Siro Coje Ho TW3 reduces cough symptoms (75ml)

Dosage form Bottle x 75ml
Specifications Dextromethorphan, chlorpheniramin maleat, glycerin, ammonium chloride
Ingredient Dry cough, allergic disease, colds, runny nose, watery eyes, rashes, stuffy nose

Ingredient

Composition information	Content
Dextromethorphan	75mg
Chlorpheniramin Maleat	19.95mg
Glycerin	750mg
Ammonium chloride	750mg

Uses

Indications

Coje cough drugs are indicated in cases of reducing cough symptoms in cases such as coughs due to colds, flu, dry cough, allergic cough, runny nose, nasal congestion, watery and itching. Cough due to sucking lots of cigarettes, inhaling irritants.

Pharmacokic

dextromethorphan hydrobromid is a cough reduction drug that works on the cough center in the brain. Dextromethorphan is used for temporary cough due to mild stimulation in the bronchial and throat as usual cold or inhaled stimulants. Dextromethorphan is most effective in the treatment of chronic cough, without sputum. The drug is often used in combination with many other substances in the treatment of upper respiratory symptoms.

Clorpheniramin Maleat is an antihistamine with very little sedative effects. The antihistamine effect of chlorpheniramine through the block of the H1 receptor of the acting cells.

Glyceryl Guaiacolat (Guaifenesin) is a phlegm, it stimulates or facilitates the removal of the respiratory secretions through increased mass and makes the mucus less sticky than sputum.

Ammonium chloride causes mild irritation on the bronchial mucosa to increase the secretion of the respiratory tract, reduce dryness and pain of the respiratory tract.

pharmacokinetic

dextromethorphan is quickly absorbed through the digestive tract and works within 15 - 30 minutes after drinking, lasting about 6-8 hours (12 hours with slow liberation form). The drug is metabolized in the liver and excreted through the urine in the form of constant and Demethyl metabolites, among them dextromethorphan also has a slight cough reduction effect.

Clorpheniramin Maleat absorbs well when drinking and appears in plasma for 30-60 minutes. Plasma peak concentration is about 2.5-6 hours after drinking. Low bioavailability, reaching 25-50%. About 70% of the drug during the circulation associated with the protein. The distribution volume is about 3.5 liters/kg (adults) and 7-10 liters/kg (children). Chlorpheniramin Maleat metabolizes fast and high. The drug is excreted mainly in urine in the form of constant or metabolic, the excretion depends on the pH and the urine flow. Only a small amount is seen in the feces. The sale time is 12-15 hours and in patients with chronic renal failure. Glyceryl Guaiacolat absorbs easy by oral, 1 hour waste sale time.

glyceryl guaiacolate metabolized through the liver and excreted mainly through the kidneys

Ammonium chloride quickly absorbed through the gastrointestinal tract when used by oral. Ammonium chloride metabolizes in the liver into urea and hydrochloride acid; Elimination through the kidneys.

Before taking Siro Coje Ho TW3 reduces cough symptoms (75ml)

How to use

Take oral use.

Dosage

Take oral 2 times/day or as instructed by a physician.

Children from 2 - 6 years old: 5ml (1 teaspoon).

Children from 7-12 years: 10ml (2 teaspoons).

Adults and children over 12 years: 15ml (3 teaspoons).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms: nausea, vomiting, drowsiness, blurred vision, eyeball shaking, urination, numbness, hallucinations, loss of air conditioning, respiratory failure, convulsions.

Treatment: Support, use Naloxon 2 mg intravenously, for reminders if the total dose of 10 mg is needed.

chlorpheniramin maleat

Symptoms: Sedative, naughty stimulation often central nervous system, mental disorder, epilepsy, apnea, convulsions, anti -secretion effect acetylcholin, hypertonic and cardiovascular disorder reaction, arrhythmia.

Treatment: gastrointestinal or vomiting with ipecacuanha syrup, then activate carbon and bleach to limit absorption, in case of antihypertensive and arrhythmia, should be actively treated. Diazepam or intravenous phenytoin may be useful and treat convulsions. Can blood transfusion in heavy cases.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using COJE HO medicine, you may experience unwanted effects (ADR).

dextromethorphan

Common, ADR> 1/100

Body: Fatigue, dizziness.

Circulation: tachycardia.

digestive: nausea. skin: flushed.

Uncommon, 1/1000

Skin: urticaria

Rare, ADR

Skin: Ban Ban.

Clorpheniramin Maleat

Common, ADR> 1/100

Central nervous system: Sleeping, sedation.

digest: dry mouth.

Rare, ADR

Body: Dizziness.

digestive: nausea.

The sedative effect changes from jagged to deep sleep may occur but will decrease after a few days. Other side effects include digestive disorders and mild neurological disorders.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Coje cough drugs in the following cases:

Sensitive to any ingredients of the drug.

Clorpheniramin Maleat: Patients with acute asthma attacks, people with symptoms of prostate hypertrophy, narrow-angle glaucom, bladder neck obstruction, stomach ulcer, pyloric garges, nursing mothers, newborn babies and malnutrition, users of Mao inhibitors within 14 days to the time of treatment with chlorpheniramin.

dextromethorphan: The person who is being treated inhibitors

Caution when using

Dextromethorphan: Patients with coughs have too many sputum and chronic coughs in smokers, asthma or gas overflow; People at risk or respiratory decline; Using dextromethorphan is related to histamine release and should be cautious with children with allergies.

Clorpheniramin Maleat: The sedative effect of chlorpheniramin increases when drinking alcohol and using simultaneously with other sedatives, people with glaucoma; Elderly (> 60 years old) because these people often increase sensitivity to anti -secretion effect acetylcholin.

The ability to drive and operate machinery

affect the ability to drive and operate machinery due to drugs containing chlorpheniramin ingredients that cause chicken, dizziness, dizziness, blurred vision.

Pregnancy

Because Glyceryl Guaiacolat through the placenta should not be used for pregnant women.

Chlorpheniramin is only used for pregnant women when necessary. Currently, the effect of dextromethorphan for pregnant women is unknown, so they only use when necessary and have a doctor's instructions.

Breastfeeding period

only used when necessary and must follow the instructions of the physician. Clorpheniramin can be secreted through breast milk and inhibit milk. Because antihistamine drugs can cause serious reactions to breastfeeding, should consider or not breastfeed or do not take the drug, depending on the level of the drug's necessary to the mother.

Drug interaction

for chlorpheniramin maleat

Monoamine oxidase inhibitors (Mao) prolonged and increased the anti -secretion effect of acetylcholine of antihistamine drugs.

ethanol or sedative drugs can increase the inhibition effect of TKTW of chlorpheniramin.

chlorpheniramine inhibits phenytoin metabolism and can lead to phenytoin poisoning.

For dextromethorphan

Avoid use with Mao inhibitors.

Simultaneously used with central neurological inhibitors can enhance the central neurological inhibitor of these drugs or of dextromethorphan.

Cytochrom P4502D6 quinidine can metabolize the metabolism of dextromethorphan in the liver, increasing the concentration of this substance in serum and increasing the undesirable uses of dextromethorphan.

Storage

in a dry place, avoid light, at room temperature.

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