 10 times higher than the upper limit of normal levels (ULN).

excipients

Sezstad 10 contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or poorly absorbed glucose-galactose.

The effect of the drug on driving and operating machinery

There has been no research on the effect of the drug on the ability to drive and operate machinery. However, because the drug is likely to cause dizziness, it is possible to consider using the drug when driving or operating machinery.

Use drugs for women during pregnancy and lactation

Pregnant women

Ezetimibe should only be used for pregnant women when necessary. There is no clinical report on the use of ezetimibe in pregnant women. Animal studies show that the use of Ezetimibe therapy has no direct or indirect harmful effects on pregnant women, the development of the fetus, infants or the development of the baby after birth.

breastfeeding women

Ezetimibe should not be used for breastfeeding women. Mouse studies show that Ezetimibe is excreted in mother mouse milk. In humans, it is not known whether ezetimibe will excrete in breast milk or not.

Drug interaction

cholestyramin: Treatment combined with cholestyramin reduces the area under the curve of the total ezetimibe (ezetimibe + ezetimibe glucuronid) about 55%. Reducing the increase in low density lipoprotein cholesterol (LDL-C) may be weakened by interactions between Ezetimibe and Cholestyramin.

Fibrat group: In patients treated with fenofibrat and ezetimibe at the same time, the doctor should pay attention to the risk of gallstones and gallbladder disease. If you suspect gallstones in patients using Ezetimibe and Fenofibrat, gallbladder examination and treatment stop.

Statin group: There has not been a serious clinical interaction that occurs when using Ezetimibe with Atorvastatin, Simvastatin, Pravastatin, Lovastatin, Fluvastatin or RosuVastatin.

ciclosporin: Ciclosporin increases the plasma concentration of ezetimibe, patients use two simultaneously two drugs that need to be carefully monitored. This effect can increase in patients with severe renal failure.

Anticoneal drugs: In a study of 12 healthy adult men, using Ezetimibe combination (10 mg once a day) with anticoagulant drugs that do not significantly affect the bioavailability of warfarin and prothrombin time. However, there has been a report on increasing international normalization index (INR) when used in combination with Ezetimibe with Warfarin or Fluindion. Inr index should be followed if combined with ezetimibe with warfarin, other anticoagulants, or fluindion.

Cavalry: Due to no studies on the correlation of the drug, do not mix this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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