Siro Daleston-D TW3 against allergies, anti-inflammatory (75ml)

Dosage form Bottle
Specifications Betamethasone, dexchlorpheniramine maleatamine
Ingredient Allergic rhinitis, urticaria, upper respiratory tract

Ingredient

Thành phần cho 5ml

Composition information	Content
Betamethasone	0.25mg
Dexchlorpheniramine maleaty	2mg

Uses

indications

Daleston D drug is indicated in the following cases:

Anti -allergy when needing corticosteroid therapy. Strong, accompanied by negligible salt water metabolism. 0.75 mg of betamethasone has an anti -inflammatory effect equivalent to about 5 mg of prednisolon.

betamethasone has anti -inflammatory, anti -rheumatism, anti -allergic, and high doses that inhibit immunosuppressive effects.

Oral, injected, injected, inhaled or applied drugs to treat many diseases that need to be indicated to use corticosteroids. Due to the little effect on the metabolism of salt water, Betamethasone is very suitable in cases where the pathology that holds water is disadvantage.

dexclorpheniramine maleat is a derivative antihistamine of propylamine. Dexclorpheniramine Maleat inhibits competition with pharmacological effects of histamine (i.e. antagonistic substance with H1 receptor histamine).

pharmacokinetics

betamethasone is easily absorbed through the gastrointestinal tract. The drug is also easy to be absorbed when used on the spot. When applied, especially if the skin is torn or when the skin is torn or when the rectal indentation, there may be a amount of betamethasone that is absorbed enough for the whole body effect.

Water -soluble betamethasone forms used intravenously to quickly respond to the forms of intramuscular lipids will give a longer effect.

betamethason quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts.

During the circulation, Betamethason is linked mainly to globulin, with little albumin. Betamethasone ratio is linked to blood protein about 60% lower than hydrocortison.

betamethason is a lasting corticosteroid for half a life of about 36 - 54 hours. Because Betamethason has slow metabolic speed, low protein and half -life rates, the effect is stronger and the effect lasts longer than natural corticosteroids.

dexclorpheniramin maleat is about 25-50% due to significant metabolized when the first time. The drug reaches the maximum concentration in the blood after 2-6 hours. The maximum effect is achieved after taking 6 hours. The impact time is 4 - 8 hours. The ratio attached to plasma protein is 72%.

The drug is metabolized mainly in the liver and produces methyl -original metabolites, which is not active. The drug is mainly eliminated through the kidneys and depending on the urine pH, 34% dexclorpheniramine is excreted in a constant form and 22% in the form of methyl -original metabolites. Selling time from 14 - 25 hours.

Before taking Siro Daleston-D TW3 against allergies, anti-inflammatory (75ml)

How to use

Daleston-D drugs in the form of oral orally.

Dosage

Dosage to treat chronic bronchial asthma, allergic bronchitis, allergic rhinitis: drink 2-3 times/day.

Children from 2 - 6 years old: 2.5 ml/time, not exceeding 7.5 ml daily. Neuritis, contact dermatitis, urticaria: drink 2-3 times/day.

Children from 2 - 6 years old: 2.5 ml/time, not exceeding 7.5 ml per day. The weight of the disease and the patient's response rather than relying only entirely on the dose prescribed by age, body weight or body area.

Digestive symptoms may decrease slightly, if daleston d medicine with food or milk.

Dosage should be based on the response and tolerance of each patient. If after the desired response, it is necessary to reduce the dosage in small steps until the lowest level can be maintained to be fully clinically met. Need to stop the drug as soon as possible.

When the treatment lasts for prolonged treatment, it is necessary to stop betamethasone gradually gradually.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

betomethason: Systemic effects due to overdose of corticosteroids include: Sodium holding and water retention, increased appetite, mobilizing calcium and phosphorus accompanied by osteoporosis, loss of nitrogen, hyperglycemia, reducing tissue regeneration, increasing sensions with bacterial infections, adrenal impairment, increased mental and mental disorders, muscle disorders.

dexclorpheniramin maleat: Signs of overdose include depression and central nervous stimulation (especially in children), death, dizziness, tinnitus, loss of air conditioning, blurring vision, hypotension.

How to handle:

In case of an overdose, the electrolyte must be monitored with serum and urine. Pay special attention to sodium and potassium balance. In the case of chronic poisoning, stop the drug slowly. Treatment of electrolyte imbalance if needed.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Daleston-D drug, you may experience unwanted effects (ADR).

Common, ADR> 1/100

The immune system: rash, light sensitivity.

Nervous system: sedation, suspense, disappointment, excitement, headache, dizziness, tinnitus, vestibular disorders, anxiety, tremor, abnormal sensation, neuritis.

Digestive system: dry mouth, heartburn, bloating, anorexia, constipation.

Urinary urinary: frequent urination, difficulty urinating, urinary retention, kidney disease due to steroids.

circulatory system: lower blood pressure, tachycardia, spasm.

Respiratory system: Dry nose, stuffy nose.

Blood and lymphatic system: Hemorrhagic anemia, leukemia.

Liver: Liver dysfunction (increase AST (GOT), Alt increases (GPT), increase AI - P).

Endocrine: Menstrual disorders, diabetes.

musculoskeletal system: muscle pain, joint pain.

Metabolism: Fatty liver.

Body fluid and electrolyte: edema, alkaline infection, potassium lower.

Eye: retinal disorders.

Skin and tissue subcutaneous: Hair loss, acne, melasma under the skin, rash itching, abnormal sweat, blushing, thin skin.

Common disorders: fever, fatigue, chest pain.

rarely, 1/1000

Nervous system: Insomnia, drowsiness, severe head.

Infection: Infection and worsening infectious diseases.

Kidney: acute adrenal failure.

Stomach: Stomach ulcer.

Mental: depression, convulsions.

Digestive system: abdominal pain, nausea, vomiting, diarrhea.

blood vessels: hypertension.

General disorder: weight gain.

rare, ADR

cardiovascular system: thrombosis.

Blood and lymphatic system: Anemia, granulocytes, platelets.

Not determined frequency

Kidney: secondary adrenal failure.

endocrine and metabolism: diabetes.

Stomach: Pancreatitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using Daleston D, you need to read the instructions carefully and refer to the information below.

contraindicated

Daleston-D drug contraindicated in the following cases:

sensitive to betamethasone or other corticosteroids and dexclorpheniramin.

Patients with diabetes, mental illness, severe infections, viral infections, body fungal infections.

Children under 2 years old.

Patients with symptoms of prostate hypertrophy, urination.

Patients with glaucoma.

Be cautious when using

The lowest can be used with corticosteroids to control the treatment that is treating, when reducing the dose, it must gradually decrease by step by step.

Be cautious in case of congestive heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucoma, thyroid defect, liver failure, osteoporosis, stomach ulcers, mental disorders and kidney failure.

Potential tuberculosis must be closely monitored and must be used to prevent tuberculosis, if corticosteroids must be extended.

The risk of chickenpox and maybe both severe zoster infection, increased in patients who are unable to respond to immune response when using systemic corticosteroids and patients must avoid exposure to these diseases.

Do not use living vaccines in patients who are using high -dose systemic corticosteroids and at least 3 months later.

During long -term corticosteroid therapy, patients must be monitored regularly. May need to reduce the amount of sodium and supplement calcium and potassium.

Older patients are more likely to have posture hypotension, dizziness, drowsiness, chronic constipation (due to the risk of intestinal obstruction); prostate swelling; Patients with liver failure, severe renal failure due to the risk of drug accumulation; Avoid drinking alcohol and alcohols during treatment.

Inhibits the development of babies and children may occur, so please look closely and if you find abnormalities, stop using Daleston d.

Ingredients:

White sugar: can be harmful to teeth.

Sorbitol: This drug contains 250 mg of sorbitol in each 2.5 ml of the 2.5 ml. Sorbitol can cause discomfort to the gastrointestinal tract and have a light laxative effect.

sodium benzoate: This drug contains 5 mg of sodium benzoate in a 2.5 ml -dose bait. Sodium benzoate may increase the risk of jaundice (jaundice and eye) in infants (up to 4 weeks of age).

ethanol: This drug contains a small amount of ethanol, less than 100 mg each dose 2.5 ml.

Quinolin color, amaranth: can cause allergic reactions.

The ability to drive and operate machinery

Average effect, need to be cautious when taking the drug for the driver and operating machinery due to Daleston D medicine that is likely to cause sleepiness.

Pregnancy

Use corticosteroids during pregnancy or in people who are likely to consider the benefits and risks of the mother and embryo or fetus. There was a weight loss in newborns when the mother was treated with long -term corticosteroids.

The period of breastfeeding

Exporting drugs into breast milk and harmful to children because of the drug inhibitors and causes other unwanted effects, such as reducing adrenal gland function. Benefits for mothers must be considered with the ability to harm children or stop breastfeeding when taking this drug.

Interactive drug

Do not use Daleston D medicine for patients who are taking Monoamine Oxidase inhibitors.

paracetamol: corticosteroids induce liver enzymes, which can increase to form a metabolic of toxic paracetamol to the liver. Therefore, when corticosteroid is used with high or prolonged paracetamol paracetamol, the risk of liver poisoning will increase.

Triple -round antidepressants: These drugs do not reduce and may increase mental disorders caused by corticosteroids; Do not use these antidepressants to treat the above unwanted effects.

Oral or insulin anti -diabetes: Betamethasone may increase blood glucose levels, so it is necessary to adjust the dose of one or both drugs when used simultaneously; It may also be necessary to adjust the dose of hypoglycemic drugs after stopping corticosteroid therapy.

glycosid digitalis: simultaneously used with betamethasone may increase the possibility of arrhythmia or toxicity of digitalis and hypotension.

Phenobarbital, Phenytoin, Rifampicin or Ephedrin may increase corticosteroid metabolism and reduce their treatment effects.

anti -inflammatory steroids: When used in combination with corticosteroids, it can lead to increased occurrence or increased severity of gastrointestinal ulcers. Corticosteroid increases bloodlate concentration in the blood. Must be cautious when used in combination with aspirin with corticoids in the case of reducing blood prothrombin.

Alcohol and sedatives that cause sleep can increase the inhibition effect of TKTW of dexclorpheniramin maleat.

Corticosteroids with corticosteroids with anticoagulants can increase or decrease against anticoagulants, so it may be necessary to adjust the dose.

dexclorpheniramin maleat inhibits the effects of oral anticoagulants.

Storage

In a cool dry place, the temperature does not exceed 30 ° C.

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