Siro Bisolvon Kids Boehringer dilutes phlegm in acute and chronic bronchial diseases (60ml)

Dosage form Syrup
Specifications Bottle x 60ml
Ingredient Bromhexin hydrochlorid
Indication Acute bronchitis, chronic bronchitis
Contraindication Drug allergy

Ingredient

Thành phần cho 5ml

Composition informationContent
Bromhexin hydrochlorid4mg

Uses

Indications

Bisolvon drugs are indicated to dilute phlegm in acute and chronic bronchial diseases accompanied by abnormal mucus secretion and weakened mucus transport.

Pharmacokinus

bromhexin is a synthetic derivative from the active ingredient Vasicine.

Clinically, bromhexin is notice that increases the ratio of bronchodilatoma. Bromhexin increases the transport of mucus by reducing the mucus and active activity with mucus (expuled with mucus).

In clinical trials, bromhexin shows the effect of diluting the secretion and transporting secretions in the bronchial sugar to facilitate the sputum and cough.

After treating with bromhexin, antibiotic concentration (amoxicillin, erythromycin, oxytetracydin) in phlegm and bronchial secretions increase.

pharmacokinetic

absorption

Bromhexin is absorbed quickly and completely through the gastrointestinal tract.

Birth is equivalent after taking solid form and solution.

Absolute bioavailability of Hydrochloride Bromhexin is about 22.2 ± 8.5 % and 26.8 ± 13.1 % corresponding to Bisolvon tablets and solutions.

The first amount of metabolites is about 75 - 80 %.

Use the same food leading to increased plasma bromhexine levels.

Distribution

After using intravenous lines, bromhexin is distributed quickly and widely throughout the body with average distribution (VSS) up to 1209 ± 206 l (19 l/kg). Has studied the distribution into the lung tissue (bronchial and parenchyma) after taking 32 mg and 64 mg of bromhexin. The concentration of lung tissue after 2 hours of drug use, concentration at bronchial - bronchial tissue is 1.5 - 4.5 times higher and in pulmonary parenchyma is about 2.4 - 5.9 than plasma concentrations.

Bromhexin binding in a constant form with plasma proteins is about 95% (unlimited link).

Metabolism

Bromhexin metabolizes almost completely into diverse hydroxy metabolites and into dibromanthanilic acid. All metabolites and bromhexin themselves are combined in the form of n-glucuronide and o-glucuronide. There is no significant evidence of changing the metabolic method caused by sulphonamid, oxytetracycline or erhthromycin. Therefore, the corresponding interaction is due to CYP 450 2C9 and 3 A4.

Elimination

After using intravenous tract, bromhexin has a high rate of extraction within the range of blood flow through the liver, 843 -1073 ml/minute leads to a large difference between individuals and on the same individual (CV> 30%). After using bromhexin with radioactive marking, about 97.4 % ± 1.9 % of the dose found in the form of radioactive in the urine, with the original active ingredient below 1 %. Plasma bromhexin concentration decreases with exponential expansion. After taking single -dose from 8 to 32 mg, the last half -life is in the range of 6.6 - 31.4 hours. Half -life relevant lifetime to attend multi -dose pharmacokinetics is about 1 hour, so there is no accumulation after multi -dose use (accumulation coefficient 1.1).

Before taking Siro Bisolvon Kids Boehringer dilutes phlegm in acute and chronic bronchial diseases (60ml)

How to use

Bisolvon Kids oral use.

Dosage

Adults and children over 12 years: 10 ml (8 mg) 3 times daily.

Children 6 -12 years old: 5 ml (4 mg) 3 times daily.

Children 2 - 6 years old: 2.5 ml (2mg) 3 times daily.

Children under 2 years old: 1.25 ml (1 mg) 3 times daily.

At the beginning of treatment, it is necessary to increase the total daily dose to 48 mg (60 ml or 20 ml 3 times daily) in adults and children over 12 years old.

The dose cup includes in the product with the appropriate dose line.

Sires do not contain sugar, therefore suitable for patients with diabetes and young children.

Bisolvon Siro treatment time does not exceed 8 - 10 days without consulting the doctor.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Based on the overdose reports by accident and/or using the wrong drug, the observation symptoms are suitable for Bisolvon's known side effects at the recommended dose and may need symptom treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Bisolvon 4mg you may experience unwanted effects (ADR).

Uncommon, 1/1000

Gastrointestinal disorders: Nausea, vomiting, diarrhea and abdominal pain.

Rare, ADR

  • The immune system disorder: Hypersensitivity.
  • Immune system disorders: Anaphylaxis, anaphylaxis.

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    • Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Bisolvon 4mg drug is contraindicated in the following cases:

  • Patients who already know hypersensitivity to bromhexin or other ingredients of the drug.
  • Patients with rare genetic diseases that may not be compatible with any excipients of the drug.

    • Be cautious when using

    There are very few serious skin damage reports such as Stevens -Johnson syndrome and poisoned epidermal epidermal necrosis (TEXIC EPIDERMAL NECROLYSIS -TEN) Temporarily related to the use of phlegm as bromhexin. Most cases are explained by the disease that the patient is suffering from and/or medication. Moreover, in the early stages of Stevens-Johnson or Ten's syndrome, the patient first has a million-like influenza-like influenza like fever, human aches, rhinitis, cough and sore throat. Due to being confused by these non -specific influenza varieties, one can start treating symptoms of cough and colds. Therefore, if a few new lesions appear on the skin or mucosa, you should see a doctor immediately and stop treatment with bromhexin.

    Bisolvon 4 mg/5 ml contains 17,142 g of liquid sorbitol for each daily daily recommended dose (equivalent to 34,284g in the case of double doses in adults at the beginning of treatment).

    Do not use drugs in patients with rare genetic diseases with fructose. The drug may have a mild laxative effect.

    Be careful when using Bisolvon Siro simultaneously and cough inhibitors to avoid accumulation of secretions due to cough decline and this combination should only be used after benefits - risks.

    Use cautiously in patients with stomach ulcers.

    Use cautiously in asthma patients because bromhexin can cause bronchospasm in some sensitive people. Must be very cautious when using bisolvon in patients with severe renal impairment or liver failure, in patients with severe renal impairment, accumulating the metabolites of bromhexin formed in the liver may occur. Use cautiously in patients who are elderly, weak or too weak without sputum ability.

    The ability to drive and operate machinery

    has not studied the effects of bisolvon on driving and operating machinery

    Pregnancy

    Data using bromhexin for pregnant women is limited.

    Animal studies do not show direct or indirect harmful effects related to reproductive toxicity.

    Be cautious by avoiding using bisolvon during pregnancy.

    Breastfeeding period

    It is unclear whether bromhexin/metabolites will be secreted into the mother's milk.

    Data available for pharmacological/toxicity in animals shows the excretion of bromhexin/metabolites into the mother's milk. Can not rule out the risk for breastfeeding. Do not use bisolvon during breastfeeding.

    Drug interaction

    has not seen a report on adverse interactions with other drugs in terms of clinical.

    Be careful when using Bisolvon Siro simultaneously and cough inhibitors to avoid accumulation of secretions due to cough decline and this combination should only be used after benefits - risks.

    Avoid using bromhexin with drugs that reduce secretion like atropine -style drugs.

    Using bromhexin combination with antibiotics increases antibiotic into the lung and bronchial tissue, so the drug is used in combination with antibiotics in the treatment of respiratory tract bacteria.

    Storage

    Store in a cool dry place and avoid light, not more than 30 ° C.

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