Siro Lorastad SP. Stella reduces chronic rhinitis and urticaria (60ml)

Dosage form Syrup
Specifications Bottle x 60ml
Ingredient Loratadine
Indication Rhinitis, urticaria

Ingredient

Thành phần cho 5ml

Composition information	Content
Loratadine	5mg

Uses

indications

Lorastad spaces are indicated in the following cases: reducing symptoms of allergies including rhinitis and chronic urticaria.

Pharmacokic

Loratadin is a 3 -round antihistamine that has a long -lasting effect with selective antagonistic activity on the H1 receptor on the peripheral.

Pharmacokinetics

absorption

Loratadin is quickly absorbed through the gastrointestinal tract after drinking, the peak concentration of plasma is reached for about 1 hour.

Increased bioavailability and time to reach peak plasma concentrations slowly when shared with food.

Distribution

About 98% of Loratadine binds to plasma proteins; Desloratadine binds less. Loratadin and metabolites are detected in breast milk, but not through the bloody barrier in significant amounts.

Metabolism

Loratadin is metabolized. The main metabolites are desloratadine with effective antihistamine activity.

Elimination

The average selling time was reported by loratadin and desloratadin, respectively 8.4 and 28 hours. Most of the drug dose is excreted in urine and feces in the same amount, mainly in the form of metabolites.

Loratadin's distribution does not see significant changes in patients with severe renal impairment and hemorrhage is not a measure of effectiveness of loratadine and diameters of desloratadin from the body.

Before taking Siro Lorastad SP. Stella reduces chronic rhinitis and urticaria (60ml)

How to use

Lorastad sp is oral medication.

Dosage

Adults and children over 12 years old

10 ml x 1 time/day.

Children from 2 - 12 years old

2 - 5 years: 5 ml/day (= 1 tablespoon/day).

6 - 12 years: 10 ml/day (= 2 tablespoons/day).

People with severe liver or kidney failure (Creatinine clearance

Adults and children aged 6 and older: The starting dose of 10 ml/time, every 2 days.

Children from 2 years old to under 6 years old: dose 5 ml/time, every 2 days.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Adults: Sleep, tachycardia and headache (use 40 - 180 mg of Loratadin).

Children: expression of foreign tower and suspense (using more than 10 mg).

Treatment

Treatment of ordinary loratadin overdose includes symptomatic treatment and supportive treatment, which is done immediately and maintained until necessary.

In case of Loratadin's overdose, the stomach should be empty by using ipeca syrup. Taking activated carbon after vomiting can effectively prevent Loratadin's absorption. If vomiting is ineffective or contraindicated (such as with a coma, convulsions), it is possible to conduct a stomach rinse with 0.9% NaCl solution if there is an internal intubation to prevent inhalation of the lungs in the stomach. Salt water has the effect of quickly diluting the substances contained in the intestine.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Lorastad SP, you may experience unwanted effects (ADR).

The severe ventricular arrhythmia occurred when treated with some 2nd generation H1 histamine anti -receptors. That did not appear when treated with loratadine. When using loratadin at a dose greater than 10 mg daily, the following unwanted effects may occur.

Common, ADR> 1/100

Neurological: headache.

digestive: dry mouth.

Uncommon, 1/1000

Neurological: Dizziness.

Respiratory: dry nose and sneezing.

Other: conjunctivitis.

Rare, 1/10,000

Neurology: depression.

Cardiovascular: Heart beat fast, tachycardia on ventricular, nervous. digestive: nausea.

Metabolism: abnormal liver function, irregular menstruation.

Other: Ban, urticaria and anaphylaxis.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Lorastad sp is contraindicated in the following cases:

Patients with hypersensitivity or allergies to any ingredients of the drug.

Children under 2 years old.

Caution when using

liver failure.

When using Loratadin, there is a risk of dry mouth, especially in the elderly, and increasing the risk of tooth decay. Therefore, clean oral hygiene when using loratadin.

The ability to drive and operate machinery

in clinical trials shows that there is no decline in driving ability in patients using loratadin. However, patients must be notified that a few people have been drowsy, which can affect the ability to drive or operate machinery.

Pregnancy

Safety when using loratadin preparations during pregnancy has not been determined, therefore, only medication if the treatment benefits are higher than the risk of fetus in the lowest possible and shortest doses.

Lactation period

due to loratadin and metabolites are also active as desloratadin excreted through breast milk and because of the dangers of antihistamine drugs that increase in children, especially newborns and premature babies, should decide to stop breastfeeding or stop taking drugs.

Drug interaction

simultaneous treatment of loratadine and cimetidine leads to an increase in loratadine concentration in plasma 60%, due to cimetidine inhibiting metabolic of loratadin. This has no clinical manifestations.

Simultaneous treatment of Loratadine and Ketoconazole leads to an increase in loratadine levels in plasma 3 times, due to CYP3A4 inhibitors. That has no clinical manifestations because Loratadin has a broad treatment index.

Concomitance of Loratadin and erythromycin leads to increased plasma Loratadin levels. AUC (area under the curve of the concentration over time) of Loratadin, an average increase of 40% and the AUC of Descarboethoxyloratadin increases an average of 46% compared to the single Loratadin treatment. On the center of the center, there is no change in the QTC range. Clinically, there is no manifestation of loratadin's safety change, and there is no notice of sedative effects or fainting phenomenon when treating these two drugs simultaneously.

Cavalry statue

Because there is no studies on the cavalry of the drug, does not mix this drug with other drugs.

Storage

In closed packaging, avoiding light. The temperature does not exceed 30 ° C.

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