Siro Daleston-D TW3 anti-allergic, anti-inflammatory (30ml)

Dosage form Bottle
Specifications Betamethasone, dexchlorpheniramine maleatamine
Ingredient Allergic rhinitis, urticaria, upper respiratory tract

Ingredient

Composition information	Content
Betamethasone	1.5mg
Dexchlorpheniramine maleaty	12mg

Uses

indications

Daleston-D 30ml drug indicated in the following cases:

Anti -allergy when needing corticosteroid therapy. Strong, accompanied by negligible salt water metabolism. 0.75 mg of betamethasone has an anti -inflammatory effect equivalent to about 5 mg of prednisolon.

betamethasone has anti -inflammatory, anti -rheumatic, anti -allergic and high doses effect. Drugs used oral, injection, injecting, inhalation or application to treat many diseases need to be indicated to use corticosteroids. Due to the little effect on the metabolism of salt water, Betamethasone is very suitable in cases where the pathology that holds water is disadvantage.

dexclorpheniramine maleat is a derivative antihistamine of propylamine. Dexclorpheniramine Maleat inhibits competition with pharmacological effects of histamine (i.e. antagonistic substance with H1 receptor histamine).

pharmacokinetics

absorption:

Betamethason is easily absorbed through the gastrointestinal tract. The drug is also easy to be absorbed when used on the spot. When applied, especially if the skin is torn or when the skin is torn or when the rectal indentation, there may be a amount of betamethasone that is absorbed enough for the whole body effect.

Water -soluble betamethasone forms are used intravenously for quick response, the form of intramuscular lipids will last longer.

dexclorpheniramin maleat reaches the maximum concentration in the blood after 2-6 hours. The maximum effect is achieved after taking 6 hours. The impact time is 4 - 8 hours. Birth is about 25 - 50 % due to significant metabolized when passing the liver for the first time.

Distribution:

betamethason quickly distributed into all tissues in the body. The drug through the placenta and can be exported to breast milk in small amounts. During the circulation, Betamethason is linked mainly with globulin, with little albumin.

Betamethason ratio is linked to plasma proteins about 60% lower than hydrocortison. Betamethason is a lasting corticoid for half a life of about 36 - 54 hours.

Dexclorpheniramin Maleat has a ratio of plasma protein at 72%.

Metabolism:

betamethason is metabolized mainly in the liver.

Dexclorpheniramin Maleat is metabolized mainly in the liver and creates metabolites that are methyl root, this substance is not active.

Era:

betamethason excreted the kidneys mainly with the metabolic rate of less than 5%. Because the drug has a slow metabolic rate, the rate of links with low protein and half -life is long, it is more effective and the effect lasts longer than natural corticosteroids.

Dexclorpheniramin Maleat is mainly eliminated through the kidneys and depending on the urine pH, 34% dexclor-pheniramine is excreted in a constant form and 22% in the form of methyl-original metabolites. Selling time from 14 - 25 hours.

Before taking Siro Daleston-D TW3 anti-allergic, anti-inflammatory (30ml)

How to use

Daleston d Siro should be taken with milk or during meals.

Dosage

Dosage for treatment of chronic bronchial asthma, allergic bronchitis, allergic rhinitis: drink 2-3 times/day.

Children from 2 - 6 years old: 2.5 ml/time, not exceeding 7.5 ml per day. Sutta, contact dermatitis, urticaria: drink 2-3 times/day.

Children from 2 - 6 years old: 2.5 ml/time, not exceeding 7.5 ml daily. The weight of the disease and the patient's response rather than relying only entirely on the dose prescribed by age, body weight or body area.

Digestive symptoms may decrease slightly, if taking medicine with food or milk.

Dosage should be based on the response and tolerance of each patient. If after the desired response, it is necessary to reduce the dosage in small steps until the lowest level can be maintained to be fully clinically met. Need to stop the drug as soon as possible.

When the treatment lasts for prolonged treatment, it is necessary to stop betamethasone gradually gradually.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:

Betomethason: Keeping sodium and water retention, increased appetite, mobilizing calcium and phosphorus accompanied by osteoporosis, loss of nitrogen, hyperglycemia, reducing tissue regeneration, increasing perception of infections, adrenal insufficiency, increased renal shell activity, mental disorders and nerves, muscle weakness.

dexdorpheniramin maleat: depression and stimulation of the central nervous system (especially in children), death, dizziness, tinnitus, loss of air conditioning, blurring, hypotension.

How to handle:

In case of an overdose, the electrolyte must be monitored with serum and urine. Pay special attention to sodium and potassium balance. In the case of chronic poisoning, stop the drug slowly. Treatment of electrolyte imbalance if needed.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Daleston-D 30ml, you may experience unwanted effects (ADR).

Common, ADR> 1/100

The immune system: rash, light sensitivity.

Nervous system: sedation, suspense, disappointment, excitement, headache, dizziness, tinnitus, vestibular disorders, anxiety, tremor, abnormal sensation, neuritis.

Digestive system: dry mouth, heartburn, bloating, anorexia, constipation.

Urinary urinary: frequent urination, difficulty urinating, urinary retention, kidney disease due to steroids.

circulatory system: lower blood pressure, tachycardia, spasm.

Respiratory system: Dry nose, stuffy nose.

Blood and lymphatic system: Hemorrhagic anemia, leukemia.

Liver: Liver dysfunction (increase AST (GOT), Alt increases (GPT), increase AI - P).

Endocrine: Menstrual disorders, diabetes.

musculoskeletal system: muscle pain, joint pain.

Metabolism: Fatty liver.

Body fluid and electrolyte: edema, testing, lower potassium.

Eye: retinal disorders.

Skin and tissue subcutaneous: Hair loss, acne, melasma under the skin, rash itching, abnormal sweat, blushing, thin skin.

Common disorders: fever, fatigue, chest pain.

rarely, 1/1000

Nervous system: Insomnia, drowsiness, severe head.

Infection: Infection and worsening infectious diseases.

Kidney: acute adrenal failure.

Stomach: Stomach ulcer.

Mental: depression, convulsions.

Digestive system: abdominal pain, nausea, vomiting, diarrhea.

blood vessels: hypertension.

General disorder: weight gain.

rare, ADR

cardiovascular system: thrombosis.

Blood and lymphatic system: Anemia, granulocytes, platelets.

Not determined frequency

Kidney: secondary adrenal failure.

endocrine and metabolism: diabetes.

Stomach: Pancreatitis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Daleston-D 30ml drug is contraindicated in the following cases:

sensitive to betamethasone or other corticosteroids and dexclorpheniramin.

Patients with diabetes, mental illness, severe infections, viral infections, body fungal infections.

Children under 2 years old.

Symptoms of prostate hypertrophy, urination.

Patients with glaucoma.

Be cautious when using

The lowest can be used with corticosteroids to control the treatment that is treating, when reducing the dose, it must gradually decrease by step by step.

Be cautious in case of congestive heart failure, new myocardial infarction, hypertension, diabetes, epilepsy, glaucoma, thyroid defect, liver failure, osteoporosis, stomach ulcers, mental disorders and kidney failure.

Potential tuberculosis must be closely monitored and must be used to prevent tuberculosis, if corticosteroids must be extended.

The risk of chickenpox and maybe both severe zoster infection, increased in patients who are unable to respond to immune response when using systemic corticosteroids and patients must avoid exposure to these diseases.

Do not use living vaccines in patients who are using high -dose systemic corticosteroids and at least 3 months later.

During long -term corticosteroid therapy, patients must be monitored regularly. May need to reduce sodium and supplement calcium and potassium.

Older patients are more likely to have posture hypotension, dizziness, drowsiness, chronic constipation (due to the risk of intestinal paralysis), prostate swelling, patients with liver failure, severe kidney failure due to the risk of drug accumulation. Avoid drinking alcohol and alcohols during treatment.

Inhibits the development of babies and children may occur, so be careful and if abnormal detection, stop using the drug.

Ingredients:

White sugar: can be harmful to teeth.

Sorbitol: This drug contains 250 mg of sorbitol in each dose of 2.5 ml. Sorbitol can cause discomfort to the gastrointestinal tract and have a light laxative effect.

Sodium benzoate: This drug contains 5 mg of sodium benzoate in each dose of 2.5 ml. Sodium benzoate may increase the risk of jaundice (jaundice and eye) in infants (up to 4 weeks of age).

ethanol: This drug contains a small amount of ethanol, less than 100 mg each dose 2.5 ml.

Quinolin color, amaranth: can cause allergic reactions.

The ability to drive and operate machinery

need to be cautious when taking drugs for drivers and operating machinery due to drugs that can cause drowsiness.

Pregnancy

Use corticosteroids during pregnancy or in people who are likely to consider the benefits and risks of the mother and embryo or fetus. There was a weight loss in newborns when the mother was treated with long -term corticosteroids.

The period of breastfeeding

Exporting drugs into breast milk and harmful to children because of the drug inhibitors and causes other unwanted effects, such as reducing adrenal gland function. Benefits for mothers must be considered with the ability to harm children or stop breastfeeding when taking this drug.

Interactive drug

Do not use drugs for patients who are taking Monoamine Oxidase inhibitors.

corticosteroids induce liver enzymes, which can increase to form a metabolic substance of toxic paracetamol to the liver. Therefore, when corticosteroid is used with high or prolonged paracetamol paracetamol, the risk of liver poisoning will increase.

Triple antidepressants: These drugs do not reduce and may increase the mental disorders caused by corticosteroids, do not use these antidepressants to treat the above -mentioned unwanted effects.

Oral or insulin diabetes treatment: Betamethasone may increase blood glucose levels, so it is necessary to adjust the dose of one or both medications when used simultaneously. It may also be necessary to adjust the dose of diabetes treatment after stopping corticosteroid therapy.

Betamethasone may increase the possibility of arrhythmia or toxicity of glycosid digitalis and hypotension.

Phenobarbital, Phenytoin, Rifampicin or Ephedrin may increase corticosteroid metabolism and reduce their treatment effects.

anti -inflammatory steroids when used in combination with corticosteroids can lead to increased occurrence or severity of the gastrointestinal ulcer. Corticosteroid increases bloodlate concentration in the blood. Must be cautious when used in combination with aspirin with corticoids in the case of reducing blood prothrombin.

Alcohol and sedatives that cause sleep can increase the inhibition effect of TKTW of dexclorpheniramin maleat.

Corticosteroids with corticosteroids with anticoagulants can increase or decrease against anticoagulants, so it may be necessary to adjust the dose.

dexclorpheniramin maleat inhibits the effects of oral anticoagulants.

Storage

In a cool dry place, the temperature does not exceed 30 ° C.

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