Siberizin 5mg Starch drugs for preventing migraine prevention (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Flunarizine

Ingredient

Composition information	Content
Flunarizine	5mg

Uses

indications

Siberizin is indicated for preventing the prevention of migraine in case other treatments are not effective or ineffective.

Pharmacological

Siberizin contains the active ingredient Flunarizin is Cinnarizin's Diflouriant derivatives. The drug has antihistamine, sedative and calcium channel blockers. Flunarizin is used to prevent migraine, dizziness due to vestibular disorders and cerebrovascular disorders. The drug is also used in combination with anti -epileptic drugs to treat epilepsy for patients who do not respond to standard treatment regimens.

The mechanism of action of flunarizin has not been completely clarified. It may be due to the calcium inhibitor that reduces calcium overload in cells, thus having the effect of relaxing brain blood vessels. In addition, it may also be due to inhibiting vascular contraction due to reducing intermediate substances such as serotonin, prostaglandin, increasing oxygen supply to nerve cells, improving blood viscosity. Unlike Ergostamin, Flunarizin does not affect the contractions and myocardial transmission.

Dynamic pharmacokinetics

After taken, the drug is well absorbed through the digestive tract, reaching the peak concentration in plasma within 2 to 4 hours and reaching the status of constant at the 4th week to the 5th week. After complete metabolism through the liver, the drug and the metabolites are excreted in biliary tract. The end of the drug is about 18 days.

Before taking Siberizin 5mg Starch drugs for preventing migraine prevention (10 blisters x 10 tablets)

How to use

Take oral use.

Dosage

Adults ≤ 65 years old and elderly (> 65 years)

5 mg/day, taken in the evening, maintained for 4 to 8 weeks.

During treatment, if the symptoms of depression, foreign tower or other serious adverse events appear, it is necessary to stop taking the drug.

If after 8 weeks of treatment there is no improvement, the patient is considered not responded to treatment and should stop taking the drug.

Treatment time does not exceed 6 months.

Recommended for patients ≤ 65 years old: If the patient's clinical manifestation shows that the response is incomplete, may increase the dose up to 10 mg/day but need to consider in the patient's tolerance capacity.

Children

Children ≥ 12 years old, especially in the case of unexplained migraine: 5 mg/day, taken in the evening. Treatment period must not exceed 6 months.

Children

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? There is no specific antidote. Gastrointestinal lavage or active carbon if necessary.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using siberizin, you may experience unwanted effects (ADR).

In general, siberizin tolerates well. Side effects occur when starting to use the drug is usually mild, including drowsiness, fatigue, weight gain or appetite. The drug can cause depression or extracurricular symptoms (tremor, movement disorders) on elderly patients who have to treat long -term treatment.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Siberizin drugs contraindicated in the following cases:

Hypersensitivity to flunarizin or any excipients of the drug.

Symptoms of Parkinson's disease before treatment.

History of foreign symptoms.

depression or history with recurrent depression syndrome.

Be cautious when using

Patients with liver disease or porphyrin metabolism disorders

Do not use siberizin exceeding the recommended dose. It is necessary to monitor patients regularly, periodically, especially during the maintenance treatment period to early detect expressions of foreign tapes, depression and stop treatment promptly.

Some fatigue cases with increasing severity have been recorded when using flunarizin. If this condition occurs, it is necessary to stop treating with flunarizin.

The ability to drive and operate machinery

Siberizin can cause sleepiness for patients in the early stages of treatment. Therefore, it is necessary to be cautious when driving or operating machinery.

pregnancy

Animal studies show that the drug is not directly or indirectly harmful to reproduction, the development of embryos and pregnancy process. However, due to the safety of the drug in pregnant women has not been fully evaluated, do not use siberizin for pregnant women.

The period of breastfeeding

Animal research has shown that flunarizin is excreted in breast milk with higher concentrations in plasma. There is no data about the excretion of milk in humans. Therefore, it is not recommended to use siberizin for nursing women.

Interactive drug

used in combination with liver enzyme stimulants (carbamazepin, phenytoin) may increase the metabolism of siberizin. Therefore, it is necessary to increase the dose of siberizin.

Alcohol and sedative can increase Siberizin's sleepy side.

Storage

Store in a cool dry place, avoid direct light, temperature below 30 ° C.

Other drugs

Disclaimer

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