Shinacin shinpoong deawoo treatment for respiratory and urinary tract infections (5 blisters x 6 tablets)

Dosage form Box of 5 blisters x 6 tablets
Specifications Amoxicillin, clavulanic acid

Ingredient

Composition information	Content
Amoxicillin	500mg
Clavulanic Acid	125mg

Uses

indications

Shinacin drugs are indicated in the following cases:

Treatment of infections caused by sensitive bacteria. Management. Dental bacteria: tooth abscess. But because Amoxicillin is easily destroyed by betalactamase, it has no effect on bacterial strains producing these enzymes.

Clavulanic acid formed by the fermentation of Streptomyces Clavuligerus, which has a beta-lactam structure similar to penicillin, capable of inhibiting beta-lactamase due to the majority of Gram (-) and Staphylococcus bacteria. Especially, it has a strong inhibition effect of beta-lactamase transmitted via plasmid that resists penicillines and cephalosporins.

Clavulanic acid helps Amoxicillin not be destroyed by beta-lactamase, and expand the antibacterial spectrum of amoxicillin effectively to many common bacteria that have resisted amoxicillin, other penicillins and cephalosporins.

The antibacterial spectrum of the drug includes:

Gram (+) bacteria

Aerobic type: Streptococcus Faecalis, Streptococcus Pneumoniae, Streptococcus Pyogenes, Streptococcus Viridans, Staphylococcus aureus, Corynebacterium Bacillus anthracis, Listeria monocytogenes. Clostridium, peptococcus, peptostreptococcus.

Gram (-) bacteria

Aerobic type: Haemophilus Influenzae, Escherichia Coli, Proteus Mirabilis, Proteus vulgaris, Klebsiella, Salmonella, Shigella, Bordetella, Neisserrria Meningitidis, Neisseria Gonorrhoeea, Vibrio Cholerae, Pasteee Multocida.

anaerobic type: Bacteroides, including bacteroides fragilis. The concentration of these 2 substances in the serum is maximum after 1-2 hours of taking the drug. With a dose of 250 mg (or 500 mg) will have 5 micrograms/ml (or 8 - 9 micrograms) amoxicillin and about 3 micrograms/ml of clavulanate acid in serum.

After 1 hour oral 20 mg/kg amoxicillin + 5 mg/kg Clavulanic acid, there will be an average of 8.7 micrograms/ml of amoxicillin and 3.0 micrograms/ml of clavulanic acid in serum. The absorption of the drug is not affected by food and it is best to drink right before the meal.

The oral bioactivity of amoxicillin is 90% and of Clavulanic acid is 75%. The half -life of amoxicillin in serum is 1-2 hours and of Clavulanic acid is about 1 hour. About 55 - 70% amoxicillin and 30-40% Clavulanic acid are discharged in urine in the form of activity. Probenecid extends the excretion time of amoxicillin but does not affect the elimination of clavulanic acid.

Before taking Shinacin shinpoong deawoo treatment for respiratory and urinary tract infections (5 blisters x 6 tablets)

How to use

Dissolve shinacin into water at least 1 teaspoon of water and give children immediately.

Take medicine at the beginning of eating to minimize the phenomenon of intolerance in the stomach - intestines.

Do not take shinacin for more than 14 days without checking the treatment.

Dosage

Children over 40 kg

20 - 40 mg amoxicillin kg/day, divided into several times 8 hours apart.

Children under 40 kg

Normal dose: 20 mg amoxicillin kg/day, divided into several times 8 hours apart.

To treat otitis media, sinusitis, lower respiratory tract infections and severe bacterial infections, usual doses: 40 mg amoxicillin/kg/day, divided into 8 hours apart, for 5 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? In case the kidney function decreases and the blood -brain barrier, the injection will cause symptoms of poisoning. However, in general, the acute reactions occur depending on the hypersensitivity of each body. The risk is definitely hyperkalemia when taking a very high dose because clavulanic acid is used in the form of potassium salt. Can use the method of hemolysis so that the drug is from circulation.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using shinacin, you may experience unwanted effects (ADR).

With normal doses, unwanted effects show over 5% of patients; The most common are the reactions on diarrhea, nausea, vomiting.

This reaction rate increases when used higher and more common than using amoxicillin.

Common, ADR> 1/100

Digestive: diarrhea.

Skin: Outdoor, itching.

Uncommon, 1/1000

Blood: Nothing hypernagus.

Digestive: Nausea, vomiting.

Liver: Hepatitis and jaundice, increased transaminase, can be severe and last for several months

Skin: itching, erythema, rash.

Rare, ADR

Systemic: Anaphylaxis reaction, Phu Quincke.

Blood: A mitigation of platelet, leukopenia, hemolytic anemia.

digestive: fake colitis.

Skin: Stevens - Johnson syndrome, diverse erythema, peeling dermatitis, epidermal necrosis due to poisoning.

kidney: interstitial nephritis.

Instructions on how to handle ADR

When experiencing side effects of shinacin, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

SHINACIN drug contraindicated in the following cases:

Hypersensitivity to the ingredients of the drug.

allergies to the beta - lactam group.

Cross allergy to beta - lactam antibiotics as cephalosporins.

Patients with a history of jaundice disorders of liver dysfunction due to the use of amoxicillin and clavulanate or penicillin because clavulanic acid causes increased risk in the liver.

Caution when used

Patients with signs of liver dysfunction: Signs and symptoms of cholestasis jaundice occur rarely when taking the drug but may be severe. However, those symptoms are often recovered and will end after 6 weeks of stopping treatment.

Patients with average or severe renal failure should pay attention to the dose.

Patients with a history of hypersensitivity to penicillin may have severe or death reactions.

Patients with amoxicillin use redness with lymphadenous fever.

Taking drugs for prolonged drugs sometimes develops resistant bacteria.

Patients with phenyl kinema.

The ability to drive and operate machinery

Shinacin does not affect the ability to drive and operate machinery.

Pregnancy

Experimental research on the reproductive process of mice proved when using oral preparations and injections that do not cause deformities. However, because there is little experience in using preparations for pregnant women, it is necessary to avoid using drugs in pregnant women, especially in the first 3 months, except for the necessary cases prescribed by a physician.

The period of breastfeeding

during breastfeeding may be used. The drug is not harmful to breastfed children unless there is a risk of sensitivity due to a very small amount of drugs in milk.

Drug interaction

Shinacin can cause prolonged bleeding time and blood clotting, so be careful for patients who are being treated with anticoagulants.

Like antibiotics with broad effects, the drug can reduce the effectiveness of oral contraceptives, so it is necessary to notice to the patient in advance.

Storage

Storage in closed packaging, in dry places, avoid light, temperatures below 30 ° C.

Other drugs

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